single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function

Aurora kinase-A and -B are key regulators of the cell cycle and tumorigenesis. It has remained a mystery why these 2 Aurora kinases, although highly similar in protein sequence and structure, are distinct in subcellular localization and function. Here, we report the striking finding that a single am...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-04, Vol.106 (17), p.6939-6944
Hauptverfasser:	Fu, Jingyan, Bian, Minglei, Liu, Junjun, Jiang, Qing, Zhang, Chuanmao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Amino Acids - genetics Amino Acids - metabolism Antibodies Aurora Kinase A Aurora Kinase B Aurora Kinases Biological Sciences Cell cycle Cell division Cell lines Cells Centromeres Chromosomal Proteins, Non-Histone - metabolism Chromosome Structures - metabolism Chromosomes Conserved Sequence Enzyme Activation Glycine - genetics Glycine - metabolism HeLa Cells Humans Kinases Microtubule-Associated Proteins - metabolism Mitosis Mitotic spindle apparatus Models, Molecular Molecular structure Passengers Phosphorylation Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Sequence Alignment Substrate Specificity
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