Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA

The x-ray crystal structure of the thiostrepton resistance RNA methyltransferase (Tsr).S-adenosyl-L-methionine (AdoMet) complex was determined at 2.45-A resolution. Tsr is definitively confirmed as a Class IV methyltransferase of the SpoU family with an N-terminal "L30-like" putative targe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2009-06, Vol.284 (25), p.17013
Hauptverfasser:	Dunstan, Mark S, Hang, Pei C, Zelinskaya, Natalia V, Honek, John F, Conn, Graeme L
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Catalytic Domain Crystallography, X-Ray Dimerization Drug Resistance, Bacterial Macromolecular Substances Methyltransferases - chemistry Methyltransferases - genetics Methyltransferases - metabolism Models, Molecular Nucleic Acid Conformation Protein Structure, Quaternary Protein Structure, Secondary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Ribosomal, 23S - chemistry RNA, Ribosomal, 23S - genetics RNA, Ribosomal, 23S - metabolism S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Staphylococcus aureus - genetics Static Electricity Thiostrepton - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!