Enhancement of sensitivity to hyperthermia by Lonidamine in human cancer cells
Human glioma (87MG) and squamous cell carcinoma of the head and neck UMSCC-1 were shown to be sensitized to hyperthermia by Lonidamine treatment before and during hyperthermia. The degree of thermal sensitization increased with increasing heating times and temperatures. In addition, the thermal sens...
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| Veröffentlicht in: | International journal of hyperthermia 1991, Vol.7 (5), p.763-772 |
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| container_title | International journal of hyperthermia |
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| creator | Raaphorst, G. P. Feeley, M. M. Martin, L. Danjoux, C. E. Maroun, J. Desanctis, A. J. Ko, D. |
| description | Human glioma (87MG) and squamous cell carcinoma of the head and neck UMSCC-1 were shown to be sensitized to hyperthermia by Lonidamine treatment before and during hyperthermia. The degree of thermal sensitization increased with increasing heating times and temperatures. In addition, the thermal sensitization by Lonidamine as well as cellular thermal sensitivity were dependent on pH and increased with the more acidic pH. Even though plateau phase cells were more thermally resistant than exponentially growing cells, Lonidamine treatment caused thermal sensitization under both conditions. These data show that Lonidamine may hold potential to enhance the effectiveness of hyperthermia in cancer treatment and that especially in tumours with low pH an enhanced therapeutic gain may be achieved. |
| doi_str_mv | 10.3109/02656739109056445 |
| format | Article |
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P. ; Feeley, M. M. ; Martin, L. ; Danjoux, C. E. ; Maroun, J. ; Desanctis, A. J. ; Ko, D.</creator><creatorcontrib>Raaphorst, G. P. ; Feeley, M. M. ; Martin, L. ; Danjoux, C. E. ; Maroun, J. ; Desanctis, A. J. ; Ko, D.</creatorcontrib><description>Human glioma (87MG) and squamous cell carcinoma of the head and neck UMSCC-1 were shown to be sensitized to hyperthermia by Lonidamine treatment before and during hyperthermia. The degree of thermal sensitization increased with increasing heating times and temperatures. In addition, the thermal sensitization by Lonidamine as well as cellular thermal sensitivity were dependent on pH and increased with the more acidic pH. Even though plateau phase cells were more thermally resistant than exponentially growing cells, Lonidamine treatment caused thermal sensitization under both conditions. These data show that Lonidamine may hold potential to enhance the effectiveness of hyperthermia in cancer treatment and that especially in tumours with low pH an enhanced therapeutic gain may be achieved.</description><identifier>ISSN: 0265-6736</identifier><identifier>EISSN: 1464-5157</identifier><identifier>DOI: 10.3109/02656739109056445</identifier><identifier>PMID: 1940511</identifier><identifier>CODEN: IJHYEQ</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Carcinoma, Squamous Cell - therapy ; Cell Survival ; Combined Modality Therapy ; Drug Synergism ; Glioma - therapy ; human tumour cells ; Humans ; Hydrogen-Ion Concentration ; hyperthermia ; Hyperthermia, Induced - methods ; Indazoles - pharmacology ; Lonidamine pH ; Medical sciences ; Radiation-Sensitizing Agents - pharmacology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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P.</creatorcontrib><creatorcontrib>Feeley, M. M.</creatorcontrib><creatorcontrib>Martin, L.</creatorcontrib><creatorcontrib>Danjoux, C. E.</creatorcontrib><creatorcontrib>Maroun, J.</creatorcontrib><creatorcontrib>Desanctis, A. J.</creatorcontrib><creatorcontrib>Ko, D.</creatorcontrib><title>Enhancement of sensitivity to hyperthermia by Lonidamine in human cancer cells</title><title>International journal of hyperthermia</title><addtitle>Int J Hyperthermia</addtitle><description>Human glioma (87MG) and squamous cell carcinoma of the head and neck UMSCC-1 were shown to be sensitized to hyperthermia by Lonidamine treatment before and during hyperthermia. The degree of thermal sensitization increased with increasing heating times and temperatures. In addition, the thermal sensitization by Lonidamine as well as cellular thermal sensitivity were dependent on pH and increased with the more acidic pH. Even though plateau phase cells were more thermally resistant than exponentially growing cells, Lonidamine treatment caused thermal sensitization under both conditions. These data show that Lonidamine may hold potential to enhance the effectiveness of hyperthermia in cancer treatment and that especially in tumours with low pH an enhanced therapeutic gain may be achieved.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cell Survival</subject><subject>Combined Modality Therapy</subject><subject>Drug Synergism</subject><subject>Glioma - therapy</subject><subject>human tumour cells</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>hyperthermia</subject><subject>Hyperthermia, Induced - methods</subject><subject>Indazoles - pharmacology</subject><subject>Lonidamine pH</subject><subject>Medical sciences</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0265-6736</issn><issn>1464-5157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoc04_gA9CHnytJk2aLOiLjPkHhr7oc0nShGa06Ug6pd_ejE5FBJ_uhXN-l3sOAOcYXRGMxDXKWcE4EWlHBaO0OABTTBnNClzwQzDd6VkysGNwEuMaIUSLnE_ABAuKCoyn4Hnpa-m1aY3vYWdhND663r27foB9B-thY0Jfm9A6CdUAV513lWydN9B5WG9b6aHe8QFq0zTxFBxZ2URztp8z8Ha_fF08ZquXh6fF3SrTlKA-mxOSGyUFF1xhUVEuESdIKaIY11hLIgSxGmFpreDWIi5MPmemYiqJVYXIDODxrg5djMHYchNcK8NQYlTuqin_VJOYi5HZbFVrqh9i7CLpl3tdRi0bG1IuF79tBeFCMJJst6PNeduFVn50oanKXg5NF74Y8t8XN7_w2simr7UMplx32-BTa_9k-ATpkpF2</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Raaphorst, G. P.</creator><creator>Feeley, M. M.</creator><creator>Martin, L.</creator><creator>Danjoux, C. E.</creator><creator>Maroun, J.</creator><creator>Desanctis, A. J.</creator><creator>Ko, D.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1991</creationdate><title>Enhancement of sensitivity to hyperthermia by Lonidamine in human cancer cells</title><author>Raaphorst, G. P. ; Feeley, M. M. ; Martin, L. ; Danjoux, C. E. ; Maroun, J. ; Desanctis, A. J. ; Ko, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-8332eba9797b19d47a0730bb3b67c1ca3993fc01aff97ff079e286ed6b1cadd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cell Survival</topic><topic>Combined Modality Therapy</topic><topic>Drug Synergism</topic><topic>Glioma - therapy</topic><topic>human tumour cells</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>hyperthermia</topic><topic>Hyperthermia, Induced - methods</topic><topic>Indazoles - pharmacology</topic><topic>Lonidamine pH</topic><topic>Medical sciences</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. 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J.</creatorcontrib><creatorcontrib>Ko, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of hyperthermia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raaphorst, G. P.</au><au>Feeley, M. M.</au><au>Martin, L.</au><au>Danjoux, C. E.</au><au>Maroun, J.</au><au>Desanctis, A. J.</au><au>Ko, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of sensitivity to hyperthermia by Lonidamine in human cancer cells</atitle><jtitle>International journal of hyperthermia</jtitle><addtitle>Int J Hyperthermia</addtitle><date>1991</date><risdate>1991</risdate><volume>7</volume><issue>5</issue><spage>763</spage><epage>772</epage><pages>763-772</pages><issn>0265-6736</issn><eissn>1464-5157</eissn><coden>IJHYEQ</coden><abstract>Human glioma (87MG) and squamous cell carcinoma of the head and neck UMSCC-1 were shown to be sensitized to hyperthermia by Lonidamine treatment before and during hyperthermia. The degree of thermal sensitization increased with increasing heating times and temperatures. In addition, the thermal sensitization by Lonidamine as well as cellular thermal sensitivity were dependent on pH and increased with the more acidic pH. Even though plateau phase cells were more thermally resistant than exponentially growing cells, Lonidamine treatment caused thermal sensitization under both conditions. These data show that Lonidamine may hold potential to enhance the effectiveness of hyperthermia in cancer treatment and that especially in tumours with low pH an enhanced therapeutic gain may be achieved.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>1940511</pmid><doi>10.3109/02656739109056445</doi><tpages>10</tpages></addata></record> |
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| ispartof | International journal of hyperthermia, 1991, Vol.7 (5), p.763-772 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Squamous Cell - therapy Cell Survival Combined Modality Therapy Drug Synergism Glioma - therapy human tumour cells Humans Hydrogen-Ion Concentration hyperthermia Hyperthermia, Induced - methods Indazoles - pharmacology Lonidamine pH Medical sciences Radiation-Sensitizing Agents - pharmacology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Time Factors Tumor Cells, Cultured - drug effects |
| title | Enhancement of sensitivity to hyperthermia by Lonidamine in human cancer cells |
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