Cell-Mediated Immunity in Cervical Cancer Evolution
Cell-mediated immunity (CMI) response to different antigens was examined in healthy women, in patients with cervical precancerous lesions, and in patients with cervical cancer. Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from "punch" bio...
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| Veröffentlicht in: | Electromagnetic biology and medicine 2009, Vol.28 (1), p.1-14 |
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| creator | Jandová, A. Pokorný, J. Kobilková, J. Janoušek, M. Mašata, J. Trojan, S. Nedbalová, M. Dohnalová, A. Beková, A. Slavík, V. o ek, A. Sanitrák, J. |
| description | Cell-mediated immunity (CMI) response to different antigens was examined in healthy women, in patients with cervical precancerous lesions, and in patients with cervical cancer. Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from "punch" biopsy material by histology. CMI response is related to specific processes in healthy and cancer cells. CMI was investigated by leukocyte adherence inhibition (LAI) assay using specific antigen (prepared from cervical carcinoma tissue) and non specific antigen (prepared from blood of mice infected by LDH-lactate dehydrogenase-virus). The CMI responses of healthy women and cancer patients to the antigens used are different: the majority of T lymphocytes display adherence and non adherence, respectively (but the CMI responses elicited by the antigens are not equal and small quantitative differences are observed). Regardless of the CIN (cervical intraepithelial neoplasia) grades, CMI responses correspond either to healthy women or to cervical carcinoma patients (at about similar ratio of cases in all the CIN groups). Effect of non specific antigen suggests that cervical carcinoma transformation may be connected with reduction of mitochondrial activity similar to processes in LDH virus infection. |
| doi_str_mv | 10.1080/15368370802708868 |
| format | Article |
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Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from "punch" biopsy material by histology. CMI response is related to specific processes in healthy and cancer cells. CMI was investigated by leukocyte adherence inhibition (LAI) assay using specific antigen (prepared from cervical carcinoma tissue) and non specific antigen (prepared from blood of mice infected by LDH-lactate dehydrogenase-virus). The CMI responses of healthy women and cancer patients to the antigens used are different: the majority of T lymphocytes display adherence and non adherence, respectively (but the CMI responses elicited by the antigens are not equal and small quantitative differences are observed). Regardless of the CIN (cervical intraepithelial neoplasia) grades, CMI responses correspond either to healthy women or to cervical carcinoma patients (at about similar ratio of cases in all the CIN groups). Effect of non specific antigen suggests that cervical carcinoma transformation may be connected with reduction of mitochondrial activity similar to processes in LDH virus infection.</description><identifier>ISSN: 1536-8378</identifier><identifier>EISSN: 1536-8386</identifier><identifier>DOI: 10.1080/15368370802708868</identifier><identifier>PMID: 19337890</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Antigens, Neoplasm - metabolism ; Cell Adhesion ; Cell-mediated immunity ; Cervical cancer evolution ; Cervical precancerous lesions ; Chromatography, High Pressure Liquid ; Female ; Humans ; Immunity, Cellular ; L-Lactate Dehydrogenase - metabolism ; Lactate dehydrogenase-elevating virus - metabolism ; Leukocyte adherence inhibition assay ; Leukocytes - cytology ; Mitochondria - metabolism ; Precancerous Conditions ; T-Lymphocytes - pathology ; T-Lymphocytes - virology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - immunology ; Uterine Cervical Neoplasms - pathology ; Warburg effect, High-pressure gel chromatography</subject><ispartof>Electromagnetic biology and medicine, 2009, Vol.28 (1), p.1-14</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-93b6d5bafbfdf498169bbe0d9813adfb9c34a4c43a080f52be41a530d5ff4ab53</citedby><cites>FETCH-LOGICAL-c404t-93b6d5bafbfdf498169bbe0d9813adfb9c34a4c43a080f52be41a530d5ff4ab53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/15368370802708868$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/15368370802708868$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,781,785,4025,27928,27929,27930,59652,59758,60441,60547,61226,61261,61407,61442</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19337890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jandová, A.</creatorcontrib><creatorcontrib>Pokorný, J.</creatorcontrib><creatorcontrib>Kobilková, J.</creatorcontrib><creatorcontrib>Janoušek, M.</creatorcontrib><creatorcontrib>Mašata, J.</creatorcontrib><creatorcontrib>Trojan, S.</creatorcontrib><creatorcontrib>Nedbalová, M.</creatorcontrib><creatorcontrib>Dohnalová, A.</creatorcontrib><creatorcontrib>Beková, A.</creatorcontrib><creatorcontrib>Slavík, V.</creatorcontrib><creatorcontrib>o ek, A.</creatorcontrib><creatorcontrib>Sanitrák, J.</creatorcontrib><title>Cell-Mediated Immunity in Cervical Cancer Evolution</title><title>Electromagnetic biology and medicine</title><addtitle>Electromagn Biol Med</addtitle><description>Cell-mediated immunity (CMI) response to different antigens was examined in healthy women, in patients with cervical precancerous lesions, and in patients with cervical cancer. Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from "punch" biopsy material by histology. CMI response is related to specific processes in healthy and cancer cells. CMI was investigated by leukocyte adherence inhibition (LAI) assay using specific antigen (prepared from cervical carcinoma tissue) and non specific antigen (prepared from blood of mice infected by LDH-lactate dehydrogenase-virus). The CMI responses of healthy women and cancer patients to the antigens used are different: the majority of T lymphocytes display adherence and non adherence, respectively (but the CMI responses elicited by the antigens are not equal and small quantitative differences are observed). Regardless of the CIN (cervical intraepithelial neoplasia) grades, CMI responses correspond either to healthy women or to cervical carcinoma patients (at about similar ratio of cases in all the CIN groups). Effect of non specific antigen suggests that cervical carcinoma transformation may be connected with reduction of mitochondrial activity similar to processes in LDH virus infection.</description><subject>Antigens, Neoplasm - metabolism</subject><subject>Cell Adhesion</subject><subject>Cell-mediated immunity</subject><subject>Cervical cancer evolution</subject><subject>Cervical precancerous lesions</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Lactate dehydrogenase-elevating virus - metabolism</subject><subject>Leukocyte adherence inhibition assay</subject><subject>Leukocytes - cytology</subject><subject>Mitochondria - metabolism</subject><subject>Precancerous Conditions</subject><subject>T-Lymphocytes - pathology</subject><subject>T-Lymphocytes - virology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - immunology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Warburg effect, High-pressure gel chromatography</subject><issn>1536-8378</issn><issn>1536-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMotlYfwI3Myt1o0mRmEnQjQ9VCxY2uQ35pysykJjOVvr0pLYoIbpLD5ZzDvR8AlwjeIEjhLSpwSXGV5DQ9tKRHYLyb5RTT8vhbV3QEzmJcQYhYBfEpGCGG05TBMcC1aZr8xWgneqOzedsOneu3meuy2oSNU6LJatEpE7LZxjdD73x3Dk6saKK5OPwT8P44e6uf88Xr07x-WOSKQNLnDMtSF1JYabUljKKSSWmgTgoLbSVTmAiiCBbpAFtMpSFIFBjqwloiZIEn4Hrfuw7-YzCx562LKu0rOuOHyMsKMsJKlIxob1TBxxiM5evgWhG2HEG-I8X_kEqZq0P5IFujfxIHNMlwvze4zvrQik8fGs17sW18sCEhcZHj__rvfsWXRjT9Uolg-MoPoUvg_tnuC2wuiKA</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Jandová, A.</creator><creator>Pokorný, J.</creator><creator>Kobilková, J.</creator><creator>Janoušek, M.</creator><creator>Mašata, J.</creator><creator>Trojan, S.</creator><creator>Nedbalová, M.</creator><creator>Dohnalová, A.</creator><creator>Beková, A.</creator><creator>Slavík, V.</creator><creator>o ek, A.</creator><creator>Sanitrák, J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Cell-Mediated Immunity in Cervical Cancer Evolution</title><author>Jandová, A. ; Pokorný, J. ; Kobilková, J. ; Janoušek, M. ; Mašata, J. ; Trojan, S. ; Nedbalová, M. ; Dohnalová, A. ; Beková, A. ; Slavík, V. ; o ek, A. ; Sanitrák, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-93b6d5bafbfdf498169bbe0d9813adfb9c34a4c43a080f52be41a530d5ff4ab53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antigens, Neoplasm - metabolism</topic><topic>Cell Adhesion</topic><topic>Cell-mediated immunity</topic><topic>Cervical cancer evolution</topic><topic>Cervical precancerous lesions</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Lactate dehydrogenase-elevating virus - metabolism</topic><topic>Leukocyte adherence inhibition assay</topic><topic>Leukocytes - cytology</topic><topic>Mitochondria - metabolism</topic><topic>Precancerous Conditions</topic><topic>T-Lymphocytes - pathology</topic><topic>T-Lymphocytes - virology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - immunology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Warburg effect, High-pressure gel chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jandová, A.</creatorcontrib><creatorcontrib>Pokorný, J.</creatorcontrib><creatorcontrib>Kobilková, J.</creatorcontrib><creatorcontrib>Janoušek, M.</creatorcontrib><creatorcontrib>Mašata, J.</creatorcontrib><creatorcontrib>Trojan, S.</creatorcontrib><creatorcontrib>Nedbalová, M.</creatorcontrib><creatorcontrib>Dohnalová, A.</creatorcontrib><creatorcontrib>Beková, A.</creatorcontrib><creatorcontrib>Slavík, V.</creatorcontrib><creatorcontrib>o ek, A.</creatorcontrib><creatorcontrib>Sanitrák, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Electromagnetic biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jandová, A.</au><au>Pokorný, J.</au><au>Kobilková, J.</au><au>Janoušek, M.</au><au>Mašata, J.</au><au>Trojan, S.</au><au>Nedbalová, M.</au><au>Dohnalová, A.</au><au>Beková, A.</au><au>Slavík, V.</au><au>o ek, A.</au><au>Sanitrák, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell-Mediated Immunity in Cervical Cancer Evolution</atitle><jtitle>Electromagnetic biology and medicine</jtitle><addtitle>Electromagn Biol Med</addtitle><date>2009</date><risdate>2009</risdate><volume>28</volume><issue>1</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1536-8378</issn><eissn>1536-8386</eissn><abstract>Cell-mediated immunity (CMI) response to different antigens was examined in healthy women, in patients with cervical precancerous lesions, and in patients with cervical cancer. Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from "punch" biopsy material by histology. CMI response is related to specific processes in healthy and cancer cells. CMI was investigated by leukocyte adherence inhibition (LAI) assay using specific antigen (prepared from cervical carcinoma tissue) and non specific antigen (prepared from blood of mice infected by LDH-lactate dehydrogenase-virus). The CMI responses of healthy women and cancer patients to the antigens used are different: the majority of T lymphocytes display adherence and non adherence, respectively (but the CMI responses elicited by the antigens are not equal and small quantitative differences are observed). Regardless of the CIN (cervical intraepithelial neoplasia) grades, CMI responses correspond either to healthy women or to cervical carcinoma patients (at about similar ratio of cases in all the CIN groups). Effect of non specific antigen suggests that cervical carcinoma transformation may be connected with reduction of mitochondrial activity similar to processes in LDH virus infection.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19337890</pmid><doi>10.1080/15368370802708868</doi><tpages>14</tpages></addata></record> |
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| subjects | Antigens, Neoplasm - metabolism Cell Adhesion Cell-mediated immunity Cervical cancer evolution Cervical precancerous lesions Chromatography, High Pressure Liquid Female Humans Immunity, Cellular L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase-elevating virus - metabolism Leukocyte adherence inhibition assay Leukocytes - cytology Mitochondria - metabolism Precancerous Conditions T-Lymphocytes - pathology T-Lymphocytes - virology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - pathology Warburg effect, High-pressure gel chromatography |
| title | Cell-Mediated Immunity in Cervical Cancer Evolution |
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