Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

In translation, elongation factor Tu (EF-Tu) molecules deliver aminoacyl-tRNAs to the mRNA-programmed ribosome. The GTPase activity of EF-Tu is triggered by ribosome-induced conformational changes of the factor that play a pivotal role in the selection of the cognate aminoacyl-tRNAs. We present a 6....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-01, Vol.106 (4), p.1063-1068
Hauptverfasser:	Villa, Elizabeth, Sengupta, Jayati, Trabuco, Leonardo G, LeBarron, Jamie, Baxter, William T, Shaikh, Tanvir R, Grassucci, Robert A, Nissen, Poul, Ehrenberg, Måns, Schulten, Klaus, Frank, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic interactions Biochemistry Biologi Biological Sciences Biology cryo-EM Cryoelectron Microscopy Crystal structure Decoding E coli Enzyme Activation Escherichia coli Escherichia coli - enzymology Escherichia coli - metabolism Escherichia coli Proteins - metabolism Flexible fitting GTPase Guanosine Triphosphate - metabolism Histidine - metabolism Hydrolysis Hydrophobic and Hydrophilic Interactions Microscopy Models, Molecular Molecular Biology Molecular dynamics Molecules Molekylärbiologi NATURAL SCIENCES NATURVETENSKAP Nucleotides Peptide Elongation Factor Tu - chemistry Peptide Elongation Factor Tu - ultrastructure Peptide elongation factors Protein Structure, Secondary Protein synthesis Ribosomal Proteins - metabolism Ribosomes Ribosomes - chemistry Ribosomes - metabolism Ribosomes - ultrastructure RNA, Transfer - metabolism Signal Transduction Ternary complex Transfer RNA
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