Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
R. H. LaMotte, C. N. Shain, D. A. Simone and E. F. Tsai Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510. 1. Psychophysical studies were made, in humans, of the sensory characteristics and underlying mechanisms of the hyperalgesia (often termed "sec...
Gespeichert in:
| Veröffentlicht in: | Journal of neurophysiology 1991-07, Vol.66 (1), p.190-211 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 211 |
|---|---|
| container_issue | 1 |
| container_start_page | 190 |
| container_title | Journal of neurophysiology |
| container_volume | 66 |
| creator | LaMotte, R. H Shain, C. N Simone, D. A Tsai, E. F |
| description | R. H. LaMotte, C. N. Shain, D. A. Simone and E. F. Tsai
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.
1. Psychophysical studies were made, in humans, of the sensory
characteristics and underlying mechanisms of the hyperalgesia (often termed
"secondary hyperalgesia") that occurs in uninjured skin surrounding a local
cutaneous injury. The hyperalgesia was characterized by lowered pain
thresholds and enhanced magnitude of pain to normally painful stimuli. The
"injury" was produced by a single intradermal injection of 10 microliters
of 100 micrograms of capsaicin, the algesic substance in hot chili peppers.
2. On injection of capsaicin into the volar forearm, the subjects
experienced intense burning pain, accompanied immediately by the formation
of three areas of hyperalgesia surrounding the injection site. The largest
mean area (55 cm2) was hyperalgesic to a normally painful punctate
stimulation of the skin. Nested within this was an area of tenderness to
gentle stroking (38 cm2) and a much smaller area of hyperalgesia to heat (2
cm2). An area of analgesia to pinprick, approximately 4 mm in diameter and
centered on the injection site, developed within minutes and typically
disappeared within 24 h. The hyperalgesia to heat and to stroking
disappeared within 1-2 h, whereas the hyperalgesia to punctate stimuli,
although gradually decreasing in area, lasted from 13 to 24 h. 3. The
radial spread of the mechanical hyperalgesia (to punctate and stroking
stimuli) away from the injury was dependent on neural activity and not
produced, for example, by algesic substances transported away from the
injury. The injection of capsaicin into a small area of anesthetized skin
did not produce hyperalgesia in the surrounding, unanesthetized skin. Also,
the hyperalgesia in normal skin readily crossed a tight arm band that
blocked the circulation of blood and lymph. 4. The spread of mechanical
hyperalgesia away from the injury was peripherally mediated via cutaneous
nerve fibers because it was blocked by a thin mediolateral strip of
cutaneous anesthesia placed 1 cm away from the capsaicin injection site.
Hyperalgesia developed normally on the capsaicin side of the strip but not
on the other side. 5. Heat stimulation of the skin that produced pain that
was equivalent in magnitude and time course to that produced by an
injection of capsaicin (10 micrograms) resulted in much smaller areas of
mechanical hyperalgesia. It was postulated |
| doi_str_mv | 10.1152/jn.1991.66.1.190 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_highw</sourceid><recordid>TN_cdi_pubmed_primary_1919666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1919666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-f70f97e80172b1ca8a01da7751a48b48769431b9177a3b437d73c566a06744c63</originalsourceid><addsrcrecordid>eNpFUMtOwzAQtBColMKdC1IOiFvCbuLYMTdUAUWq4ALnyHGcxFVeshuh_D0pqcppRzszO9oh5BYhQIzDx10boBAYMBbghOCMLKd16GMsknOyBJhwBJxfkivndgDAYwgXZIECBWNsSTYferBdqVujvGrstZV1qZ2RT17vRlV1fTU6o2Ttuf2QG-28rvCGNte2Hk1beo1WlWyNa9w1uShk7fTNca7I9-vL13rjbz_f3tfPW19RGu_9gkMhuE4AeZihkokEzCXnMUqaZDThTNAIM4GcyyijEc95pGLGJDBOqWLRisB8V9nOOauLtLemkXZMEdJDJ-muTQ-dpIylOCGYLHezpR-yRuf_hrmEib8_8tJNrxZWtsq4k4wKyhH4JHuYZZUpqx9jdfpXTld35XgIPeX9AtSVd30</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>LaMotte, R. H ; Shain, C. N ; Simone, D. A ; Tsai, E. F</creator><creatorcontrib>LaMotte, R. H ; Shain, C. N ; Simone, D. A ; Tsai, E. F</creatorcontrib><description>R. H. LaMotte, C. N. Shain, D. A. Simone and E. F. Tsai
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.
1. Psychophysical studies were made, in humans, of the sensory
characteristics and underlying mechanisms of the hyperalgesia (often termed
"secondary hyperalgesia") that occurs in uninjured skin surrounding a local
cutaneous injury. The hyperalgesia was characterized by lowered pain
thresholds and enhanced magnitude of pain to normally painful stimuli. The
"injury" was produced by a single intradermal injection of 10 microliters
of 100 micrograms of capsaicin, the algesic substance in hot chili peppers.
2. On injection of capsaicin into the volar forearm, the subjects
experienced intense burning pain, accompanied immediately by the formation
of three areas of hyperalgesia surrounding the injection site. The largest
mean area (55 cm2) was hyperalgesic to a normally painful punctate
stimulation of the skin. Nested within this was an area of tenderness to
gentle stroking (38 cm2) and a much smaller area of hyperalgesia to heat (2
cm2). An area of analgesia to pinprick, approximately 4 mm in diameter and
centered on the injection site, developed within minutes and typically
disappeared within 24 h. The hyperalgesia to heat and to stroking
disappeared within 1-2 h, whereas the hyperalgesia to punctate stimuli,
although gradually decreasing in area, lasted from 13 to 24 h. 3. The
radial spread of the mechanical hyperalgesia (to punctate and stroking
stimuli) away from the injury was dependent on neural activity and not
produced, for example, by algesic substances transported away from the
injury. The injection of capsaicin into a small area of anesthetized skin
did not produce hyperalgesia in the surrounding, unanesthetized skin. Also,
the hyperalgesia in normal skin readily crossed a tight arm band that
blocked the circulation of blood and lymph. 4. The spread of mechanical
hyperalgesia away from the injury was peripherally mediated via cutaneous
nerve fibers because it was blocked by a thin mediolateral strip of
cutaneous anesthesia placed 1 cm away from the capsaicin injection site.
Hyperalgesia developed normally on the capsaicin side of the strip but not
on the other side. 5. Heat stimulation of the skin that produced pain that
was equivalent in magnitude and time course to that produced by an
injection of capsaicin (10 micrograms) resulted in much smaller areas of
mechanical hyperalgesia. It was postulated that there exist special
chemosensitive primary afferent nerve fibers that are more effective in
producing mechanical hyperalgesia than are the known thermo- and
mechanosensitive nociceptive nerve fibers. 6. Once developed, the
mechanical hyperalgesia became only partially dependent on peripheral
neural activity originating at the site of injury.</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.1991.66.1.190</identifier><identifier>PMID: 1919666</identifier><identifier>CODEN: JONEA4</identifier><language>eng</language><publisher>Bethesda, MD: Am Phys Soc</publisher><subject>Adult ; Aged ; Anesthesia, Local ; Biological and medical sciences ; Capsaicin ; Central Nervous System - cytology ; Central Nervous System - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hyperalgesia - chemically induced ; Hyperalgesia - etiology ; Hyperalgesia - physiopathology ; Lymph - physiology ; Male ; Middle Aged ; Nerve Fibers - physiology ; Nervous System Physiological Phenomena ; Neurons - physiology ; Pain - chemically induced ; Peripheral Nerves - cytology ; Peripheral Nerves - physiology ; Physical Stimulation - methods ; Psychophysics ; Regional Blood Flow ; Skin - blood supply ; Skin - drug effects ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurophysiology, 1991-07, Vol.66 (1), p.190-211</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-f70f97e80172b1ca8a01da7751a48b48769431b9177a3b437d73c566a06744c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4947107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1919666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LaMotte, R. H</creatorcontrib><creatorcontrib>Shain, C. N</creatorcontrib><creatorcontrib>Simone, D. A</creatorcontrib><creatorcontrib>Tsai, E. F</creatorcontrib><title>Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>R. H. LaMotte, C. N. Shain, D. A. Simone and E. F. Tsai
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.
1. Psychophysical studies were made, in humans, of the sensory
characteristics and underlying mechanisms of the hyperalgesia (often termed
"secondary hyperalgesia") that occurs in uninjured skin surrounding a local
cutaneous injury. The hyperalgesia was characterized by lowered pain
thresholds and enhanced magnitude of pain to normally painful stimuli. The
"injury" was produced by a single intradermal injection of 10 microliters
of 100 micrograms of capsaicin, the algesic substance in hot chili peppers.
2. On injection of capsaicin into the volar forearm, the subjects
experienced intense burning pain, accompanied immediately by the formation
of three areas of hyperalgesia surrounding the injection site. The largest
mean area (55 cm2) was hyperalgesic to a normally painful punctate
stimulation of the skin. Nested within this was an area of tenderness to
gentle stroking (38 cm2) and a much smaller area of hyperalgesia to heat (2
cm2). An area of analgesia to pinprick, approximately 4 mm in diameter and
centered on the injection site, developed within minutes and typically
disappeared within 24 h. The hyperalgesia to heat and to stroking
disappeared within 1-2 h, whereas the hyperalgesia to punctate stimuli,
although gradually decreasing in area, lasted from 13 to 24 h. 3. The
radial spread of the mechanical hyperalgesia (to punctate and stroking
stimuli) away from the injury was dependent on neural activity and not
produced, for example, by algesic substances transported away from the
injury. The injection of capsaicin into a small area of anesthetized skin
did not produce hyperalgesia in the surrounding, unanesthetized skin. Also,
the hyperalgesia in normal skin readily crossed a tight arm band that
blocked the circulation of blood and lymph. 4. The spread of mechanical
hyperalgesia away from the injury was peripherally mediated via cutaneous
nerve fibers because it was blocked by a thin mediolateral strip of
cutaneous anesthesia placed 1 cm away from the capsaicin injection site.
Hyperalgesia developed normally on the capsaicin side of the strip but not
on the other side. 5. Heat stimulation of the skin that produced pain that
was equivalent in magnitude and time course to that produced by an
injection of capsaicin (10 micrograms) resulted in much smaller areas of
mechanical hyperalgesia. It was postulated that there exist special
chemosensitive primary afferent nerve fibers that are more effective in
producing mechanical hyperalgesia than are the known thermo- and
mechanosensitive nociceptive nerve fibers. 6. Once developed, the
mechanical hyperalgesia became only partially dependent on peripheral
neural activity originating at the site of injury.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia, Local</subject><subject>Biological and medical sciences</subject><subject>Capsaicin</subject><subject>Central Nervous System - cytology</subject><subject>Central Nervous System - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hyperalgesia - chemically induced</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Lymph - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Fibers - physiology</subject><subject>Nervous System Physiological Phenomena</subject><subject>Neurons - physiology</subject><subject>Pain - chemically induced</subject><subject>Peripheral Nerves - cytology</subject><subject>Peripheral Nerves - physiology</subject><subject>Physical Stimulation - methods</subject><subject>Psychophysics</subject><subject>Regional Blood Flow</subject><subject>Skin - blood supply</subject><subject>Skin - drug effects</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUMtOwzAQtBColMKdC1IOiFvCbuLYMTdUAUWq4ALnyHGcxFVeshuh_D0pqcppRzszO9oh5BYhQIzDx10boBAYMBbghOCMLKd16GMsknOyBJhwBJxfkivndgDAYwgXZIECBWNsSTYferBdqVujvGrstZV1qZ2RT17vRlV1fTU6o2Ttuf2QG-28rvCGNte2Hk1beo1WlWyNa9w1uShk7fTNca7I9-vL13rjbz_f3tfPW19RGu_9gkMhuE4AeZihkokEzCXnMUqaZDThTNAIM4GcyyijEc95pGLGJDBOqWLRisB8V9nOOauLtLemkXZMEdJDJ-muTQ-dpIylOCGYLHezpR-yRuf_hrmEib8_8tJNrxZWtsq4k4wKyhH4JHuYZZUpqx9jdfpXTld35XgIPeX9AtSVd30</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>LaMotte, R. H</creator><creator>Shain, C. N</creator><creator>Simone, D. A</creator><creator>Tsai, E. F</creator><general>Am Phys Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19910701</creationdate><title>Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms</title><author>LaMotte, R. H ; Shain, C. N ; Simone, D. A ; Tsai, E. F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-f70f97e80172b1ca8a01da7751a48b48769431b9177a3b437d73c566a06744c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia, Local</topic><topic>Biological and medical sciences</topic><topic>Capsaicin</topic><topic>Central Nervous System - cytology</topic><topic>Central Nervous System - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hyperalgesia - chemically induced</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Lymph - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Fibers - physiology</topic><topic>Nervous System Physiological Phenomena</topic><topic>Neurons - physiology</topic><topic>Pain - chemically induced</topic><topic>Peripheral Nerves - cytology</topic><topic>Peripheral Nerves - physiology</topic><topic>Physical Stimulation - methods</topic><topic>Psychophysics</topic><topic>Regional Blood Flow</topic><topic>Skin - blood supply</topic><topic>Skin - drug effects</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LaMotte, R. H</creatorcontrib><creatorcontrib>Shain, C. N</creatorcontrib><creatorcontrib>Simone, D. A</creatorcontrib><creatorcontrib>Tsai, E. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LaMotte, R. H</au><au>Shain, C. N</au><au>Simone, D. A</au><au>Tsai, E. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>66</volume><issue>1</issue><spage>190</spage><epage>211</epage><pages>190-211</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><coden>JONEA4</coden><abstract>R. H. LaMotte, C. N. Shain, D. A. Simone and E. F. Tsai
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.
1. Psychophysical studies were made, in humans, of the sensory
characteristics and underlying mechanisms of the hyperalgesia (often termed
"secondary hyperalgesia") that occurs in uninjured skin surrounding a local
cutaneous injury. The hyperalgesia was characterized by lowered pain
thresholds and enhanced magnitude of pain to normally painful stimuli. The
"injury" was produced by a single intradermal injection of 10 microliters
of 100 micrograms of capsaicin, the algesic substance in hot chili peppers.
2. On injection of capsaicin into the volar forearm, the subjects
experienced intense burning pain, accompanied immediately by the formation
of three areas of hyperalgesia surrounding the injection site. The largest
mean area (55 cm2) was hyperalgesic to a normally painful punctate
stimulation of the skin. Nested within this was an area of tenderness to
gentle stroking (38 cm2) and a much smaller area of hyperalgesia to heat (2
cm2). An area of analgesia to pinprick, approximately 4 mm in diameter and
centered on the injection site, developed within minutes and typically
disappeared within 24 h. The hyperalgesia to heat and to stroking
disappeared within 1-2 h, whereas the hyperalgesia to punctate stimuli,
although gradually decreasing in area, lasted from 13 to 24 h. 3. The
radial spread of the mechanical hyperalgesia (to punctate and stroking
stimuli) away from the injury was dependent on neural activity and not
produced, for example, by algesic substances transported away from the
injury. The injection of capsaicin into a small area of anesthetized skin
did not produce hyperalgesia in the surrounding, unanesthetized skin. Also,
the hyperalgesia in normal skin readily crossed a tight arm band that
blocked the circulation of blood and lymph. 4. The spread of mechanical
hyperalgesia away from the injury was peripherally mediated via cutaneous
nerve fibers because it was blocked by a thin mediolateral strip of
cutaneous anesthesia placed 1 cm away from the capsaicin injection site.
Hyperalgesia developed normally on the capsaicin side of the strip but not
on the other side. 5. Heat stimulation of the skin that produced pain that
was equivalent in magnitude and time course to that produced by an
injection of capsaicin (10 micrograms) resulted in much smaller areas of
mechanical hyperalgesia. It was postulated that there exist special
chemosensitive primary afferent nerve fibers that are more effective in
producing mechanical hyperalgesia than are the known thermo- and
mechanosensitive nociceptive nerve fibers. 6. Once developed, the
mechanical hyperalgesia became only partially dependent on peripheral
neural activity originating at the site of injury.</abstract><cop>Bethesda, MD</cop><pub>Am Phys Soc</pub><pmid>1919666</pmid><doi>10.1152/jn.1991.66.1.190</doi><tpages>22</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3077 |
| ispartof | Journal of neurophysiology, 1991-07, Vol.66 (1), p.190-211 |
| issn | 0022-3077 1522-1598 |
| language | eng |
| recordid | cdi_pubmed_primary_1919666 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Anesthesia, Local Biological and medical sciences Capsaicin Central Nervous System - cytology Central Nervous System - physiology Female Fundamental and applied biological sciences. Psychology Humans Hyperalgesia - chemically induced Hyperalgesia - etiology Hyperalgesia - physiopathology Lymph - physiology Male Middle Aged Nerve Fibers - physiology Nervous System Physiological Phenomena Neurons - physiology Pain - chemically induced Peripheral Nerves - cytology Peripheral Nerves - physiology Physical Stimulation - methods Psychophysics Regional Blood Flow Skin - blood supply Skin - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T21%3A48%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurogenic%20hyperalgesia:%20psychophysical%20studies%20of%20underlying%20mechanisms&rft.jtitle=Journal%20of%20neurophysiology&rft.au=LaMotte,%20R.%20H&rft.date=1991-07-01&rft.volume=66&rft.issue=1&rft.spage=190&rft.epage=211&rft.pages=190-211&rft.issn=0022-3077&rft.eissn=1522-1598&rft.coden=JONEA4&rft_id=info:doi/10.1152/jn.1991.66.1.190&rft_dat=%3Cpubmed_highw%3E1919666%3C/pubmed_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/1919666&rfr_iscdi=true |