Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer
Summary Human tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 ( KLK7 ) has been purified...
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| Veröffentlicht in: | Thrombosis and haemostasis 2009-04, Vol.101 (4), p.741-747 |
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| creator | Talieri, Maroulio Mathioudaki, Konstantina Prezas, Panagiotis Alexopoulou, Dimitra K. Diamandis, Eleftherios P. Xynopoulos, Dimitris Ardavanis, Alexandros Arnogiannaki, Niki Scorilas, Andreas |
| description | Summary
Human tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 (
KLK7
) has been purified from human stratum corneum and resembles a chymotryptic endopeptidase originally called stratum corneum chymotryptic enzyme (SCCE). In this study, we examined for the first time, the prognostic value of
KLK7
mRNA expression, using a semi-quantitative RT-PCR method, in 105 colorectal cancer tissues for 54 of which, paired normal colonic mucosa were available. Furthermore, we analysed the expression of
KLK7
in 10 adenomas, in 18 biopsies of inflamed colon mucosa, as well as in 22 human cancer cell lines of various origin, four of them being of colon. A defined number of colon cancer samples were also examined by immunohisto-chemistry.
KLK7
expression was higher in cancerous than in normal tissues. Less differentiated tumors of more advanced stage showed higher
KLK7
expression. Follow-up analysis revealed that
KLK7
was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). In addition, selected colon cancer samples highly expressing
KLK7
gene, showed intense immunohistochemical staining for KLK7, enhancing RTPCR results. Present data suggest that
KLK7
gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients. |
| doi_str_mv | 10.1160/TH08-07-0471 |
| format | Article |
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Human tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 (
KLK7
) has been purified from human stratum corneum and resembles a chymotryptic endopeptidase originally called stratum corneum chymotryptic enzyme (SCCE). In this study, we examined for the first time, the prognostic value of
KLK7
mRNA expression, using a semi-quantitative RT-PCR method, in 105 colorectal cancer tissues for 54 of which, paired normal colonic mucosa were available. Furthermore, we analysed the expression of
KLK7
in 10 adenomas, in 18 biopsies of inflamed colon mucosa, as well as in 22 human cancer cell lines of various origin, four of them being of colon. A defined number of colon cancer samples were also examined by immunohisto-chemistry.
KLK7
expression was higher in cancerous than in normal tissues. Less differentiated tumors of more advanced stage showed higher
KLK7
expression. Follow-up analysis revealed that
KLK7
was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). In addition, selected colon cancer samples highly expressing
KLK7
gene, showed intense immunohistochemical staining for KLK7, enhancing RTPCR results. Present data suggest that
KLK7
gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH08-07-0471</identifier><identifier>PMID: 19350120</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adenoma - enzymology ; Adenoma - genetics ; Adenoma - mortality ; Adenoma - pathology ; Adenoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Blood coagulation. Blood cells ; Cell lines ; Cellular Proteolysis and Oncology ; Colitis - enzymology ; Colitis - genetics ; Colorectal Cancer ; Colorectal Neoplasms - enzymology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Disease-Free Survival ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Hematologic and hematopoietic diseases ; HT29 Cells ; human stratum corneum chymotryptic enzyme ; Humans ; Immunohistochemistry ; Intestinal Mucosa - enzymology ; Kallikreins - analysis ; Kallikreins - genetics ; Kaplan-Meier Estimate ; KLK7 ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Neoplasm Staging ; Platelet diseases and coagulopathies ; Proportional Hazards Models ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Assessment ; Risk Factors ; RNA, Messenger - analysis ; Time Factors ; Treatment Outcome ; tumor markers ; Up-Regulation</subject><ispartof>Thrombosis and haemostasis, 2009-04, Vol.101 (4), p.741-747</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-e643c71e7d25a2b62ac1bc53845bcc307b8444edef032b1352eac785317c9cb73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH08-07-0471.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH08-07-0471$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21284849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19350120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talieri, Maroulio</creatorcontrib><creatorcontrib>Mathioudaki, Konstantina</creatorcontrib><creatorcontrib>Prezas, Panagiotis</creatorcontrib><creatorcontrib>Alexopoulou, Dimitra K.</creatorcontrib><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><creatorcontrib>Xynopoulos, Dimitris</creatorcontrib><creatorcontrib>Ardavanis, Alexandros</creatorcontrib><creatorcontrib>Arnogiannaki, Niki</creatorcontrib><creatorcontrib>Scorilas, Andreas</creatorcontrib><title>Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Human tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 (
KLK7
) has been purified from human stratum corneum and resembles a chymotryptic endopeptidase originally called stratum corneum chymotryptic enzyme (SCCE). In this study, we examined for the first time, the prognostic value of
KLK7
mRNA expression, using a semi-quantitative RT-PCR method, in 105 colorectal cancer tissues for 54 of which, paired normal colonic mucosa were available. Furthermore, we analysed the expression of
KLK7
in 10 adenomas, in 18 biopsies of inflamed colon mucosa, as well as in 22 human cancer cell lines of various origin, four of them being of colon. A defined number of colon cancer samples were also examined by immunohisto-chemistry.
KLK7
expression was higher in cancerous than in normal tissues. Less differentiated tumors of more advanced stage showed higher
KLK7
expression. Follow-up analysis revealed that
KLK7
was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). In addition, selected colon cancer samples highly expressing
KLK7
gene, showed intense immunohistochemical staining for KLK7, enhancing RTPCR results. Present data suggest that
KLK7
gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients.</description><subject>Adenoma - enzymology</subject><subject>Adenoma - genetics</subject><subject>Adenoma - mortality</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Blood coagulation. Blood cells</subject><subject>Cell lines</subject><subject>Cellular Proteolysis and Oncology</subject><subject>Colitis - enzymology</subject><subject>Colitis - genetics</subject><subject>Colorectal Cancer</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Disease-Free Survival</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>HCT116 Cells</subject><subject>Hematologic and hematopoietic diseases</subject><subject>HT29 Cells</subject><subject>human stratum corneum chymotryptic enzyme</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Kallikreins - analysis</subject><subject>Kallikreins - genetics</subject><subject>Kaplan-Meier Estimate</subject><subject>KLK7</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Neoplasm Staging</subject><subject>Platelet diseases and coagulopathies</subject><subject>Proportional Hazards Models</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>RNA, Messenger - analysis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>tumor markers</subject><subject>Up-Regulation</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqtkM-L1DAYhoMo7rh68yy9KIpW87NpjzKoKzvgwRW8hTT9ajObJt0kVfzvzTjDehBvnpKQ53sfvhehxwS_JqTBb64ucFtjWWMuyR20oaKRddN2X--iDWYc1w3l4gw9SGmPMWl4J-6jM9IxgQnFG_R566y3Rrsq2W_ejuXqDVRhrK61c_Y6gvV1BKczDNUCS7aDTlDJ6vnl7lK-qKyvTHAhgskl4_dwfIjujdoleHQ6z9GX9--uthf17tOHj9u3u9oILnMNDWdGEpADFZr2DdWG9EawloveGIZl33LOYYARM9oTJihoI1vBiDSd6SU7R8-OuUsMNyukrGabDDinPYQ1qUYSwigmBXx1BE0MKUUY1RLtrONPRbA6lKgOJSos1aHEgj855a79DMMf-NRaAZ6eAJ1KdWMsa9t0y1FCW97yrnAvj1yeLMyg9mGNvjTyL-3-SCcz6Zz1CvE2Mk8xzH1IxaL9oCYNc0hZH94m-Aw-l49oJvsdlE1pBSVJq2bt12SiXXLREcxUmsIPNeXZFdnwH2VpAWO1-0vIfgHukdec</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Talieri, Maroulio</creator><creator>Mathioudaki, Konstantina</creator><creator>Prezas, Panagiotis</creator><creator>Alexopoulou, Dimitra K.</creator><creator>Diamandis, Eleftherios P.</creator><creator>Xynopoulos, Dimitris</creator><creator>Ardavanis, Alexandros</creator><creator>Arnogiannaki, Niki</creator><creator>Scorilas, Andreas</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer</title><author>Talieri, Maroulio ; Mathioudaki, Konstantina ; Prezas, Panagiotis ; Alexopoulou, Dimitra K. ; Diamandis, Eleftherios P. ; Xynopoulos, Dimitris ; Ardavanis, Alexandros ; Arnogiannaki, Niki ; Scorilas, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-e643c71e7d25a2b62ac1bc53845bcc307b8444edef032b1352eac785317c9cb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenoma - enzymology</topic><topic>Adenoma - genetics</topic><topic>Adenoma - mortality</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Blood coagulation. Blood cells</topic><topic>Cell lines</topic><topic>Cellular Proteolysis and Oncology</topic><topic>Colitis - enzymology</topic><topic>Colitis - genetics</topic><topic>Colorectal Cancer</topic><topic>Colorectal Neoplasms - enzymology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Disease-Free Survival</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>HCT116 Cells</topic><topic>Hematologic and hematopoietic diseases</topic><topic>HT29 Cells</topic><topic>human stratum corneum chymotryptic enzyme</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Kallikreins - analysis</topic><topic>Kallikreins - genetics</topic><topic>Kaplan-Meier Estimate</topic><topic>KLK7</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Neoplasm Staging</topic><topic>Platelet diseases and coagulopathies</topic><topic>Proportional Hazards Models</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>RNA, Messenger - analysis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>tumor markers</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talieri, Maroulio</creatorcontrib><creatorcontrib>Mathioudaki, Konstantina</creatorcontrib><creatorcontrib>Prezas, Panagiotis</creatorcontrib><creatorcontrib>Alexopoulou, Dimitra K.</creatorcontrib><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><creatorcontrib>Xynopoulos, Dimitris</creatorcontrib><creatorcontrib>Ardavanis, Alexandros</creatorcontrib><creatorcontrib>Arnogiannaki, Niki</creatorcontrib><creatorcontrib>Scorilas, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talieri, Maroulio</au><au>Mathioudaki, Konstantina</au><au>Prezas, Panagiotis</au><au>Alexopoulou, Dimitra K.</au><au>Diamandis, Eleftherios P.</au><au>Xynopoulos, Dimitris</au><au>Ardavanis, Alexandros</au><au>Arnogiannaki, Niki</au><au>Scorilas, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>101</volume><issue>4</issue><spage>741</spage><epage>747</epage><pages>741-747</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Summary
Human tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 (
KLK7
) has been purified from human stratum corneum and resembles a chymotryptic endopeptidase originally called stratum corneum chymotryptic enzyme (SCCE). In this study, we examined for the first time, the prognostic value of
KLK7
mRNA expression, using a semi-quantitative RT-PCR method, in 105 colorectal cancer tissues for 54 of which, paired normal colonic mucosa were available. Furthermore, we analysed the expression of
KLK7
in 10 adenomas, in 18 biopsies of inflamed colon mucosa, as well as in 22 human cancer cell lines of various origin, four of them being of colon. A defined number of colon cancer samples were also examined by immunohisto-chemistry.
KLK7
expression was higher in cancerous than in normal tissues. Less differentiated tumors of more advanced stage showed higher
KLK7
expression. Follow-up analysis revealed that
KLK7
was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). In addition, selected colon cancer samples highly expressing
KLK7
gene, showed intense immunohistochemical staining for KLK7, enhancing RTPCR results. Present data suggest that
KLK7
gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>19350120</pmid><doi>10.1160/TH08-07-0471</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6245 |
| ispartof | Thrombosis and haemostasis, 2009-04, Vol.101 (4), p.741-747 |
| issn | 0340-6245 2567-689X |
| language | eng |
| recordid | cdi_pubmed_primary_19350120 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Adenoma - enzymology Adenoma - genetics Adenoma - mortality Adenoma - pathology Adenoma - surgery Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Blood coagulation. Blood cells Cell lines Cellular Proteolysis and Oncology Colitis - enzymology Colitis - genetics Colorectal Cancer Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Disease-Free Survival Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic HCT116 Cells Hematologic and hematopoietic diseases HT29 Cells human stratum corneum chymotryptic enzyme Humans Immunohistochemistry Intestinal Mucosa - enzymology Kallikreins - analysis Kallikreins - genetics Kaplan-Meier Estimate KLK7 Medical sciences Middle Aged Molecular and cellular biology Neoplasm Staging Platelet diseases and coagulopathies Proportional Hazards Models Reverse Transcriptase Polymerase Chain Reaction Risk Assessment Risk Factors RNA, Messenger - analysis Time Factors Treatment Outcome tumor markers Up-Regulation |
| title | Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer |
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