inhibitory interaction between viral and cellular proteins underlies the resistance of tomato to nonadapted tobamoviruses
Any individual virus can infect only a limited range of hosts, and most plant species are "nonhosts" to a given virus; i.e., all members of the species are insusceptible to the virus. In nonhost plants, the factors that control virus resistance are not genetically tractable, and how the ho...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2009-05, Vol.106 (21), p.8778-8783 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8783 |
|---|---|
| container_issue | 21 |
| container_start_page | 8778 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 106 |
| creator | Ishibashi, Kazuhiro Naito, Satoshi Meshi, Tetsuo Ishikawa, Masayuki |
| description | Any individual virus can infect only a limited range of hosts, and most plant species are "nonhosts" to a given virus; i.e., all members of the species are insusceptible to the virus. In nonhost plants, the factors that control virus resistance are not genetically tractable, and how the host range of a virus is determined remains poorly understood. Tomato (Solanum lycopersicum) is a nonhost species for Tobacco mild green mosaic virus (TMGMV) and Pepper mild mottle virus (PMMoV), members of the genus TOBAMOVIRUS: Previously, we identified Tm-1, a resistance gene of tomato to another tobamovirus, Tomato mosaic virus (ToMV), and found that Tm-1 binds to ToMV replication proteins to inhibit RNA replication. Tm-1 is derived from a wild tomato species, S. habrochaites, and ToMV-susceptible tomato cultivars have the allelic gene tm-1. The tm-1 protein can neither bind to ToMV replication proteins nor inhibit ToMV multiplication. Here, we show that transgenic tobacco plants expressing tm-1 exhibit resistance to TMGMV and PMMoV. The tm-1 protein bound to the replication proteins of TMGMV and PMMoV and inhibited their RNA replication in vitro. In one of the tm-1-expressing tobacco plants, a tm-1-insensitive TMGMV mutant emerged. In tomato protoplasts, this mutant TMGMV multiplied as efficiently as ToMV. However, in tomato plants, the mutant TMGMV multiplied with lower efficiency compared to ToMV and caused systemic necrosis. These results suggest that an inhibitory interaction between the replication proteins and tm-1 underlies a multilayered resistance mechanism to TMGMV in tomato. |
| doi_str_mv | 10.1073/pnas.0809105106 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_19423673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40482758</jstor_id><sourcerecordid>40482758</sourcerecordid><originalsourceid>FETCH-LOGICAL-c618t-74c817c2e89c0622e4d219cc0719f230af1d49a52696727be50af068ca7e08713</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhzAmwekBcth07ju1ckFDFl1SJA_RseZ1J16vEDrZT2H9fL7vqAgc4jT-eecczr6vqOYVzCrK-mLxJ56CgpdBQEA-qBS3rpeAtPKwWAEwuFWf8pHqS0gYA2kbB4-qEtpzVQtaLauv82q1cDnFLnM8Yjc0ueLLC_APRk1sXzUCM74jFYZgHE8kUQ0bnE5l9h3FwmEheI4mYXMrGWyShJzmMJocSiA_edGbK2JXdyoyhSM4J09PqUW-GhM8O8bS6_vD-2-Wn5dWXj58v310traAqLyW3ikrLULUWBGPIO0Zba0HStmc1mJ52vDUNE62QTK6wKUcglDUSQUlan1Zv97rTvBqxs-hzaUlP0Y0mbnUwTv95491a34RbzYRUSski8PogEMP3GVPWo0u7aRiPYU66lG2hjP-_ICtGKfpL8ewvcBPm6MsUCkM5axrGC3Sxh2wMKUXs759MQe_M1zvz9dH8kvHy906P_MHtArw6ALvMo5zQjGolpSrEm38Tup-HIePPXNAXe3STyu-5ZzlwxWSjjsV6E7S5iS7p66-lvRqoqAWtZX0HlTjY0g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201425524</pqid></control><display><type>article</type><title>inhibitory interaction between viral and cellular proteins underlies the resistance of tomato to nonadapted tobamoviruses</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Ishibashi, Kazuhiro ; Naito, Satoshi ; Meshi, Tetsuo ; Ishikawa, Masayuki</creator><creatorcontrib>Ishibashi, Kazuhiro ; Naito, Satoshi ; Meshi, Tetsuo ; Ishikawa, Masayuki</creatorcontrib><description>Any individual virus can infect only a limited range of hosts, and most plant species are "nonhosts" to a given virus; i.e., all members of the species are insusceptible to the virus. In nonhost plants, the factors that control virus resistance are not genetically tractable, and how the host range of a virus is determined remains poorly understood. Tomato (Solanum lycopersicum) is a nonhost species for Tobacco mild green mosaic virus (TMGMV) and Pepper mild mottle virus (PMMoV), members of the genus TOBAMOVIRUS: Previously, we identified Tm-1, a resistance gene of tomato to another tobamovirus, Tomato mosaic virus (ToMV), and found that Tm-1 binds to ToMV replication proteins to inhibit RNA replication. Tm-1 is derived from a wild tomato species, S. habrochaites, and ToMV-susceptible tomato cultivars have the allelic gene tm-1. The tm-1 protein can neither bind to ToMV replication proteins nor inhibit ToMV multiplication. Here, we show that transgenic tobacco plants expressing tm-1 exhibit resistance to TMGMV and PMMoV. The tm-1 protein bound to the replication proteins of TMGMV and PMMoV and inhibited their RNA replication in vitro. In one of the tm-1-expressing tobacco plants, a tm-1-insensitive TMGMV mutant emerged. In tomato protoplasts, this mutant TMGMV multiplied as efficiently as ToMV. However, in tomato plants, the mutant TMGMV multiplied with lower efficiency compared to ToMV and caused systemic necrosis. These results suggest that an inhibitory interaction between the replication proteins and tm-1 underlies a multilayered resistance mechanism to TMGMV in tomato.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0809105106</identifier><identifier>PMID: 19423673</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adaptation, Biological ; binding proteins ; Biological Sciences ; Disease resistance ; gene expression ; Gene Expression Regulation, Viral ; Genes ; Genomics ; Host plants ; Host range ; host specificity ; host-pathogen relationships ; Leaves ; Lycopersicon esculentum ; Lycopersicon esculentum - genetics ; Lycopersicon esculentum - growth & development ; Lycopersicon esculentum - metabolism ; Lycopersicon esculentum - virology ; Mosaic viruses ; Mutation ; Mutation - genetics ; Nicotiana tabacum ; Pepper mild mottle virus ; Plant Diseases - virology ; plant proteins ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Plant viruses ; Plants ; Plants, Genetically Modified ; Protein Binding ; Proteins ; Protoplasts ; Replication ; replication proteins ; Ribonucleic acid ; RNA ; RNA, Viral - genetics ; Solanum ; Solanum habrochaites ; Solanum lycopersicum var. lycopersicum ; Systemic necrosis ; Tm-1 gene ; Tobacco ; Tobacco mild green mosaic virus ; Tobamovirus ; Tobamovirus - genetics ; Tobamovirus - metabolism ; Tomato mosaic virus ; Tomatoes ; transgenes ; Transgenic plants ; viral proteins ; Viral Proteins - genetics ; Viral Proteins - metabolism ; Viral RNA ; virus replication ; Virus Replication - genetics ; Viruses ; wild relatives</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (21), p.8778-8783</ispartof><rights>Copyright National Academy of Sciences May 26, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-74c817c2e89c0622e4d219cc0719f230af1d49a52696727be50af068ca7e08713</citedby><cites>FETCH-LOGICAL-c618t-74c817c2e89c0622e4d219cc0719f230af1d49a52696727be50af068ca7e08713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/106/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40482758$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40482758$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19423673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishibashi, Kazuhiro</creatorcontrib><creatorcontrib>Naito, Satoshi</creatorcontrib><creatorcontrib>Meshi, Tetsuo</creatorcontrib><creatorcontrib>Ishikawa, Masayuki</creatorcontrib><title>inhibitory interaction between viral and cellular proteins underlies the resistance of tomato to nonadapted tobamoviruses</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Any individual virus can infect only a limited range of hosts, and most plant species are "nonhosts" to a given virus; i.e., all members of the species are insusceptible to the virus. In nonhost plants, the factors that control virus resistance are not genetically tractable, and how the host range of a virus is determined remains poorly understood. Tomato (Solanum lycopersicum) is a nonhost species for Tobacco mild green mosaic virus (TMGMV) and Pepper mild mottle virus (PMMoV), members of the genus TOBAMOVIRUS: Previously, we identified Tm-1, a resistance gene of tomato to another tobamovirus, Tomato mosaic virus (ToMV), and found that Tm-1 binds to ToMV replication proteins to inhibit RNA replication. Tm-1 is derived from a wild tomato species, S. habrochaites, and ToMV-susceptible tomato cultivars have the allelic gene tm-1. The tm-1 protein can neither bind to ToMV replication proteins nor inhibit ToMV multiplication. Here, we show that transgenic tobacco plants expressing tm-1 exhibit resistance to TMGMV and PMMoV. The tm-1 protein bound to the replication proteins of TMGMV and PMMoV and inhibited their RNA replication in vitro. In one of the tm-1-expressing tobacco plants, a tm-1-insensitive TMGMV mutant emerged. In tomato protoplasts, this mutant TMGMV multiplied as efficiently as ToMV. However, in tomato plants, the mutant TMGMV multiplied with lower efficiency compared to ToMV and caused systemic necrosis. These results suggest that an inhibitory interaction between the replication proteins and tm-1 underlies a multilayered resistance mechanism to TMGMV in tomato.</description><subject>Adaptation, Biological</subject><subject>binding proteins</subject><subject>Biological Sciences</subject><subject>Disease resistance</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Viral</subject><subject>Genes</subject><subject>Genomics</subject><subject>Host plants</subject><subject>Host range</subject><subject>host specificity</subject><subject>host-pathogen relationships</subject><subject>Leaves</subject><subject>Lycopersicon esculentum</subject><subject>Lycopersicon esculentum - genetics</subject><subject>Lycopersicon esculentum - growth & development</subject><subject>Lycopersicon esculentum - metabolism</subject><subject>Lycopersicon esculentum - virology</subject><subject>Mosaic viruses</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>Nicotiana tabacum</subject><subject>Pepper mild mottle virus</subject><subject>Plant Diseases - virology</subject><subject>plant proteins</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Plant viruses</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Protoplasts</subject><subject>Replication</subject><subject>replication proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Viral - genetics</subject><subject>Solanum</subject><subject>Solanum habrochaites</subject><subject>Solanum lycopersicum var. lycopersicum</subject><subject>Systemic necrosis</subject><subject>Tm-1 gene</subject><subject>Tobacco</subject><subject>Tobacco mild green mosaic virus</subject><subject>Tobamovirus</subject><subject>Tobamovirus - genetics</subject><subject>Tobamovirus - metabolism</subject><subject>Tomato mosaic virus</subject><subject>Tomatoes</subject><subject>transgenes</subject><subject>Transgenic plants</subject><subject>viral proteins</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><subject>Viral RNA</subject><subject>virus replication</subject><subject>Virus Replication - genetics</subject><subject>Viruses</subject><subject>wild relatives</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhzAmwekBcth07ju1ckFDFl1SJA_RseZ1J16vEDrZT2H9fL7vqAgc4jT-eecczr6vqOYVzCrK-mLxJ56CgpdBQEA-qBS3rpeAtPKwWAEwuFWf8pHqS0gYA2kbB4-qEtpzVQtaLauv82q1cDnFLnM8Yjc0ueLLC_APRk1sXzUCM74jFYZgHE8kUQ0bnE5l9h3FwmEheI4mYXMrGWyShJzmMJocSiA_edGbK2JXdyoyhSM4J09PqUW-GhM8O8bS6_vD-2-Wn5dWXj58v310traAqLyW3ikrLULUWBGPIO0Zba0HStmc1mJ52vDUNE62QTK6wKUcglDUSQUlan1Zv97rTvBqxs-hzaUlP0Y0mbnUwTv95491a34RbzYRUSski8PogEMP3GVPWo0u7aRiPYU66lG2hjP-_ICtGKfpL8ewvcBPm6MsUCkM5axrGC3Sxh2wMKUXs759MQe_M1zvz9dH8kvHy906P_MHtArw6ALvMo5zQjGolpSrEm38Tup-HIePPXNAXe3STyu-5ZzlwxWSjjsV6E7S5iS7p66-lvRqoqAWtZX0HlTjY0g</recordid><startdate>20090526</startdate><enddate>20090526</enddate><creator>Ishibashi, Kazuhiro</creator><creator>Naito, Satoshi</creator><creator>Meshi, Tetsuo</creator><creator>Ishikawa, Masayuki</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090526</creationdate><title>inhibitory interaction between viral and cellular proteins underlies the resistance of tomato to nonadapted tobamoviruses</title><author>Ishibashi, Kazuhiro ; Naito, Satoshi ; Meshi, Tetsuo ; Ishikawa, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-74c817c2e89c0622e4d219cc0719f230af1d49a52696727be50af068ca7e08713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adaptation, Biological</topic><topic>binding proteins</topic><topic>Biological Sciences</topic><topic>Disease resistance</topic><topic>gene expression</topic><topic>Gene Expression Regulation, Viral</topic><topic>Genes</topic><topic>Genomics</topic><topic>Host plants</topic><topic>Host range</topic><topic>host specificity</topic><topic>host-pathogen relationships</topic><topic>Leaves</topic><topic>Lycopersicon esculentum</topic><topic>Lycopersicon esculentum - genetics</topic><topic>Lycopersicon esculentum - growth & development</topic><topic>Lycopersicon esculentum - metabolism</topic><topic>Lycopersicon esculentum - virology</topic><topic>Mosaic viruses</topic><topic>Mutation</topic><topic>Mutation - genetics</topic><topic>Nicotiana tabacum</topic><topic>Pepper mild mottle virus</topic><topic>Plant Diseases - virology</topic><topic>plant proteins</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Plant viruses</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Protoplasts</topic><topic>Replication</topic><topic>replication proteins</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Viral - genetics</topic><topic>Solanum</topic><topic>Solanum habrochaites</topic><topic>Solanum lycopersicum var. lycopersicum</topic><topic>Systemic necrosis</topic><topic>Tm-1 gene</topic><topic>Tobacco</topic><topic>Tobacco mild green mosaic virus</topic><topic>Tobamovirus</topic><topic>Tobamovirus - genetics</topic><topic>Tobamovirus - metabolism</topic><topic>Tomato mosaic virus</topic><topic>Tomatoes</topic><topic>transgenes</topic><topic>Transgenic plants</topic><topic>viral proteins</topic><topic>Viral Proteins - genetics</topic><topic>Viral Proteins - metabolism</topic><topic>Viral RNA</topic><topic>virus replication</topic><topic>Virus Replication - genetics</topic><topic>Viruses</topic><topic>wild relatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishibashi, Kazuhiro</creatorcontrib><creatorcontrib>Naito, Satoshi</creatorcontrib><creatorcontrib>Meshi, Tetsuo</creatorcontrib><creatorcontrib>Ishikawa, Masayuki</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishibashi, Kazuhiro</au><au>Naito, Satoshi</au><au>Meshi, Tetsuo</au><au>Ishikawa, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>inhibitory interaction between viral and cellular proteins underlies the resistance of tomato to nonadapted tobamoviruses</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2009-05-26</date><risdate>2009</risdate><volume>106</volume><issue>21</issue><spage>8778</spage><epage>8783</epage><pages>8778-8783</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Any individual virus can infect only a limited range of hosts, and most plant species are "nonhosts" to a given virus; i.e., all members of the species are insusceptible to the virus. In nonhost plants, the factors that control virus resistance are not genetically tractable, and how the host range of a virus is determined remains poorly understood. Tomato (Solanum lycopersicum) is a nonhost species for Tobacco mild green mosaic virus (TMGMV) and Pepper mild mottle virus (PMMoV), members of the genus TOBAMOVIRUS: Previously, we identified Tm-1, a resistance gene of tomato to another tobamovirus, Tomato mosaic virus (ToMV), and found that Tm-1 binds to ToMV replication proteins to inhibit RNA replication. Tm-1 is derived from a wild tomato species, S. habrochaites, and ToMV-susceptible tomato cultivars have the allelic gene tm-1. The tm-1 protein can neither bind to ToMV replication proteins nor inhibit ToMV multiplication. Here, we show that transgenic tobacco plants expressing tm-1 exhibit resistance to TMGMV and PMMoV. The tm-1 protein bound to the replication proteins of TMGMV and PMMoV and inhibited their RNA replication in vitro. In one of the tm-1-expressing tobacco plants, a tm-1-insensitive TMGMV mutant emerged. In tomato protoplasts, this mutant TMGMV multiplied as efficiently as ToMV. However, in tomato plants, the mutant TMGMV multiplied with lower efficiency compared to ToMV and caused systemic necrosis. These results suggest that an inhibitory interaction between the replication proteins and tm-1 underlies a multilayered resistance mechanism to TMGMV in tomato.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>19423673</pmid><doi>10.1073/pnas.0809105106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (21), p.8778-8783 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_19423673 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adaptation, Biological binding proteins Biological Sciences Disease resistance gene expression Gene Expression Regulation, Viral Genes Genomics Host plants Host range host specificity host-pathogen relationships Leaves Lycopersicon esculentum Lycopersicon esculentum - genetics Lycopersicon esculentum - growth & development Lycopersicon esculentum - metabolism Lycopersicon esculentum - virology Mosaic viruses Mutation Mutation - genetics Nicotiana tabacum Pepper mild mottle virus Plant Diseases - virology plant proteins Plant Proteins - genetics Plant Proteins - metabolism Plant viruses Plants Plants, Genetically Modified Protein Binding Proteins Protoplasts Replication replication proteins Ribonucleic acid RNA RNA, Viral - genetics Solanum Solanum habrochaites Solanum lycopersicum var. lycopersicum Systemic necrosis Tm-1 gene Tobacco Tobacco mild green mosaic virus Tobamovirus Tobamovirus - genetics Tobamovirus - metabolism Tomato mosaic virus Tomatoes transgenes Transgenic plants viral proteins Viral Proteins - genetics Viral Proteins - metabolism Viral RNA virus replication Virus Replication - genetics Viruses wild relatives |
| title | inhibitory interaction between viral and cellular proteins underlies the resistance of tomato to nonadapted tobamoviruses |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T04%3A04%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=inhibitory%20interaction%20between%20viral%20and%20cellular%20proteins%20underlies%20the%20resistance%20of%20tomato%20to%20nonadapted%20tobamoviruses&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Ishibashi,%20Kazuhiro&rft.date=2009-05-26&rft.volume=106&rft.issue=21&rft.spage=8778&rft.epage=8783&rft.pages=8778-8783&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0809105106&rft_dat=%3Cjstor_pubme%3E40482758%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201425524&rft_id=info:pmid/19423673&rft_jstor_id=40482758&rfr_iscdi=true |