Recurrent acute liver toxicity from intravenous methylprednisolone
Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation impr...
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| Veröffentlicht in: | Revista española de enfermedades digestivas 2008-11, Vol.100 (11), p.720 |
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| creator | Rivero Fernández, M Riesco, J M Moreira, V F Moreno, A López San Román, A Arranz, G Ruiz Del Arbol, L |
| description | Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture.Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the case of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. In the third episode a liver biopsy was performed, which showed acute hepatitis with bridging necrosis; such histological picture has not been described before in patients treated with intravenous steroids. |
| format | Article |
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An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture.Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the case of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. 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An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture.Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the case of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. In the third episode a liver biopsy was performed, which showed acute hepatitis with bridging necrosis; such histological picture has not been described before in patients treated with intravenous steroids.</description><subject>Acute Disease</subject><subject>Biopsy</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Liver - pathology</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - adverse effects</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis, Relapsing-Remitting - drug therapy</subject><subject>Necrosis</subject><subject>Recurrence</subject><issn>1130-0108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z8tKxDAUgOEsFGccfQXJCxRymjaXpQ7eYGBAdD3kcoKRtilJOti3d6Gu_t0H_wXZAnDWMGBqQ65L-WKs46Jvr8gGNPQapNqShzd0S844VWrcUpEO8YyZ1vQdXawrDTmNNE41mzNOaSl0xPq5DnNGP8WShjThDbkMZih4-9cd-Xh6fN-_NIfj8-v-_tDMwHVtrODOQqeC4ExYIyVvRZA8SM0BVOew10FaY5RrezC-9U45NGCF8xK8D3xH7n7debEj-tOc42jyevqf4T8IvUcs</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Rivero Fernández, M</creator><creator>Riesco, J M</creator><creator>Moreira, V F</creator><creator>Moreno, A</creator><creator>López San Román, A</creator><creator>Arranz, G</creator><creator>Ruiz Del Arbol, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200811</creationdate><title>Recurrent acute liver toxicity from intravenous methylprednisolone</title><author>Rivero Fernández, M ; Riesco, J M ; Moreira, V F ; Moreno, A ; López San Román, A ; Arranz, G ; Ruiz Del Arbol, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-b63cb148f6306ba77326f73f7931184ce59f7baa8c251ad2dc8cea1b6cd71ddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2008</creationdate><topic>Acute Disease</topic><topic>Biopsy</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Liver - pathology</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Methylprednisolone - adverse effects</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis, Relapsing-Remitting - drug therapy</topic><topic>Necrosis</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rivero Fernández, M</creatorcontrib><creatorcontrib>Riesco, J M</creatorcontrib><creatorcontrib>Moreira, V F</creatorcontrib><creatorcontrib>Moreno, A</creatorcontrib><creatorcontrib>López San Román, A</creatorcontrib><creatorcontrib>Arranz, G</creatorcontrib><creatorcontrib>Ruiz Del Arbol, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Revista española de enfermedades digestivas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivero Fernández, M</au><au>Riesco, J M</au><au>Moreira, V F</au><au>Moreno, A</au><au>López San Román, A</au><au>Arranz, G</au><au>Ruiz Del Arbol, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent acute liver toxicity from intravenous methylprednisolone</atitle><jtitle>Revista española de enfermedades digestivas</jtitle><addtitle>Rev Esp Enferm Dig</addtitle><date>2008-11</date><risdate>2008</risdate><volume>100</volume><issue>11</issue><spage>720</spage><pages>720-</pages><issn>1130-0108</issn><abstract>Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. 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| ispartof | Revista española de enfermedades digestivas, 2008-11, Vol.100 (11), p.720 |
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| language | spa |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Biopsy Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Female Humans Injections, Intravenous Liver - pathology Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Middle Aged Multiple Sclerosis, Relapsing-Remitting - drug therapy Necrosis Recurrence |
| title | Recurrent acute liver toxicity from intravenous methylprednisolone |
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