Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs After Immune Activation
To study the effects of immune cell activation by a protein antigen or lymphoid tissue derived cytokines on peripheral steroidogenesis activities of 3β HSD and 17β HSD was measured in lymphoid organs of control and BSA immunized mice after 3 weeks treatment. We demonstrated the presence of 3βHSD and...
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| Veröffentlicht in: | Immunological investigations 2009, Vol.38 (1), p.14-30 |
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| container_title | Immunological investigations |
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| creator | Mukhopadhyay, Rupanjan Mishra, Manoj K. Basu, Anirban Bishayi, Biswadev |
| description | To study the effects of immune cell activation by a protein antigen or lymphoid tissue derived cytokines on peripheral steroidogenesis activities of 3β HSD and 17β HSD was measured in lymphoid organs of control and BSA immunized mice after 3 weeks treatment. We demonstrated the presence of 3βHSD and 17βHSD in the lymphoid organs after active immunization. We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-α, IL-12p70, and IL-6, among which IL-12p70 and TNF-α down-regulate the activity of steroidogenic enzymes in the thymus during an immune response. |
| doi_str_mv | 10.1080/08820130802480570 |
| format | Article |
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We demonstrated the presence of 3βHSD and 17βHSD in the lymphoid organs after active immunization. We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-α, IL-12p70, and IL-6, among which IL-12p70 and TNF-α down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.</description><identifier>ISSN: 0882-0139</identifier><identifier>EISSN: 1532-4311</identifier><identifier>DOI: 10.1080/08820130802480570</identifier><identifier>PMID: 19172483</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>3-Hydroxysteroid Dehydrogenases - genetics ; 3-Hydroxysteroid Dehydrogenases - immunology ; 3-Hydroxysteroid Dehydrogenases - metabolism ; Animals ; Cattle ; Corticosterone - blood ; Cytokines ; Cytokines - genetics ; Cytokines - immunology ; Cytokines - metabolism ; Estradiol Dehydrogenases - genetics ; Estradiol Dehydrogenases - immunology ; Estradiol Dehydrogenases - metabolism ; Freund's Adjuvant ; Gene Expression Regulation, Enzymologic ; Glucocorticoid ; HPA axis ; Immunity ; Immunization ; Lymphocyte Activation - genetics ; Lymphoid organs ; Lymphoid Tissue - enzymology ; Lymphoid Tissue - immunology ; Male ; Mice ; Organ Specificity ; Serum Albumin, Bovine ; Steroidogenic enzymes ; Transcriptional Activation - immunology</subject><ispartof>Immunological investigations, 2009, Vol.38 (1), p.14-30</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-5a20ef6e01699b2843a38d171902660c0b129312f3a600b76850fe9e3d5f841c3</citedby><cites>FETCH-LOGICAL-c404t-5a20ef6e01699b2843a38d171902660c0b129312f3a600b76850fe9e3d5f841c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/08820130802480570$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/08820130802480570$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19172483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukhopadhyay, Rupanjan</creatorcontrib><creatorcontrib>Mishra, Manoj K.</creatorcontrib><creatorcontrib>Basu, Anirban</creatorcontrib><creatorcontrib>Bishayi, Biswadev</creatorcontrib><title>Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs After Immune Activation</title><title>Immunological investigations</title><addtitle>Immunol Invest</addtitle><description>To study the effects of immune cell activation by a protein antigen or lymphoid tissue derived cytokines on peripheral steroidogenesis activities of 3β HSD and 17β HSD was measured in lymphoid organs of control and BSA immunized mice after 3 weeks treatment. We demonstrated the presence of 3βHSD and 17βHSD in the lymphoid organs after active immunization. We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-α, IL-12p70, and IL-6, among which IL-12p70 and TNF-α down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.</description><subject>3-Hydroxysteroid Dehydrogenases - genetics</subject><subject>3-Hydroxysteroid Dehydrogenases - immunology</subject><subject>3-Hydroxysteroid Dehydrogenases - metabolism</subject><subject>Animals</subject><subject>Cattle</subject><subject>Corticosterone - blood</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Estradiol Dehydrogenases - genetics</subject><subject>Estradiol Dehydrogenases - immunology</subject><subject>Estradiol Dehydrogenases - metabolism</subject><subject>Freund's Adjuvant</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Glucocorticoid</subject><subject>HPA axis</subject><subject>Immunity</subject><subject>Immunization</subject><subject>Lymphocyte Activation - genetics</subject><subject>Lymphoid organs</subject><subject>Lymphoid Tissue - enzymology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Organ Specificity</subject><subject>Serum Albumin, Bovine</subject><subject>Steroidogenic enzymes</subject><subject>Transcriptional Activation - immunology</subject><issn>0882-0139</issn><issn>1532-4311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoOj9-gDeSK--qJ0nbtejNED8GG7vQXYc0TVykTWbSKvXXG91ARPDqBM7zvJy8CJ0SuCBQwCUUBQXC4pOmBWRj2EEjkjGapIyQXTT62icRKA_QYQgvAMCyvNxHB6Qk46iwEVrOXd03ojPOYqfxY6e8M7V7VtZIfGs_hlYFbCye995YhWdDu15FAC_8s7ABT3QU8LRt-7icyM68fUcdoz0tmqBOtvMILe9un24ektnifnozmSUyhbRLMkFB6VwBycuyokXKBCtqMiYl0DwHCRWhJSNUM5EDVOO8yECrUrE600VKJDtC55vctXevvQodb02QqmmEVa4PPI8GjX-NINmA0rsQvNJ87U0r_MAJ8K8u-Z8uo3O2De-rVtU_xra8CFxvAGO18614d76peSeGxnnthZUmcPZf_tUvfaVE062k8Iq_uN7bWNw_130C3QGS9w</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Mukhopadhyay, Rupanjan</creator><creator>Mishra, Manoj K.</creator><creator>Basu, Anirban</creator><creator>Bishayi, Biswadev</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs After Immune Activation</title><author>Mukhopadhyay, Rupanjan ; Mishra, Manoj K. ; Basu, Anirban ; Bishayi, Biswadev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-5a20ef6e01699b2843a38d171902660c0b129312f3a600b76850fe9e3d5f841c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>3-Hydroxysteroid Dehydrogenases - genetics</topic><topic>3-Hydroxysteroid Dehydrogenases - immunology</topic><topic>3-Hydroxysteroid Dehydrogenases - metabolism</topic><topic>Animals</topic><topic>Cattle</topic><topic>Corticosterone - blood</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>Estradiol Dehydrogenases - genetics</topic><topic>Estradiol Dehydrogenases - immunology</topic><topic>Estradiol Dehydrogenases - metabolism</topic><topic>Freund's Adjuvant</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Glucocorticoid</topic><topic>HPA axis</topic><topic>Immunity</topic><topic>Immunization</topic><topic>Lymphocyte Activation - genetics</topic><topic>Lymphoid organs</topic><topic>Lymphoid Tissue - enzymology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Organ Specificity</topic><topic>Serum Albumin, Bovine</topic><topic>Steroidogenic enzymes</topic><topic>Transcriptional Activation - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukhopadhyay, Rupanjan</creatorcontrib><creatorcontrib>Mishra, Manoj K.</creatorcontrib><creatorcontrib>Basu, Anirban</creatorcontrib><creatorcontrib>Bishayi, Biswadev</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunological investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukhopadhyay, Rupanjan</au><au>Mishra, Manoj K.</au><au>Basu, Anirban</au><au>Bishayi, Biswadev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs After Immune Activation</atitle><jtitle>Immunological investigations</jtitle><addtitle>Immunol Invest</addtitle><date>2009</date><risdate>2009</risdate><volume>38</volume><issue>1</issue><spage>14</spage><epage>30</epage><pages>14-30</pages><issn>0882-0139</issn><eissn>1532-4311</eissn><abstract>To study the effects of immune cell activation by a protein antigen or lymphoid tissue derived cytokines on peripheral steroidogenesis activities of 3β HSD and 17β HSD was measured in lymphoid organs of control and BSA immunized mice after 3 weeks treatment. We demonstrated the presence of 3βHSD and 17βHSD in the lymphoid organs after active immunization. We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-α, IL-12p70, and IL-6, among which IL-12p70 and TNF-α down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19172483</pmid><doi>10.1080/08820130802480570</doi><tpages>17</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | 3-Hydroxysteroid Dehydrogenases - genetics 3-Hydroxysteroid Dehydrogenases - immunology 3-Hydroxysteroid Dehydrogenases - metabolism Animals Cattle Corticosterone - blood Cytokines Cytokines - genetics Cytokines - immunology Cytokines - metabolism Estradiol Dehydrogenases - genetics Estradiol Dehydrogenases - immunology Estradiol Dehydrogenases - metabolism Freund's Adjuvant Gene Expression Regulation, Enzymologic Glucocorticoid HPA axis Immunity Immunization Lymphocyte Activation - genetics Lymphoid organs Lymphoid Tissue - enzymology Lymphoid Tissue - immunology Male Mice Organ Specificity Serum Albumin, Bovine Steroidogenic enzymes Transcriptional Activation - immunology |
| title | Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs After Immune Activation |
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