Neutron-Activated Holmium-166-Poly (L-Lactic Acid) Microspheres: A Potential Agent for the Internal Radiation Therapy of Hepatic Tumors
Biodegradable Poly(L-lactic acid) microspheres containing neutron-activable 165Ho were designed for internal radiation therapy of hepatic tumors. Spheres composed of Poly(L-lactic acid) (PLA) were prepared with excellent reproducibility containing up to 36% of a holmium complex. The prepared spheres...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1991-11, Vol.32 (11), p.2139 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Mumper, Russell J Yun Ryo, U Jay, Michael |
| description | Biodegradable Poly(L-lactic acid) microspheres containing neutron-activable 165Ho were designed for internal radiation therapy of hepatic tumors. Spheres composed of Poly(L-lactic acid) (PLA) were prepared with excellent reproducibility containing up to 36% of a holmium complex. The prepared spheres were irradiated in a high neutron flux converting 165Ho to 166Ho (Emax = 1.84 MeV, half-life = 26.9 hr). Thus, these microspheres can be prepared under conditions that do not require the handling of a hazardous radionuclide, and then irradiated just prior to administration. In vitro studies in plasma (n = 6) revealed 97.3% (+/- 1.9) retention of 166Ho in the microspheres after 240 hr. PLA spheres administered via the portal vein in rabbits (n = 6) show 94.5% (+/- 3.4) retention of the original 166Ho activity in the liver after 6 days. |
| format | Article |
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Spheres composed of Poly(L-lactic acid) (PLA) were prepared with excellent reproducibility containing up to 36% of a holmium complex. The prepared spheres were irradiated in a high neutron flux converting 165Ho to 166Ho (Emax = 1.84 MeV, half-life = 26.9 hr). Thus, these microspheres can be prepared under conditions that do not require the handling of a hazardous radionuclide, and then irradiated just prior to administration. In vitro studies in plasma (n = 6) revealed 97.3% (+/- 1.9) retention of 166Ho in the microspheres after 240 hr. PLA spheres administered via the portal vein in rabbits (n = 6) show 94.5% (+/- 3.4) retention of the original 166Ho activity in the liver after 6 days.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 1941151</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Animals ; Biodegradation, Environmental ; Brachytherapy - methods ; Holmium - therapeutic use ; Lactates ; Lactic Acid ; Liver Neoplasms, Experimental - radiotherapy ; Microspheres ; Neutrons ; Polyesters ; Polymers ; Rabbits ; Radioisotopes - therapeutic use</subject><ispartof>The Journal of nuclear medicine (1978), 1991-11, Vol.32 (11), p.2139</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1941151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mumper, Russell J</creatorcontrib><creatorcontrib>Yun Ryo, U</creatorcontrib><creatorcontrib>Jay, Michael</creatorcontrib><title>Neutron-Activated Holmium-166-Poly (L-Lactic Acid) Microspheres: A Potential Agent for the Internal Radiation Therapy of Hepatic Tumors</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Biodegradable Poly(L-lactic acid) microspheres containing neutron-activable 165Ho were designed for internal radiation therapy of hepatic tumors. Spheres composed of Poly(L-lactic acid) (PLA) were prepared with excellent reproducibility containing up to 36% of a holmium complex. The prepared spheres were irradiated in a high neutron flux converting 165Ho to 166Ho (Emax = 1.84 MeV, half-life = 26.9 hr). Thus, these microspheres can be prepared under conditions that do not require the handling of a hazardous radionuclide, and then irradiated just prior to administration. In vitro studies in plasma (n = 6) revealed 97.3% (+/- 1.9) retention of 166Ho in the microspheres after 240 hr. PLA spheres administered via the portal vein in rabbits (n = 6) show 94.5% (+/- 3.4) retention of the original 166Ho activity in the liver after 6 days.</description><subject>Animals</subject><subject>Biodegradation, Environmental</subject><subject>Brachytherapy - methods</subject><subject>Holmium - therapeutic use</subject><subject>Lactates</subject><subject>Lactic Acid</subject><subject>Liver Neoplasms, Experimental - radiotherapy</subject><subject>Microspheres</subject><subject>Neutrons</subject><subject>Polyesters</subject><subject>Polymers</subject><subject>Rabbits</subject><subject>Radioisotopes - therapeutic use</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkEFLw0AQhRdRaq3-BGGP9RDIJNnNxlsoagtRi9Rz2GwmzZYkGzYbpb_Av21Ke3rD-2YezLsic2Ah8xjn8TWZ-8DBY8xnt-RuGA6-73MhxIzMIIkAGMzJ3weOzprOS5XTP9JhSdemafXYesC5tzXNkS4zL5MTVjRVunyi71pZM_Q1WhyeaUq3xmHntGxoup8GWhlLXY100zm03WR_yVJLp01Hd9OR7I_UVHSNvTxl7sbW2OGe3FSyGfDhogvy_fqyW6297PNts0ozrw7CxE1_CaWiCJJAJliJQLAqjhMIwGeyAKEiDCAWGAjB_aJMqhA5L2LGo1iFCcYQLsjjObcfixbLvLe6lfaYXwqZ-PLMa72vf7XFvBtVg9Kelg9dGwY5QB5AmIT_Ck5qmA</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Mumper, Russell J</creator><creator>Yun Ryo, U</creator><creator>Jay, Michael</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19911101</creationdate><title>Neutron-Activated Holmium-166-Poly (L-Lactic Acid) Microspheres: A Potential Agent for the Internal Radiation Therapy of Hepatic Tumors</title><author>Mumper, Russell J ; Yun Ryo, U ; Jay, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-568cc44192a9ef8285f77912105ab18c4e2178e28860bd9f3e66b75647c39e713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biodegradation, Environmental</topic><topic>Brachytherapy - methods</topic><topic>Holmium - therapeutic use</topic><topic>Lactates</topic><topic>Lactic Acid</topic><topic>Liver Neoplasms, Experimental - radiotherapy</topic><topic>Microspheres</topic><topic>Neutrons</topic><topic>Polyesters</topic><topic>Polymers</topic><topic>Rabbits</topic><topic>Radioisotopes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mumper, Russell J</creatorcontrib><creatorcontrib>Yun Ryo, U</creatorcontrib><creatorcontrib>Jay, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mumper, Russell J</au><au>Yun Ryo, U</au><au>Jay, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutron-Activated Holmium-166-Poly (L-Lactic Acid) Microspheres: A Potential Agent for the Internal Radiation Therapy of Hepatic Tumors</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>32</volume><issue>11</issue><spage>2139</spage><pages>2139-</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Biodegradable Poly(L-lactic acid) microspheres containing neutron-activable 165Ho were designed for internal radiation therapy of hepatic tumors. Spheres composed of Poly(L-lactic acid) (PLA) were prepared with excellent reproducibility containing up to 36% of a holmium complex. The prepared spheres were irradiated in a high neutron flux converting 165Ho to 166Ho (Emax = 1.84 MeV, half-life = 26.9 hr). Thus, these microspheres can be prepared under conditions that do not require the handling of a hazardous radionuclide, and then irradiated just prior to administration. In vitro studies in plasma (n = 6) revealed 97.3% (+/- 1.9) retention of 166Ho in the microspheres after 240 hr. PLA spheres administered via the portal vein in rabbits (n = 6) show 94.5% (+/- 3.4) retention of the original 166Ho activity in the liver after 6 days.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>1941151</pmid></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biodegradation, Environmental Brachytherapy - methods Holmium - therapeutic use Lactates Lactic Acid Liver Neoplasms, Experimental - radiotherapy Microspheres Neutrons Polyesters Polymers Rabbits Radioisotopes - therapeutic use |
| title | Neutron-Activated Holmium-166-Poly (L-Lactic Acid) Microspheres: A Potential Agent for the Internal Radiation Therapy of Hepatic Tumors |
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