Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability
We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (≤ 500 µM) did not inhibit chemotaxis on fibronectin in any cell line. However,...
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| Veröffentlicht in: | Cell adhesion & migration 2008-07, Vol.2 (3), p.153-160 |
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| container_title | Cell adhesion & migration |
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| creator | Bradke, Tiffany M Hall, Casey Carper, Stephen W Plopper, George E |
| description | We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (≤ 500 µM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 µM significantly inhibited cancer cell migration without effecting non-tumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at 8 days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells. |
| doi_str_mv | 10.4161/cam.2.3.6484 |
| format | Article |
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Treatment at 24 hours with BA (≤ 500 µM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 µM significantly inhibited cancer cell migration without effecting non-tumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at 8 days. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Binding Biology Bioscience Boric Acids - pharmacology Boronic Acids - pharmacology Breast Neoplasms - pathology Calcium Cancer Cell Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Cycle Fibronectins - metabolism Humans Landes Male Organogenesis Prostatic Neoplasms - pathology Proteins Short Communication Time Factors |
| title | Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability |
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