Inhibition of Neutrophil Function by Two Tick Salivary Proteins

The saliva of hematophagous arthropods contains potent anti-inflammatory and antihemostatic activities that promote acquisition of the blood meal and enhance infection with pathogens. We have shown that polymorphonuclear leukocytes (PMN) treated with the saliva of the tick Ixodes scapularis have red...

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Veröffentlicht in:	Infection and Immunity 2009-06, Vol.77 (6), p.2320-2329
Hauptverfasser:	Guo, Xiuyang, Booth, Carmen J, Paley, Michael A, Wang, Xiaomei, DePonte, Kathleen, Fikrig, Erol, Narasimhan, Sukanya, Montgomery, Ruth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthropoda Biological and medical sciences Blood meals Borrelia burgdorferi Borrelia burgdorferi - isolation & purification Feeding Female Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Host Response and Inflammation Humans Infection Inflammation Integrins Integrins - antagonists & inhibitors Ixodes Ixodes - immunology Ixodes scapularis Ixodidae Joints Joints - microbiology Leukocytes (neutrophilic) Leukocytes (polymorphonuclear) Lyme disease Mice Microbiology Neutrophils - immunology Pathogens RNA-mediated interference Saliva Salivary gland Salivary Proteins and Peptides - genetics Salivary Proteins and Peptides - immunology Skin Skin - microbiology Spirochetes Superoxides - antagonists & inhibitors
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