Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells

Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-gamma (IFNgamma)-stimulated dendritic cells (DCs). IDO has recently been established as a key enzyme in T-cell suppression-mediated immune tolerance t...

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Veröffentlicht in:	The Journal of biological chemistry 2009-02, Vol.284 (6), p.3700
Hauptverfasser:	Jeong, Young-Il, Kim, Sang Woo, Jung, In Duk, Lee, Jun Sik, Chang, Jeong Hyun, Lee, Chang-Min, Chun, Sung Hak, Yoon, Man-Soo, Kim, Geun Tae, Ryu, Seok Woo, Kim, Jong-Suk, Shin, Yong Kyoo, Lee, Won Suk, Shin, Hwa Kyoung, Lee, Jae-Dong, Park, Yeong-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Active Transport, Cell Nucleus - immunology Animals Bone Marrow Cells - enzymology Bone Marrow Cells - immunology Cell Nucleus - enzymology Cell Nucleus - immunology Cucumis - immunology Dendritic Cells - enzymology Dendritic Cells - immunology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology Immune Tolerance - drug effects Immune Tolerance - physiology Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology Interferon Regulatory Factor-1 - immunology Interferon Regulatory Factor-1 - metabolism Interferon-gamma - immunology Interferon-gamma - metabolism Interferon-gamma - pharmacology Janus Kinase 1 - immunology Janus Kinase 1 - metabolism Janus Kinase 2 - immunology Janus Kinase 2 - metabolism Mice Neoplasms - enzymology Neoplasms - immunology Phosphorylation - immunology Protein Kinase C-delta - immunology Protein Kinase C-delta - metabolism Response Elements - immunology STAT1 Transcription Factor - immunology STAT1 Transcription Factor - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism
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