A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits"

NSC 676914 has been identified as a selective nuclear factor-kappaB (NF-kappaB) inhibitor that does not inhibit cell proliferation. This compound was originally identified in a high-throughput cell-based assay for activator protein-1 (AP-1) inhibitors using synthetic compound libraries and the Natio...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-03, Vol.8 (3), p.571
Hauptverfasser:	Kang, Moon-Il, Henrich, Curtis J, Bokesch, Heidi R, Gustafson, Kirk R, McMahon, James B, Baker, Alyson R, Young, Matthew R, Colburn, Nancy H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Azo Compounds - pharmacology Azo Compounds - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Proliferation - drug effects Cells, Cultured Drug Screening Assays, Antitumor Gene Expression Regulation, Neoplastic - drug effects Humans I-kappa B Proteins - metabolism Models, Biological NF-kappa B - antagonists & inhibitors NF-kappa B - genetics Phosphorylation - drug effects Small Molecule Libraries - analysis Substrate Specificity Sulfonic Acids - pharmacology Sulfonic Acids - therapeutic use Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - genetics Transfection
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