Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors

M(2), M(3) and/or M(4) muscarinic acetylcholine receptors have been reported to mediate presynaptic inhibition in sympathetic neurons. M(1) receptors mediate an inhibition of K(v)7, Ca(V)1 and Ca(V)2.2 channels. These effects cause increases and decreases in transmitter release, respectively, but pr...

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Veröffentlicht in:	British journal of pharmacology 2009-04, Vol.156 (8), p.1342
Hauptverfasser:	Kubista, H, Kosenburger, K, Mahlknecht, P, Drobny, H, Boehm, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Action Potentials Adrenergic Fibers - drug effects Adrenergic Fibers - metabolism Animals Animals, Newborn Calcium Channel Blockers - pharmacology Calcium Channels - metabolism Calcium Signaling Carbamates - pharmacology Cells, Cultured Diamines - pharmacology Dose-Response Relationship, Drug Electric Stimulation KCNQ Potassium Channels - metabolism Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology Neural Inhibition - drug effects Norepinephrine - metabolism omega-Conotoxin GVIA - pharmacology Oxotremorine - pharmacology Pertussis Toxin - pharmacology Phenylenediamines - pharmacology Pirenzepine - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Rats Rats, Sprague-Dawley Receptor, Muscarinic M1 - drug effects Receptor, Muscarinic M1 - metabolism Receptors, Presynaptic - drug effects Receptors, Presynaptic - metabolism Superior Cervical Ganglion - cytology Superior Cervical Ganglion - drug effects Superior Cervical Ganglion - metabolism Synaptic Transmission - drug effects Time Factors Type C Phospholipases - metabolism
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