Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site

The heterotrimeric influenza virus polymerase, containing the PA, PB1 and PB2 proteins, catalyses viral RNA replication and transcription in the nucleus of infected cells. PB1 holds the polymerase active site and reportedly harbours endonuclease activity, whereas PB2 is responsible for cap binding....

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Veröffentlicht in:	Nature 2009-04, Vol.458 (7240), p.909
Hauptverfasser:	Yuan, Puwei, Bartlam, Mark, Lou, Zhiyong, Chen, Shoudeng, Zhou, Jie, He, Xiaojing, Lv, Zongyang, Ge, Ruowen, Li, Xuemei, Deng, Tao, Fodor, Ervin, Rao, Zihe, Liu, Yingfang
Format:	Artikel
Sprache:	eng
Schlagworte:	AMINO ACIDS Animals ARCHITECTURE Birds - virology Catalytic Domain CRYSTAL STRUCTURE Crystallography, X-Ray DESIGN ENDONUCLEASES Endonucleases - chemistry Endonucleases - genetics Endonucleases - metabolism FUNCTIONAL ANALYSIS FUNCTIONALS IN VITRO IN VIVO INFLUENZA Influenza A Virus, H5N1 Subtype - enzymology Influenza in Birds - virology MAGNESIUM IONS MATERIALS SCIENCE Models, Molecular MUTAGENESIS POLYMERASES PROMOTERS Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism PROTEINS RESIDUES RNA RNA Replicase - chemistry RNA Replicase - genetics RNA Replicase - metabolism STRAINS TRANSCRIPTION Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism
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