Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia

Schizophrenia symptoms can be segregated into positive, negative and cognitive, which exhibit differential sensitivity to drug treatments. Accumulating evidence points to efficacy of alpha7 nicotinic receptor (nAChR) agonists for cognitive deficits in schizophrenia but their activity against positiv...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2009-06, Vol.34 (7), p.1753
Hauptverfasser:	Barak, Segev, Arad, Michal, De Levie, Amaya, Black, Mark D, Griebel, Guy, Weiner, Ina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation - adverse effects alpha7 Nicotinic Acetylcholine Receptor Analysis of Variance Animals Animals, Newborn Behavior, Animal - drug effects Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Cognition Disorders - drug therapy Cognition Disorders - etiology Conditioning (Psychology) - drug effects Disease Models, Animal Dizocilpine Maleate - therapeutic use Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Male Neural Inhibition - drug effects Neuroprotective Agents - therapeutic use Nicotinic Agonists - therapeutic use Nitroarginine - pharmacology Rats Rats, Wistar Receptors, Nicotinic Reinforcement (Psychology) Schizophrenia - complications Schizophrenia - drug therapy
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