Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus

The histone H3 demethylase Not dead yet-1 (Ndy1/KDM2B) is a physiological inhibitor of senescence. Here, we show that Ndy1 is down-regulated during senescence in mouse embryonic fibroblasts (MEFs) and that it represses the Ink4a/Arf locus. Ndy1 counteracts the senescence-associated down-regulation o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (8), p.2641-2646
Hauptverfasser:	Tzatsos, Alexandros, Pfau, Raymond, Kampranis, Sotirios C, Tsichlis, Philip N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Line, Transformed Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 - genetics cyclin-dependent kinase inhibitors DNA-directed RNA polymerase Down regulation Embryo fibroblasts Enhancer of Zeste Homolog 2 Protein Fibroblasts - cytology Gene expression regulation Gene Expression Regulation, Developmental - physiology Gene silencing Genetic loci Histone H3 Histone-Lysine N-Methyltransferase - physiology Histones Histones - metabolism Immortalization INK4 protein Messenger RNA Methylation Mice Molecular modelling Nuclear Proteins - physiology Oxidoreductases, N-Demethylating - physiology Polycomb Repressive Complex 1 Polycomb Repressive Complex 2 Proto-Oncogene Proteins - physiology Ras protein Repressor Proteins - physiology RNA Senescence Stem cells Up regulation
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