A cattle heart protein hydrolysate ameliorates hypercholesterolemia accompanied by suppression of the cholesterol absorption in rats and Caco-2 cells

The mechanism for the hypocholesterolemic action of a cattle heart protein hydrolysate (HPH) is clarified. The micellar solubility of cholesterol in vitro was significantly lower in the presence of HPH than in the presence of casein. The suppression of cholesterol uptake by Caco-2 cells was signific...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-03, Vol.73 (3), p.607-612
Hauptverfasser:	Nakade, K.(Itoham Foods Inc., Moriya, Ibaraki (Japan). Central Research Inst.), Kaneko, H, Oka, T, Ahhmed, A.M, Muguruma, M, Numata, M, Nagaoka, S
Format:	Artikel
Sprache:	eng
Schlagworte:	ABSORCION ABSORPTION Absorption - drug effects Animals Biological and medical sciences BLOOD SERUM BOVIN Caco-2 Cells Caseins - pharmacology CATTLE cattle heart CELLS CELLULE CELULAS CHOLESTEROL Cholesterol - metabolism COEUR COLESTEROL CORAZON Dietary Proteins - pharmacology Dietary Proteins - therapeutic use Fundamental and applied biological sciences. Psychology GANADO BOVINO HEART HIPERLIPIDEMIA Humans HYDROLYSAT DE PROTEINES HYDROLYZED PROTEINS Hypercholesterolemia - chemically induced Hypercholesterolemia - drug therapy Hypercholesterolemia - metabolism HYPERLIPIDAEMIA HYPERLIPIDEMIE INHIBICION INHIBITION livestock by-product Male Micelles Muscle Proteins - chemistry Muscle Proteins - pharmacology Muscle Proteins - therapeutic use Myocardium peptide Peptide Fragments - pharmacology Protein Hydrolysates - chemistry Protein Hydrolysates - pharmacology Protein Hydrolysates - therapeutic use PROTEINAS HIDROLIZADAS RAT RATA RATS SERUM SANGUIN Solubility SUERO SANGUINEO Ultrafiltration
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