Modulation of the Voltage-Gated Potassium Channel Kv1.5 by the SGK1 Protein Kinase Involves Inhibition of Channel Ubiquitination

The serum and glucocorticoid inducible kinase SGK1 is involved in dexamethasone-induced inhibition of insulin secretion by increasing voltage-gated potassium channel (Kv) activity. SGK1 upregulates the Kv1.5 channel but the precise mechanism underlying the SGK1 dependent regulation of Kv1.5 has not...

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Veröffentlicht in:	Cellular physiology and biochemistry 2008-01, Vol.22 (5-6), p.591-600
Hauptverfasser:	Boehmer, Christoph, Laufer, Jörg, Jeyaraj, Sankarganesh, Klaus, Fabian, Lindner, Ricco, Lang, Florian, Palmada, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - drug effects Cell Membrane - metabolism Dexamethasone - pharmacology Endosomal Sorting Complexes Required for Transport Immediate-Early Proteins - metabolism Insulin - pharmacology Ion Channel Gating - drug effects Kinetics Kv1.5 Potassium Channel - metabolism Nedd4 Ubiquitin Protein Ligases Original Paper Protein-Serine-Threonine Kinases - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination - drug effects Xenopus - metabolism Xenopus Proteins
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