Effects of Neonatal Administration of Diethylstilbestrol on Aberrant Crypt Foci Induced by 7,12-Dimethylbenz[α]anthracene in Rats
Gastrointestinal carcinoma is affected environmental factors, however, it remains to be determined whether neonatal administration of an estrogenic endocrine disruptor, such as diethylstilbestrol (DES), affects gastrointestinal carcinogenesis. The effects of neonatally administered DES on gastrointe...
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| Veröffentlicht in: | In vivo (Athens) 2008-11, Vol.22 (6), p.699 |
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| creator | Kawashima, Hideo Kawaguchi, Hiroaki Umekita, Yoshihisa Souda, Masakazu Gejima, Kentaro Komokata, Teruo Sakata, Ryuzo Yoshida, Hiroki |
| description | Gastrointestinal carcinoma is affected environmental factors, however, it remains to be determined whether neonatal administration
of an estrogenic endocrine disruptor, such as diethylstilbestrol (DES), affects gastrointestinal carcinogenesis. The effects
of neonatally administered DES on gastrointestinal tumorigenesis induced by 7,12-dimethylbenz[α]anthracene (DMBA) were investigated
in male and female rats. Male and female rats in group I were daily administered oil alone from 0-14 days after birth. Male
and female rats in groups II and III were daily administered DES at 1 and 10 μg/rat, respectively. The administration periods
of DES in subgroups a (IIa and IIIa), b (IIb and IIIb) and c (IIc and IIIc) were from 0-14, 0-5 and 6-14 days after birth,
respectively. At 28, 42 and 56 days after birth, all male rats were given 10 mg of DMBA. At 50 days after birth, all female
rats were given 10 mg of DMBA. In the digestive tracts of male rats, forestomach masses (FMs) in all groups (13-58%), small
intestine masses in group IIIa (17%), and colon masses (CMs) in groups IIIa (8%) and IIIb (33%) were observed, although there
were no significant changes in the incidence and number. In the digestive tracts of female rats, FMs in groups I (10%), IIa
(13%), IIb (33%), IIc (25%) and IIIc (33%), CMs in groups IIa (6%) and IIIa (6%) were seen, although there were no significant
changes in the incidence. Aberrant crypt foci (ACF) in the colon and rectum were seen in all male and female rats. The neonatal
administration of DES in male rats increased the number of ACF while that in female rats did not. These results suggest that
neonatal administration of DES may affect male colorectal carcinogenesis. |
| format | Article |
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of an estrogenic endocrine disruptor, such as diethylstilbestrol (DES), affects gastrointestinal carcinogenesis. The effects
of neonatally administered DES on gastrointestinal tumorigenesis induced by 7,12-dimethylbenz[α]anthracene (DMBA) were investigated
in male and female rats. Male and female rats in group I were daily administered oil alone from 0-14 days after birth. Male
and female rats in groups II and III were daily administered DES at 1 and 10 μg/rat, respectively. The administration periods
of DES in subgroups a (IIa and IIIa), b (IIb and IIIb) and c (IIc and IIIc) were from 0-14, 0-5 and 6-14 days after birth,
respectively. At 28, 42 and 56 days after birth, all male rats were given 10 mg of DMBA. At 50 days after birth, all female
rats were given 10 mg of DMBA. In the digestive tracts of male rats, forestomach masses (FMs) in all groups (13-58%), small
intestine masses in group IIIa (17%), and colon masses (CMs) in groups IIIa (8%) and IIIb (33%) were observed, although there
were no significant changes in the incidence and number. In the digestive tracts of female rats, FMs in groups I (10%), IIa
(13%), IIb (33%), IIc (25%) and IIIc (33%), CMs in groups IIa (6%) and IIIa (6%) were seen, although there were no significant
changes in the incidence. Aberrant crypt foci (ACF) in the colon and rectum were seen in all male and female rats. The neonatal
administration of DES in male rats increased the number of ACF while that in female rats did not. These results suggest that
neonatal administration of DES may affect male colorectal carcinogenesis.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 19180994</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage ; 9,10-Dimethyl-1,2-benzanthracene - toxicity ; Animals ; Animals, Newborn ; Atrophy ; Carcinogens - administration & dosage ; Carcinogens - toxicity ; Colon - drug effects ; Colon - pathology ; Diethylstilbestrol - pharmacology ; Dose-Response Relationship, Drug ; Female ; Gastrointestinal Neoplasms - chemically induced ; Gastrointestinal Neoplasms - pathology ; Intubation, Gastrointestinal ; Male ; Rats ; Rats, Sprague-Dawley ; Rectum - drug effects ; Rectum - pathology ; Sperm Count ; Testis - abnormalities ; Testis - drug effects ; Testis - pathology ; Weaning</subject><ispartof>In vivo (Athens), 2008-11, Vol.22 (6), p.699</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19180994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawashima, Hideo</creatorcontrib><creatorcontrib>Kawaguchi, Hiroaki</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>Souda, Masakazu</creatorcontrib><creatorcontrib>Gejima, Kentaro</creatorcontrib><creatorcontrib>Komokata, Teruo</creatorcontrib><creatorcontrib>Sakata, Ryuzo</creatorcontrib><creatorcontrib>Yoshida, Hiroki</creatorcontrib><title>Effects of Neonatal Administration of Diethylstilbestrol on Aberrant Crypt Foci Induced by 7,12-Dimethylbenz[α]anthracene in Rats</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Gastrointestinal carcinoma is affected environmental factors, however, it remains to be determined whether neonatal administration
of an estrogenic endocrine disruptor, such as diethylstilbestrol (DES), affects gastrointestinal carcinogenesis. The effects
of neonatally administered DES on gastrointestinal tumorigenesis induced by 7,12-dimethylbenz[α]anthracene (DMBA) were investigated
in male and female rats. Male and female rats in group I were daily administered oil alone from 0-14 days after birth. Male
and female rats in groups II and III were daily administered DES at 1 and 10 μg/rat, respectively. The administration periods
of DES in subgroups a (IIa and IIIa), b (IIb and IIIb) and c (IIc and IIIc) were from 0-14, 0-5 and 6-14 days after birth,
respectively. At 28, 42 and 56 days after birth, all male rats were given 10 mg of DMBA. At 50 days after birth, all female
rats were given 10 mg of DMBA. In the digestive tracts of male rats, forestomach masses (FMs) in all groups (13-58%), small
intestine masses in group IIIa (17%), and colon masses (CMs) in groups IIIa (8%) and IIIb (33%) were observed, although there
were no significant changes in the incidence and number. In the digestive tracts of female rats, FMs in groups I (10%), IIa
(13%), IIb (33%), IIc (25%) and IIIc (33%), CMs in groups IIa (6%) and IIIa (6%) were seen, although there were no significant
changes in the incidence. Aberrant crypt foci (ACF) in the colon and rectum were seen in all male and female rats. The neonatal
administration of DES in male rats increased the number of ACF while that in female rats did not. These results suggest that
neonatal administration of DES may affect male colorectal carcinogenesis.</description><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</subject><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Atrophy</subject><subject>Carcinogens - administration & dosage</subject><subject>Carcinogens - toxicity</subject><subject>Colon - drug effects</subject><subject>Colon - pathology</subject><subject>Diethylstilbestrol - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - chemically induced</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>Intubation, Gastrointestinal</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rectum - drug effects</subject><subject>Rectum - pathology</subject><subject>Sperm Count</subject><subject>Testis - abnormalities</subject><subject>Testis - drug effects</subject><subject>Testis - pathology</subject><subject>Weaning</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtKxDAARYMozjj6C5KFSwt5TPNYDvPQgUFBFASRkjapjbTpkGRG6tq1_-Iv6I9ZHV3dxTn3Lu4eGGIuccLTsdwHQ0RSkYgU3w_AUQjPCDGOEDkEAyyxQFKOh-BtXpamiAG2JbwyrVNR1XCiG-tsiF5F27ofNLMmVl0doq1z04O2hj2Y5MZ75SKc-m4d4aItLFw6vSmMhnkH-Tkmycw2v9XcuNeHr_fPj8e-UHlVGGegdfBGxXAMDkpVB3PylyNwt5jfTi-T1fXFcjpZJRWhIiZCKlxILCnBSnAjheSGppqrgiiiuRiTgiHBOOuVPBUpZZoxhjUqqWAlTukInO5215u8MTpbe9so32X_d_TC2U6o7FP1Yr3JQqPqutdpZreEZCxjUtJviRBrag</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Kawashima, Hideo</creator><creator>Kawaguchi, Hiroaki</creator><creator>Umekita, Yoshihisa</creator><creator>Souda, Masakazu</creator><creator>Gejima, Kentaro</creator><creator>Komokata, Teruo</creator><creator>Sakata, Ryuzo</creator><creator>Yoshida, Hiroki</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20081101</creationdate><title>Effects of Neonatal Administration of Diethylstilbestrol on Aberrant Crypt Foci Induced by 7,12-Dimethylbenz[α]anthracene in Rats</title><author>Kawashima, Hideo ; Kawaguchi, Hiroaki ; Umekita, Yoshihisa ; Souda, Masakazu ; Gejima, Kentaro ; Komokata, Teruo ; Sakata, Ryuzo ; Yoshida, Hiroki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-89a1c919321a87e9897e35d7ac2a2d7842c608676193b58536d6661d0f386f153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</topic><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Atrophy</topic><topic>Carcinogens - administration & dosage</topic><topic>Carcinogens - toxicity</topic><topic>Colon - drug effects</topic><topic>Colon - pathology</topic><topic>Diethylstilbestrol - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - chemically induced</topic><topic>Gastrointestinal Neoplasms - pathology</topic><topic>Intubation, Gastrointestinal</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rectum - drug effects</topic><topic>Rectum - pathology</topic><topic>Sperm Count</topic><topic>Testis - abnormalities</topic><topic>Testis - drug effects</topic><topic>Testis - pathology</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawashima, Hideo</creatorcontrib><creatorcontrib>Kawaguchi, Hiroaki</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>Souda, Masakazu</creatorcontrib><creatorcontrib>Gejima, Kentaro</creatorcontrib><creatorcontrib>Komokata, Teruo</creatorcontrib><creatorcontrib>Sakata, Ryuzo</creatorcontrib><creatorcontrib>Yoshida, Hiroki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawashima, Hideo</au><au>Kawaguchi, Hiroaki</au><au>Umekita, Yoshihisa</au><au>Souda, Masakazu</au><au>Gejima, Kentaro</au><au>Komokata, Teruo</au><au>Sakata, Ryuzo</au><au>Yoshida, Hiroki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Neonatal Administration of Diethylstilbestrol on Aberrant Crypt Foci Induced by 7,12-Dimethylbenz[α]anthracene in Rats</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>22</volume><issue>6</issue><spage>699</spage><pages>699-</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Gastrointestinal carcinoma is affected environmental factors, however, it remains to be determined whether neonatal administration
of an estrogenic endocrine disruptor, such as diethylstilbestrol (DES), affects gastrointestinal carcinogenesis. The effects
of neonatally administered DES on gastrointestinal tumorigenesis induced by 7,12-dimethylbenz[α]anthracene (DMBA) were investigated
in male and female rats. Male and female rats in group I were daily administered oil alone from 0-14 days after birth. Male
and female rats in groups II and III were daily administered DES at 1 and 10 μg/rat, respectively. The administration periods
of DES in subgroups a (IIa and IIIa), b (IIb and IIIb) and c (IIc and IIIc) were from 0-14, 0-5 and 6-14 days after birth,
respectively. At 28, 42 and 56 days after birth, all male rats were given 10 mg of DMBA. At 50 days after birth, all female
rats were given 10 mg of DMBA. In the digestive tracts of male rats, forestomach masses (FMs) in all groups (13-58%), small
intestine masses in group IIIa (17%), and colon masses (CMs) in groups IIIa (8%) and IIIb (33%) were observed, although there
were no significant changes in the incidence and number. In the digestive tracts of female rats, FMs in groups I (10%), IIa
(13%), IIb (33%), IIc (25%) and IIIc (33%), CMs in groups IIa (6%) and IIIa (6%) were seen, although there were no significant
changes in the incidence. Aberrant crypt foci (ACF) in the colon and rectum were seen in all male and female rats. The neonatal
administration of DES in male rats increased the number of ACF while that in female rats did not. These results suggest that
neonatal administration of DES may affect male colorectal carcinogenesis.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>19180994</pmid></addata></record> |
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| ispartof | In vivo (Athens), 2008-11, Vol.22 (6), p.699 |
| issn | 0258-851X 1791-7549 |
| language | eng |
| recordid | cdi_pubmed_primary_19180994 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | 9,10-Dimethyl-1,2-benzanthracene - administration & dosage 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Animals, Newborn Atrophy Carcinogens - administration & dosage Carcinogens - toxicity Colon - drug effects Colon - pathology Diethylstilbestrol - pharmacology Dose-Response Relationship, Drug Female Gastrointestinal Neoplasms - chemically induced Gastrointestinal Neoplasms - pathology Intubation, Gastrointestinal Male Rats Rats, Sprague-Dawley Rectum - drug effects Rectum - pathology Sperm Count Testis - abnormalities Testis - drug effects Testis - pathology Weaning |
| title | Effects of Neonatal Administration of Diethylstilbestrol on Aberrant Crypt Foci Induced by 7,12-Dimethylbenz[α]anthracene in Rats |
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