Stem Cell Fate Dictated Solely by Altered Nanotube Dimension

Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. Here, we demonstrate such paths by controlling only the nanotopography of culture substrates. Altering the dimensions o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (7), p.2130-2135
Hauptverfasser:	Oh, Seunghan, Brammer, Karla S., Li, Y. S. Julie, Teng, Dayu, Engler, Adam J., Chien, Shu, Jin, Sungho
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Biomaterials Cell Adhesion Cell adhesion & migration Cell aggregates Cell cycle Cell Differentiation Cell division Cell growth Cell Lineage Cell lines Cell Proliferation Cultured cells Cytoskeleton Humans Immune System Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Metal Nanoparticles - chemistry Microscopy, Electron, Scanning Microscopy, Fluorescence - methods Nanotechnology - methods Nanotubes Nanotubes - chemistry Osteoblasts Osteoblasts - metabolism Physical Sciences Stem cells Stem Cells - cytology Titanium Titanium - chemistry
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