Factors of therapeutic imbalance of antivitamins K and their haemorrhagic consequences in elderly
Objective. To determinate, for older subjects, specific factors of imbalance of the oral anticoagulant treatments. Method. We conducted an epidemiological and analytical case-control study, during 18 months, in 2 geriatrics centers. Each patient with excessive anticoagulation (INR>4.5) was matche...
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| Veröffentlicht in: | Therapie 2008-09, Vol.63 (5), p.393 |
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| creator | Chatap, Guy Giraud, Karine Delay, Virginie Cassereau, Catherine Bastuji-Garin, Sylvie Vincent, Jean-Pierre Cornu, Henri-Pierre |
| description | Objective. To determinate, for older subjects, specific factors of imbalance of the oral anticoagulant treatments. Method. We conducted an epidemiological and analytical case-control study, during 18 months, in 2 geriatrics centers. Each patient with excessive anticoagulation (INR>4.5) was matched with 2 controls under anticoagulant, whom the INR (international normalized ratio) had stayed in the therapeutic range. Results. One-hundred fifty nine subjects (53 cases and 106 controls) were included. Haemorrhagic complications has been observed in 19.2% of cases, versus 3.9% of the controls. Some medicines frequently prescribed to the old subjects were correlated at a risk of excessive anticoagulation: amiodarone (9.4% versus 0, p |
| doi_str_mv | 10.2515/therapie:2008058 |
| format | Article |
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To determinate, for older subjects, specific factors of imbalance of the oral anticoagulant treatments. Method. We conducted an epidemiological and analytical case-control study, during 18 months, in 2 geriatrics centers. Each patient with excessive anticoagulation (INR>4.5) was matched with 2 controls under anticoagulant, whom the INR (international normalized ratio) had stayed in the therapeutic range. Results. One-hundred fifty nine subjects (53 cases and 106 controls) were included. Haemorrhagic complications has been observed in 19.2% of cases, versus 3.9% of the controls. Some medicines frequently prescribed to the old subjects were correlated at a risk of excessive anticoagulation: amiodarone (9.4% versus 0, p<0.004), acetaminophen (18.9% versus 0.9%, p<0.001), tramadol (5.6% versus 0, p<0.04), ofloxacine (11.3% versus 1.9%, p<0.001), and lactulose (11.3% versus 0, p<0.001). Furthermore, several acute states increase the risk of excessive INR to the old subjects: fever (p<0.001), malnutrition (p<0.001), dehydration (p=0.006), and acute diarrhea (p<0.001). Conclusion. Some specific geriatric factors raised may destabilize treatments by anticoagulants.]]></description><identifier>ISSN: 0040-5957</identifier><identifier>DOI: 10.2515/therapie:2008058</identifier><identifier>PMID: 19154709</identifier><language>fre</language><publisher>France</publisher><subject>4-Hydroxycoumarins - antagonists & inhibitors ; Aged ; Aged, 80 and over ; Anticoagulants - antagonists & inhibitors ; Case-Control Studies ; Drug Interactions ; Female ; Health Services for the Aged ; Hemorrhage - chemically induced ; Humans ; Indenes - antagonists & inhibitors ; Male ; Vitamin K - antagonists & inhibitors</subject><ispartof>Therapie, 2008-09, Vol.63 (5), p.393</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19154709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chatap, Guy</creatorcontrib><creatorcontrib>Giraud, Karine</creatorcontrib><creatorcontrib>Delay, Virginie</creatorcontrib><creatorcontrib>Cassereau, Catherine</creatorcontrib><creatorcontrib>Bastuji-Garin, Sylvie</creatorcontrib><creatorcontrib>Vincent, Jean-Pierre</creatorcontrib><creatorcontrib>Cornu, Henri-Pierre</creatorcontrib><title>Factors of therapeutic imbalance of antivitamins K and their haemorrhagic consequences in elderly</title><title>Therapie</title><addtitle>Therapie</addtitle><description><![CDATA[Objective. To determinate, for older subjects, specific factors of imbalance of the oral anticoagulant treatments. Method. We conducted an epidemiological and analytical case-control study, during 18 months, in 2 geriatrics centers. Each patient with excessive anticoagulation (INR>4.5) was matched with 2 controls under anticoagulant, whom the INR (international normalized ratio) had stayed in the therapeutic range. Results. One-hundred fifty nine subjects (53 cases and 106 controls) were included. Haemorrhagic complications has been observed in 19.2% of cases, versus 3.9% of the controls. Some medicines frequently prescribed to the old subjects were correlated at a risk of excessive anticoagulation: amiodarone (9.4% versus 0, p<0.004), acetaminophen (18.9% versus 0.9%, p<0.001), tramadol (5.6% versus 0, p<0.04), ofloxacine (11.3% versus 1.9%, p<0.001), and lactulose (11.3% versus 0, p<0.001). Furthermore, several acute states increase the risk of excessive INR to the old subjects: fever (p<0.001), malnutrition (p<0.001), dehydration (p=0.006), and acute diarrhea (p<0.001). Conclusion. Some specific geriatric factors raised may destabilize treatments by anticoagulants.]]></description><subject>4-Hydroxycoumarins - antagonists & inhibitors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticoagulants - antagonists & inhibitors</subject><subject>Case-Control Studies</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>Health Services for the Aged</subject><subject>Hemorrhage - chemically induced</subject><subject>Humans</subject><subject>Indenes - antagonists & inhibitors</subject><subject>Male</subject><subject>Vitamin K - antagonists & inhibitors</subject><issn>0040-5957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T7tOwzAU9QCipbAzIf9A4NqJ7ZoNVbQgKrHAXN04N9QoL2wHqX9PqsJ0dJ7SYexGwJ1UQt2nPQUcPD1IgCWo5RmbAxSQKavMjF3G-AUghbHmgs2EFaowYOcM1-hSHyLva35aoDF5x31bYoOdo6OBXfI_PmHru8hfJ1odsz7wPVLbh7DHz6ni-i7S90hTKXLfcWoqCs3hip3X2ES6_sMF-1g_va-es-3b5mX1uM0GkduUGSAnNBXOWGFAS-lqMlVdO4u2zEWOjrQpTYEopKm0RjsptSpAaAVaQ75gt6fdYSxbqnZD8C2Gw-7_a_4LhkFXvQ</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Chatap, Guy</creator><creator>Giraud, Karine</creator><creator>Delay, Virginie</creator><creator>Cassereau, Catherine</creator><creator>Bastuji-Garin, Sylvie</creator><creator>Vincent, Jean-Pierre</creator><creator>Cornu, Henri-Pierre</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200809</creationdate><title>Factors of therapeutic imbalance of antivitamins K and their haemorrhagic consequences in elderly</title><author>Chatap, Guy ; Giraud, Karine ; Delay, Virginie ; Cassereau, Catherine ; Bastuji-Garin, Sylvie ; Vincent, Jean-Pierre ; Cornu, Henri-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-70ec16e4c79170622cfe7dffc9a9b313ace67b74aa127d66a9acef54016506603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2008</creationdate><topic>4-Hydroxycoumarins - antagonists & inhibitors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticoagulants - antagonists & inhibitors</topic><topic>Case-Control Studies</topic><topic>Drug Interactions</topic><topic>Female</topic><topic>Health Services for the Aged</topic><topic>Hemorrhage - chemically induced</topic><topic>Humans</topic><topic>Indenes - antagonists & inhibitors</topic><topic>Male</topic><topic>Vitamin K - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chatap, Guy</creatorcontrib><creatorcontrib>Giraud, Karine</creatorcontrib><creatorcontrib>Delay, Virginie</creatorcontrib><creatorcontrib>Cassereau, Catherine</creatorcontrib><creatorcontrib>Bastuji-Garin, Sylvie</creatorcontrib><creatorcontrib>Vincent, Jean-Pierre</creatorcontrib><creatorcontrib>Cornu, Henri-Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Therapie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chatap, Guy</au><au>Giraud, Karine</au><au>Delay, Virginie</au><au>Cassereau, Catherine</au><au>Bastuji-Garin, Sylvie</au><au>Vincent, Jean-Pierre</au><au>Cornu, Henri-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors of therapeutic imbalance of antivitamins K and their haemorrhagic consequences in elderly</atitle><jtitle>Therapie</jtitle><addtitle>Therapie</addtitle><date>2008-09</date><risdate>2008</risdate><volume>63</volume><issue>5</issue><spage>393</spage><pages>393-</pages><issn>0040-5957</issn><abstract><![CDATA[Objective. To determinate, for older subjects, specific factors of imbalance of the oral anticoagulant treatments. Method. We conducted an epidemiological and analytical case-control study, during 18 months, in 2 geriatrics centers. Each patient with excessive anticoagulation (INR>4.5) was matched with 2 controls under anticoagulant, whom the INR (international normalized ratio) had stayed in the therapeutic range. Results. One-hundred fifty nine subjects (53 cases and 106 controls) were included. Haemorrhagic complications has been observed in 19.2% of cases, versus 3.9% of the controls. Some medicines frequently prescribed to the old subjects were correlated at a risk of excessive anticoagulation: amiodarone (9.4% versus 0, p<0.004), acetaminophen (18.9% versus 0.9%, p<0.001), tramadol (5.6% versus 0, p<0.04), ofloxacine (11.3% versus 1.9%, p<0.001), and lactulose (11.3% versus 0, p<0.001). Furthermore, several acute states increase the risk of excessive INR to the old subjects: fever (p<0.001), malnutrition (p<0.001), dehydration (p=0.006), and acute diarrhea (p<0.001). Conclusion. Some specific geriatric factors raised may destabilize treatments by anticoagulants.]]></abstract><cop>France</cop><pmid>19154709</pmid><doi>10.2515/therapie:2008058</doi></addata></record> |
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| subjects | 4-Hydroxycoumarins - antagonists & inhibitors Aged Aged, 80 and over Anticoagulants - antagonists & inhibitors Case-Control Studies Drug Interactions Female Health Services for the Aged Hemorrhage - chemically induced Humans Indenes - antagonists & inhibitors Male Vitamin K - antagonists & inhibitors |
| title | Factors of therapeutic imbalance of antivitamins K and their haemorrhagic consequences in elderly |
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