Improved cartilage regeneration utilizing mesenchymal stem cells in TGF-beta1 gene-activated scaffolds

Recently, bone marrow-derived mesenchymal stem cells (MSCs) have been paid more attention for cartilage regeneration. This study evaluated the potential of using MSCs seeded in plasmid transforming growth factor beta1 (pTGF-beta1)-activated three-dimensional chitosan/gelatin scaffolds for improving...

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Veröffentlicht in:	Tissue engineering. Part A 2009-09, Vol.15 (9), p.2687
Hauptverfasser:	Diao, Huajia, Wang, Jinliang, Shen, Chao, Xia, Suhua, Guo, Ting, Dong, Lei, Zhang, Chenyu, Chen, Jiangning, Zhao, Jianning, Zhang, Junfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage - drug effects Cartilage - physiology Cartilage, Articular - drug effects Cartilage, Articular - pathology Cattle Cell Proliferation - drug effects Chitosan - pharmacology Collagen Type II - metabolism Enzyme-Linked Immunosorbent Assay Gelatin - pharmacology Gene Expression Regulation - drug effects Green Fluorescent Proteins - metabolism Hyaline Cartilage - drug effects Hyaline Cartilage - metabolism Hyaline Cartilage - pathology Immunohistochemistry Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - ultrastructure Organ Specificity - drug effects Organ Specificity - genetics Rabbits Regeneration - drug effects Regeneration - physiology Tissue Scaffolds - chemistry Transforming Growth Factor beta1 - genetics Wound Healing - drug effects
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