Crosstalk between adenosine receptor (A2A isoform) and ERalpha mediates ethanol action in MCF-7 breast cancer cells

Alcohol consumption increases the risk of breast cancer but the underlying mechanisms are not well understood. We have shown previously that ethanol activates ER signalling pathway in a cAMP/PKA-mediated ligand-independent manner. Since the activation of A2A adenosine receptor (A2AAR) by ethanol has...

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Veröffentlicht in:	Oncology reports 2009-04, Vol.21 (4), p.977
Hauptverfasser:	Etique, Nicolas, Grillier-Vuissoz, Isabelle, Lecomte, Julie, Flament, Stephane
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - etiology Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Line, Tumor Estrogen Receptor alpha - drug effects Estrogen Receptor alpha - physiology Ethanol - toxicity Female Humans Neoplasms, Hormone-Dependent - therapy Receptor Cross-Talk - physiology Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - physiology Signal Transduction - drug effects
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