Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts: role of PKCepsilon

Prenatal cocaine exposure in rats resulted in decreased PKCepsilon protein expression in the heart of adult male but not female offspring. The present study determined its functional consequence of inhibiting cardioprotection mediated by ischemic preconditioning. Pregnant Sprague-Dawley rats were ad...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2009-05, Vol.296 (5), p.H1566
Hauptverfasser:	Meyer, Kurt D, Zhang, Haitao, Zhang, Lubo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Cocaine - administration & dosage Coronary Circulation - drug effects Down-Regulation Female Gene Expression Regulation, Enzymologic - drug effects Gestational Age Injections, Intraperitoneal Ischemic Preconditioning, Myocardial Male Myocardial Infarction - enzymology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Phosphorylation Pregnancy Prenatal Exposure Delayed Effects Protein Kinase C-delta - metabolism Protein Kinase C-epsilon - antagonists & inhibitors Protein Kinase C-epsilon - genetics Protein Kinase C-epsilon - metabolism Protein Kinase Inhibitors - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Sex Factors Time Factors Ventricular Function, Left - drug effects
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