Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats

Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas Submitted 8 September 2008 ; accepted in final form 28 January 2009 The antioxidant -lipoic acid (LA) has been shown to improve insulin action in high-fat (HF)-fed animal models, yet little i...

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Veröffentlicht in:	Journal of applied physiology (1985) 2009-04, Vol.106 (4), p.1425-1434
Hauptverfasser:	Gupte, Anisha A, Bomhoff, Gregory L, Morris, Jill K, Gorres, Brittany K, Geiger, Paige C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Blotting, Western Body Weight - drug effects Cells, Cultured Diet Dietary Fats - pharmacology Enzyme Inhibitors - pharmacology Glucose Glucose - metabolism Heat shock proteins Heat-Shock Proteins - biosynthesis I-kappa B Kinase - biosynthesis Insulin Insulin - physiology JNK Mitogen-Activated Protein Kinases - metabolism Male MAP Kinase Signaling System - drug effects Muscle, Skeletal - physiology Musculoskeletal system p38 Mitogen-Activated Protein Kinases - metabolism Protein Kinases - metabolism Rats Rats, Wistar Rodents Signal Transduction - drug effects Stimulation, Chemical Thioctic Acid - pharmacology
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