Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family
A family consisting of at least ten distinct novel 8-10 kd cytokines has been identified over the past 12 years. These cytokines exhibit from 20 to 45% homology in amino acid sequence, are probably all basic heparin-binding polypeptides, and have proinflammatory and reparative activities. The cDNA f...
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| Veröffentlicht in: | Annual review of immunology 1991-01, Vol.9 (1), p.617-648 |
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| creator | Oppenheim, J J Zachariae, C O C Mukaida, N Matsushima, K |
| description | A family consisting of at least ten distinct novel 8-10 kd cytokines has been identified over the past 12 years. These cytokines exhibit from 20 to 45% homology in amino acid sequence, are probably all basic heparin-binding polypeptides, and have proinflammatory and reparative activities. The cDNA for these cytokines are characterized by conserved single open reading frames, typical signal sequences in the 5' region, and AT rich sequences in the 3' untranslated regions. Those human cytokines known as interleukin 8, platelet factor 4, beta thromboglobulin, IP-10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features, whereas the second subset consisting of LD78, ACT-2, I-309, RANTES, and macrophage chemotactic and activating factor (MCAF) are all closely linked on human chromosome 17. In this review we have summarized and discussed the available information concerning the regulation and structure of the genes, the structure and biochemical properties of the polypeptide products, their receptors, signal transduction, cell sources, and in vitro as well as in vivo activities of these cytokines. |
| doi_str_mv | 10.1146/annurev.iy.09.040191.003153 |
| format | Article |
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These cytokines exhibit from 20 to 45% homology in amino acid sequence, are probably all basic heparin-binding polypeptides, and have proinflammatory and reparative activities. The cDNA for these cytokines are characterized by conserved single open reading frames, typical signal sequences in the 5' region, and AT rich sequences in the 3' untranslated regions. Those human cytokines known as interleukin 8, platelet factor 4, beta thromboglobulin, IP-10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features, whereas the second subset consisting of LD78, ACT-2, I-309, RANTES, and macrophage chemotactic and activating factor (MCAF) are all closely linked on human chromosome 17. In this review we have summarized and discussed the available information concerning the regulation and structure of the genes, the structure and biochemical properties of the polypeptide products, their receptors, signal transduction, cell sources, and in vitro as well as in vivo activities of these cytokines.</description><identifier>ISSN: 0732-0582</identifier><identifier>EISSN: 1545-3278</identifier><identifier>DOI: 10.1146/annurev.iy.09.040191.003153</identifier><identifier>PMID: 1910690</identifier><identifier>CODEN: ARIMDU</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Amino Acid Sequence ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Base Sequence ; Biological and medical sciences ; Cytokines - genetics ; Cytokines - immunology ; DNA - genetics ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Inflammation - genetics ; Inflammation - immunology ; Miscellaneous ; Molecular Sequence Data ; Multigene Family ; Receptors, Immunologic ; Regulatory factors and their cellular receptors</subject><ispartof>Annual review of immunology, 1991-01, Vol.9 (1), p.617-648</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a524t-f3553590b587a734c70e001172f37ef2d34b5c7ae17b6648e0dc3091387d7f4a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.iy.09.040191.003153?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.iy.09.040191.003153$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19694880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1910690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oppenheim, J J</creatorcontrib><creatorcontrib>Zachariae, C O C</creatorcontrib><creatorcontrib>Mukaida, N</creatorcontrib><creatorcontrib>Matsushima, K</creatorcontrib><title>Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family</title><title>Annual review of immunology</title><addtitle>Annu Rev Immunol</addtitle><description>A family consisting of at least ten distinct novel 8-10 kd cytokines has been identified over the past 12 years. These cytokines exhibit from 20 to 45% homology in amino acid sequence, are probably all basic heparin-binding polypeptides, and have proinflammatory and reparative activities. The cDNA for these cytokines are characterized by conserved single open reading frames, typical signal sequences in the 5' region, and AT rich sequences in the 3' untranslated regions. Those human cytokines known as interleukin 8, platelet factor 4, beta thromboglobulin, IP-10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features, whereas the second subset consisting of LD78, ACT-2, I-309, RANTES, and macrophage chemotactic and activating factor (MCAF) are all closely linked on human chromosome 17. In this review we have summarized and discussed the available information concerning the regulation and structure of the genes, the structure and biochemical properties of the polypeptide products, their receptors, signal transduction, cell sources, and in vitro as well as in vivo activities of these cytokines.</description><subject>Amino Acid Sequence</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>DNA - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Inflammation - genetics</subject><subject>Inflammation - immunology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Receptors, Immunologic</subject><subject>Regulatory factors and their cellular receptors</subject><issn>0732-0582</issn><issn>1545-3278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtKxDAUhoMoOl4eQSiK7lpPmqRpcaMM3kBUUNch0znRaC9j0ip9ezN0QHfiKiHn-88fPkIOKSSU8uxEN03v8DOxQwJFAhxoQRMARgVbIxMquIhZKvN1MgHJ0hhEnm6Rbe_fAKBgTG6SzZCArIAJuXtw7QJdZ9FHrYm6V4zu2k-sovBuG1PputZd64bosQ_YCzYYHdw0HbrS2QYPounQte_hFl3q2lbDLtkwuvK4tzp3yPPlxdP0Or69v7qZnt_GWqS8iw0TgokCZiKXWjJeSkAASmVqmESTzhmfiVJqpHKWZTxHmJcMCspyOZeGa7ZDjse9C9d-9Og7VVtfYlXpBtveK5mGZQLEnyDNQGSZZAE8HcHStd47NGrhbK3doCiopXa10q7soKBQo3Y1ag_p_VVNP6tx_pMdPYf50Wqufakr43RTWv8Lywqe50vubOSWZboKdRa__L--8g2yx6Mf</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Oppenheim, J J</creator><creator>Zachariae, C O C</creator><creator>Mukaida, N</creator><creator>Matsushima, K</creator><general>Annual Reviews</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910101</creationdate><title>Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family</title><author>Oppenheim, J J ; Zachariae, C O C ; Mukaida, N ; Matsushima, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a524t-f3553590b587a734c70e001172f37ef2d34b5c7ae17b6648e0dc3091387d7f4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino Acid Sequence</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>DNA - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Inflammation - genetics</topic><topic>Inflammation - immunology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Receptors, Immunologic</topic><topic>Regulatory factors and their cellular receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oppenheim, J J</creatorcontrib><creatorcontrib>Zachariae, C O C</creatorcontrib><creatorcontrib>Mukaida, N</creatorcontrib><creatorcontrib>Matsushima, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oppenheim, J J</au><au>Zachariae, C O C</au><au>Mukaida, N</au><au>Matsushima, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family</atitle><jtitle>Annual review of immunology</jtitle><addtitle>Annu Rev Immunol</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>9</volume><issue>1</issue><spage>617</spage><epage>648</epage><pages>617-648</pages><issn>0732-0582</issn><eissn>1545-3278</eissn><coden>ARIMDU</coden><abstract>A family consisting of at least ten distinct novel 8-10 kd cytokines has been identified over the past 12 years. These cytokines exhibit from 20 to 45% homology in amino acid sequence, are probably all basic heparin-binding polypeptides, and have proinflammatory and reparative activities. The cDNA for these cytokines are characterized by conserved single open reading frames, typical signal sequences in the 5' region, and AT rich sequences in the 3' untranslated regions. Those human cytokines known as interleukin 8, platelet factor 4, beta thromboglobulin, IP-10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features, whereas the second subset consisting of LD78, ACT-2, I-309, RANTES, and macrophage chemotactic and activating factor (MCAF) are all closely linked on human chromosome 17. 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| ispartof | Annual review of immunology, 1991-01, Vol.9 (1), p.617-648 |
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| language | eng |
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| source | Annual Reviews; MEDLINE |
| subjects | Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Base Sequence Biological and medical sciences Cytokines - genetics Cytokines - immunology DNA - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Inflammation - genetics Inflammation - immunology Miscellaneous Molecular Sequence Data Multigene Family Receptors, Immunologic Regulatory factors and their cellular receptors |
| title | Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family |
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