Effects of ramipril and simvastatin on the oxidative stress of diabetic rats
To evaluate if ramipril, with or without simultaneous use of simvastatin, would be capable of reducing oxidative stress of streptozotocin (STZ) induced diabetic rats. The drugs were given to the diabetic rats for 2 weeks; oxidative stress was measured by dosage of total plasma antioxidant capacity (...
Gespeichert in:
| Veröffentlicht in: | Arquivos brasileiros de endocrinologia e metabologia 2008-10, Vol.52 (7), p.1131 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | por |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | 1131 |
| container_title | Arquivos brasileiros de endocrinologia e metabologia |
| container_volume | 52 |
| creator | Elias, José A Z Delfino, Vinicius D A Barbosa, Décio S Fabris, Bruno A Matsuo, Tiemi |
| description | To evaluate if ramipril, with or without simultaneous use of simvastatin, would be capable of reducing oxidative stress of streptozotocin (STZ) induced diabetic rats.
The drugs were given to the diabetic rats for 2 weeks; oxidative stress was measured by dosage of total plasma antioxidant capacity (TRAP) and malondialdehyde (MDA).
Ramipril, used alone, was capable of significantly increasing the antioxidative defenses of the diabetic rat; simvastatin, given alone or combined with ramipril in separate administrations, did not produce any significant effect on the oxidative stress; concomitant administration of ramipril and simvastatin significantly reduced the antioxidative plasmatic defenses of rats with chemically induced diabetes mellitus
Our data corroborate the positive effect of ramipril upon plasma antioxidative defenses but did not confirm a possible beneficial effect of simvastatin in the model. More research is needed to clarify the paradoxal TRAP reduction verified with simultaneous administration of the drugs. |
| doi_str_mv | 10.1590/S0004-27302008000700009 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_19082301</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19082301</sourcerecordid><originalsourceid>FETCH-LOGICAL-p140t-a9a06086eb9dc192dd0ea8b7c6af92dcf919231fb70ebc5fcfa41839957d5cea3</originalsourceid><addsrcrecordid>eNo1j9tKxDAQhoMg7rr6CpoXqE6StslcyrK6QsEL9XqZ5oCRbbc0cdG3N3i4-Bm-gW-Yn7FrATeiQbh9BoC6klqBBDAFdAngCVuKVusKa6MX7DyldwBZI8ozthAIRioQS9ZtQvA2J34IfKYhTnPccxodT3E4UsqU48gPI89vnh8-oyt89Dzl2acfx0XqfY62yDldsNNA--Qv_-aKvd5vXtbbqnt6eFzfddUkasgVIUELpvU9OitQOgeeTK9tS6GQDViWSoReg-9tE2ygWhiF2GjXWE9qxa5-704f_eDdrjw90Py1-6-lvgFRKVAx</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of ramipril and simvastatin on the oxidative stress of diabetic rats</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Elias, José A Z ; Delfino, Vinicius D A ; Barbosa, Décio S ; Fabris, Bruno A ; Matsuo, Tiemi</creator><creatorcontrib>Elias, José A Z ; Delfino, Vinicius D A ; Barbosa, Décio S ; Fabris, Bruno A ; Matsuo, Tiemi</creatorcontrib><description>To evaluate if ramipril, with or without simultaneous use of simvastatin, would be capable of reducing oxidative stress of streptozotocin (STZ) induced diabetic rats.
The drugs were given to the diabetic rats for 2 weeks; oxidative stress was measured by dosage of total plasma antioxidant capacity (TRAP) and malondialdehyde (MDA).
Ramipril, used alone, was capable of significantly increasing the antioxidative defenses of the diabetic rat; simvastatin, given alone or combined with ramipril in separate administrations, did not produce any significant effect on the oxidative stress; concomitant administration of ramipril and simvastatin significantly reduced the antioxidative plasmatic defenses of rats with chemically induced diabetes mellitus
Our data corroborate the positive effect of ramipril upon plasma antioxidative defenses but did not confirm a possible beneficial effect of simvastatin in the model. More research is needed to clarify the paradoxal TRAP reduction verified with simultaneous administration of the drugs.</description><identifier>EISSN: 1677-9487</identifier><identifier>DOI: 10.1590/S0004-27302008000700009</identifier><identifier>PMID: 19082301</identifier><language>por</language><publisher>Brazil</publisher><subject>Analysis of Variance ; Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Animals ; Antioxidants - administration & dosage ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Drug Evaluation, Preclinical ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Male ; Oxidative Stress - drug effects ; Ramipril - administration & dosage ; Random Allocation ; Rats ; Simvastatin - administration & dosage ; Statistics, Nonparametric</subject><ispartof>Arquivos brasileiros de endocrinologia e metabologia, 2008-10, Vol.52 (7), p.1131</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19082301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elias, José A Z</creatorcontrib><creatorcontrib>Delfino, Vinicius D A</creatorcontrib><creatorcontrib>Barbosa, Décio S</creatorcontrib><creatorcontrib>Fabris, Bruno A</creatorcontrib><creatorcontrib>Matsuo, Tiemi</creatorcontrib><title>Effects of ramipril and simvastatin on the oxidative stress of diabetic rats</title><title>Arquivos brasileiros de endocrinologia e metabologia</title><addtitle>Arq Bras Endocrinol Metabol</addtitle><description>To evaluate if ramipril, with or without simultaneous use of simvastatin, would be capable of reducing oxidative stress of streptozotocin (STZ) induced diabetic rats.
The drugs were given to the diabetic rats for 2 weeks; oxidative stress was measured by dosage of total plasma antioxidant capacity (TRAP) and malondialdehyde (MDA).
Ramipril, used alone, was capable of significantly increasing the antioxidative defenses of the diabetic rat; simvastatin, given alone or combined with ramipril in separate administrations, did not produce any significant effect on the oxidative stress; concomitant administration of ramipril and simvastatin significantly reduced the antioxidative plasmatic defenses of rats with chemically induced diabetes mellitus
Our data corroborate the positive effect of ramipril upon plasma antioxidative defenses but did not confirm a possible beneficial effect of simvastatin in the model. More research is needed to clarify the paradoxal TRAP reduction verified with simultaneous administration of the drugs.</description><subject>Analysis of Variance</subject><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Drug Evaluation, Preclinical</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Male</subject><subject>Oxidative Stress - drug effects</subject><subject>Ramipril - administration & dosage</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Simvastatin - administration & dosage</subject><subject>Statistics, Nonparametric</subject><issn>1677-9487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j9tKxDAQhoMg7rr6CpoXqE6StslcyrK6QsEL9XqZ5oCRbbc0cdG3N3i4-Bm-gW-Yn7FrATeiQbh9BoC6klqBBDAFdAngCVuKVusKa6MX7DyldwBZI8ozthAIRioQS9ZtQvA2J34IfKYhTnPccxodT3E4UsqU48gPI89vnh8-oyt89Dzl2acfx0XqfY62yDldsNNA--Qv_-aKvd5vXtbbqnt6eFzfddUkasgVIUELpvU9OitQOgeeTK9tS6GQDViWSoReg-9tE2ygWhiF2GjXWE9qxa5-704f_eDdrjw90Py1-6-lvgFRKVAx</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Elias, José A Z</creator><creator>Delfino, Vinicius D A</creator><creator>Barbosa, Décio S</creator><creator>Fabris, Bruno A</creator><creator>Matsuo, Tiemi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200810</creationdate><title>Effects of ramipril and simvastatin on the oxidative stress of diabetic rats</title><author>Elias, José A Z ; Delfino, Vinicius D A ; Barbosa, Décio S ; Fabris, Bruno A ; Matsuo, Tiemi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-a9a06086eb9dc192dd0ea8b7c6af92dcf919231fb70ebc5fcfa41839957d5cea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2008</creationdate><topic>Analysis of Variance</topic><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Drug Evaluation, Preclinical</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Male</topic><topic>Oxidative Stress - drug effects</topic><topic>Ramipril - administration & dosage</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Simvastatin - administration & dosage</topic><topic>Statistics, Nonparametric</topic><toplevel>online_resources</toplevel><creatorcontrib>Elias, José A Z</creatorcontrib><creatorcontrib>Delfino, Vinicius D A</creatorcontrib><creatorcontrib>Barbosa, Décio S</creatorcontrib><creatorcontrib>Fabris, Bruno A</creatorcontrib><creatorcontrib>Matsuo, Tiemi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elias, José A Z</au><au>Delfino, Vinicius D A</au><au>Barbosa, Décio S</au><au>Fabris, Bruno A</au><au>Matsuo, Tiemi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ramipril and simvastatin on the oxidative stress of diabetic rats</atitle><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle><addtitle>Arq Bras Endocrinol Metabol</addtitle><date>2008-10</date><risdate>2008</risdate><volume>52</volume><issue>7</issue><spage>1131</spage><pages>1131-</pages><eissn>1677-9487</eissn><abstract>To evaluate if ramipril, with or without simultaneous use of simvastatin, would be capable of reducing oxidative stress of streptozotocin (STZ) induced diabetic rats.
The drugs were given to the diabetic rats for 2 weeks; oxidative stress was measured by dosage of total plasma antioxidant capacity (TRAP) and malondialdehyde (MDA).
Ramipril, used alone, was capable of significantly increasing the antioxidative defenses of the diabetic rat; simvastatin, given alone or combined with ramipril in separate administrations, did not produce any significant effect on the oxidative stress; concomitant administration of ramipril and simvastatin significantly reduced the antioxidative plasmatic defenses of rats with chemically induced diabetes mellitus
Our data corroborate the positive effect of ramipril upon plasma antioxidative defenses but did not confirm a possible beneficial effect of simvastatin in the model. More research is needed to clarify the paradoxal TRAP reduction verified with simultaneous administration of the drugs.</abstract><cop>Brazil</cop><pmid>19082301</pmid><doi>10.1590/S0004-27302008000700009</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1677-9487 |
| ispartof | Arquivos brasileiros de endocrinologia e metabologia, 2008-10, Vol.52 (7), p.1131 |
| issn | 1677-9487 |
| language | por |
| recordid | cdi_pubmed_primary_19082301 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis of Variance Angiotensin-Converting Enzyme Inhibitors - administration & dosage Animals Antioxidants - administration & dosage Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Drug Evaluation, Preclinical Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Male Oxidative Stress - drug effects Ramipril - administration & dosage Random Allocation Rats Simvastatin - administration & dosage Statistics, Nonparametric |
| title | Effects of ramipril and simvastatin on the oxidative stress of diabetic rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T17%3A01%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20ramipril%20and%20simvastatin%20on%20the%20oxidative%20stress%20of%20diabetic%20rats&rft.jtitle=Arquivos%20brasileiros%20de%20endocrinologia%20e%20metabologia&rft.au=Elias,%20Jos%C3%A9%20A%20Z&rft.date=2008-10&rft.volume=52&rft.issue=7&rft.spage=1131&rft.pages=1131-&rft.eissn=1677-9487&rft_id=info:doi/10.1590/S0004-27302008000700009&rft_dat=%3Cpubmed%3E19082301%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19082301&rfr_iscdi=true |