Detecting consciousness in a total locked-in syndrome: An active event-related paradigm
Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. In this study, consciousness was detected in a 21-year-old woman who presented a total locked-in syndrome after a basilar artery thrombosis (49 days post-injury) using an active event-related paradigm....
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| Veröffentlicht in: | Neurocase 2009-08, Vol.15 (4), p.271-277 |
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| creator | Schnakers, Caroline Perrin, Fabien Schabus, Manuel Hustinx, Roland Majerus, Steve Moonen, Gustave Boly, Melanie Vanhaudenhuyse, Audrey Bruno, Marie-Aurelie Laureys, Steven |
| description | Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. In this study, consciousness was detected in a 21-year-old woman who presented a total locked-in syndrome after a basilar artery thrombosis (49 days post-injury) using an active event-related paradigm. The patient was presented sequences of names containing the patient's own name and other names. The patient was instructed to count her own name or to count another target name. Similar to 4 age- and gender-matched healthy controls, the P3 response recorded for the voluntarily counted own name was larger than while passively listening. This P3 response was observed 14 days before the first behavioral signs of consciousness. This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose. |
| doi_str_mv | 10.1080/13554790902724904 |
| format | Article |
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In this study, consciousness was detected in a 21-year-old woman who presented a total locked-in syndrome after a basilar artery thrombosis (49 days post-injury) using an active event-related paradigm. The patient was presented sequences of names containing the patient's own name and other names. The patient was instructed to count her own name or to count another target name. Similar to 4 age- and gender-matched healthy controls, the P3 response recorded for the voluntarily counted own name was larger than while passively listening. This P3 response was observed 14 days before the first behavioral signs of consciousness. This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose.</description><identifier>ISSN: 1355-4794</identifier><identifier>ISSN: 1465-3656</identifier><identifier>EISSN: 1465-3656</identifier><identifier>DOI: 10.1080/13554790902724904</identifier><identifier>PMID: 19241281</identifier><language>eng</language><publisher>England: Taylor & Francis Group</publisher><subject>Brain - diagnostic imaging ; Brain - pathology ; Brain - physiopathology ; Brain injury ; Coma - diagnosis ; Coma - etiology ; Consciousness ; Consciousness - physiology ; Disability Evaluation ; Electroencephalography - methods ; Event-Related Potentials, P300 - physiology ; Evoked potentials ; Female ; Human health sciences ; Humans ; Locked-in syndrome ; Magnetic Resonance Imaging ; Neurologie ; Neurology ; Neuropsychological Tests ; Positron-Emission Tomography ; Predictive Value of Tests ; Prognosis ; Quadriplegia - complications ; Quadriplegia - pathology ; Quadriplegia - physiopathology ; Recovery of Function - physiology ; Sciences de la santé humaine ; Sensitivity and Specificity ; Tetraplegia ; Vertebrobasilar Insufficiency - complications ; Volition - physiology ; Young Adult</subject><ispartof>Neurocase, 2009-08, Vol.15 (4), p.271-277</ispartof><rights>Copyright 2009 Psychology Press, an imprint of the Taylor & Francis Group, an Informa business 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-3bed89d98bdd62ca15c0fc85e86c5d3f7e34f49de583b325d08c3d137d1feda63</citedby><cites>FETCH-LOGICAL-c585t-3bed89d98bdd62ca15c0fc85e86c5d3f7e34f49de583b325d08c3d137d1feda63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13554790902724904$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13554790902724904$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19241281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schnakers, Caroline</creatorcontrib><creatorcontrib>Perrin, Fabien</creatorcontrib><creatorcontrib>Schabus, Manuel</creatorcontrib><creatorcontrib>Hustinx, Roland</creatorcontrib><creatorcontrib>Majerus, Steve</creatorcontrib><creatorcontrib>Moonen, Gustave</creatorcontrib><creatorcontrib>Boly, Melanie</creatorcontrib><creatorcontrib>Vanhaudenhuyse, Audrey</creatorcontrib><creatorcontrib>Bruno, Marie-Aurelie</creatorcontrib><creatorcontrib>Laureys, Steven</creatorcontrib><title>Detecting consciousness in a total locked-in syndrome: An active event-related paradigm</title><title>Neurocase</title><addtitle>Neurocase</addtitle><description>Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. In this study, consciousness was detected in a 21-year-old woman who presented a total locked-in syndrome after a basilar artery thrombosis (49 days post-injury) using an active event-related paradigm. The patient was presented sequences of names containing the patient's own name and other names. The patient was instructed to count her own name or to count another target name. Similar to 4 age- and gender-matched healthy controls, the P3 response recorded for the voluntarily counted own name was larger than while passively listening. This P3 response was observed 14 days before the first behavioral signs of consciousness. 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Perrin, Fabien ; Schabus, Manuel ; Hustinx, Roland ; Majerus, Steve ; Moonen, Gustave ; Boly, Melanie ; Vanhaudenhuyse, Audrey ; Bruno, Marie-Aurelie ; Laureys, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-3bed89d98bdd62ca15c0fc85e86c5d3f7e34f49de583b325d08c3d137d1feda63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain injury</topic><topic>Coma - diagnosis</topic><topic>Coma - etiology</topic><topic>Consciousness</topic><topic>Consciousness - physiology</topic><topic>Disability Evaluation</topic><topic>Electroencephalography - methods</topic><topic>Event-Related Potentials, P300 - physiology</topic><topic>Evoked potentials</topic><topic>Female</topic><topic>Human health sciences</topic><topic>Humans</topic><topic>Locked-in syndrome</topic><topic>Magnetic Resonance Imaging</topic><topic>Neurologie</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Quadriplegia - complications</topic><topic>Quadriplegia - pathology</topic><topic>Quadriplegia - physiopathology</topic><topic>Recovery of Function - physiology</topic><topic>Sciences de la santé humaine</topic><topic>Sensitivity and Specificity</topic><topic>Tetraplegia</topic><topic>Vertebrobasilar Insufficiency - complications</topic><topic>Volition - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnakers, Caroline</creatorcontrib><creatorcontrib>Perrin, Fabien</creatorcontrib><creatorcontrib>Schabus, Manuel</creatorcontrib><creatorcontrib>Hustinx, Roland</creatorcontrib><creatorcontrib>Majerus, Steve</creatorcontrib><creatorcontrib>Moonen, Gustave</creatorcontrib><creatorcontrib>Boly, Melanie</creatorcontrib><creatorcontrib>Vanhaudenhuyse, Audrey</creatorcontrib><creatorcontrib>Bruno, Marie-Aurelie</creatorcontrib><creatorcontrib>Laureys, Steven</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><jtitle>Neurocase</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnakers, Caroline</au><au>Perrin, Fabien</au><au>Schabus, Manuel</au><au>Hustinx, Roland</au><au>Majerus, Steve</au><au>Moonen, Gustave</au><au>Boly, Melanie</au><au>Vanhaudenhuyse, Audrey</au><au>Bruno, Marie-Aurelie</au><au>Laureys, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detecting consciousness in a total locked-in syndrome: An active event-related paradigm</atitle><jtitle>Neurocase</jtitle><addtitle>Neurocase</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>15</volume><issue>4</issue><spage>271</spage><epage>277</epage><pages>271-277</pages><issn>1355-4794</issn><issn>1465-3656</issn><eissn>1465-3656</eissn><abstract>Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. 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| subjects | Brain - diagnostic imaging Brain - pathology Brain - physiopathology Brain injury Coma - diagnosis Coma - etiology Consciousness Consciousness - physiology Disability Evaluation Electroencephalography - methods Event-Related Potentials, P300 - physiology Evoked potentials Female Human health sciences Humans Locked-in syndrome Magnetic Resonance Imaging Neurologie Neurology Neuropsychological Tests Positron-Emission Tomography Predictive Value of Tests Prognosis Quadriplegia - complications Quadriplegia - pathology Quadriplegia - physiopathology Recovery of Function - physiology Sciences de la santé humaine Sensitivity and Specificity Tetraplegia Vertebrobasilar Insufficiency - complications Volition - physiology Young Adult |
| title | Detecting consciousness in a total locked-in syndrome: An active event-related paradigm |
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