Dietary ammonium chloride for the acidification of mouse urine

A novel therapeutic compound was found to induce bladder tumors in male rats. Given the location of the tumors and the increased amounts of calcium- and magnesium-containing solids found in the urine of treated animals, we hypothesized that tumorigenesis was secondary to urine crystal formation rath...

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Veröffentlicht in:	Journal of the American Association for Laboratory Animal Science 2009-03, Vol.48 (2), p.144-146
Hauptverfasser:	Reisinger, Amy J, Tannehill-Gregg, Sarah H, Waites, C. Robbie, Dominick, Mark A, Schilling, Beth E, Jackson, Todd A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - drug effects acidification ammonium chloride Ammonium Chloride - administration & dosage Animal Feed Animals Biology Hydrogen-Ion Concentration - drug effects Male Mice Mice, Inbred Strains oral administration Specific Pathogen-Free Organisms temporal variation urinary pH urine Urine - chemistry
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