Slow Recovery From Excitation of Thalamic Reticular Nucleus Neurons
1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2 Graduate University of Chinese Academy of Sciences, Beijing, China; 3 CAS-Hong Kong Joint Laboratory for Visuo-Auditory Integration, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloo...
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| Veröffentlicht in: | Journal of neurophysiology 2009-02, Vol.101 (2), p.980-987 |
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| container_title | Journal of neurophysiology |
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| creator | Yu, Xiong-Jie Xu, Xin-Xiu Chen, Xi He, Shigang He, Jufang |
| description | 1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2 Graduate University of Chinese Academy of Sciences, Beijing, China; 3 CAS-Hong Kong Joint Laboratory for Visuo-Auditory Integration, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
Submitted 9 October 2008;
accepted in final form 8 December 2008
Responses to repeated auditory stimuli were examined in 103 neurons in the auditory region of the thalamic reticular nucleus (TRN) and in 20 medial geniculate (MGB) neurons of anesthetized rats. A further six TRN neurons were recorded from awake rats. The TRN neurons showed strong responses to the first trial and weak responses to the subsequent trials of repeated auditory stimuli and electrical stimulation of the MGB and auditory cortex when the interstimulus interval (ISI) was short ( |
| doi_str_mv | 10.1152/jn.91130.2008 |
| format | Article |
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Submitted 9 October 2008;
accepted in final form 8 December 2008
Responses to repeated auditory stimuli were examined in 103 neurons in the auditory region of the thalamic reticular nucleus (TRN) and in 20 medial geniculate (MGB) neurons of anesthetized rats. A further six TRN neurons were recorded from awake rats. The TRN neurons showed strong responses to the first trial and weak responses to the subsequent trials of repeated auditory stimuli and electrical stimulation of the MGB and auditory cortex when the interstimulus interval (ISI) was short (<3 s). They responded to the second trial when the interstimulus interval was lengthened to 3 s. These responses contrasted to those of MGB neurons, which responded to repeated auditory stimuli of different ISIs. The TRN neurons showed a significant increase in the onset auditory response from 9.5 to 76.5 Hz when the ISI was increased from 200 ms to 10 s ( P < 0.001, ANOVA). The duration of the auditory-evoked oscillation was longer when the ISI was lengthened. The slow recovery of the TRN neurons after oscillation of burst firings to fast repetitive stimulus was a reflection of a different role than that of the thalamocortical relay neurons. Supposedly the TRN is involved in the process of attention such as attention shift; the slow recovery of TRN neurons probably limits the frequent change of the attention in a fast rhythm.
Address for reprint requests and other correspondence: J. He, Dept. of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (E-mail: rsjufang{at}polyu.edu.hk )</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.91130.2008</identifier><identifier>PMID: 19073800</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Acoustic Stimulation - methods ; Action Potentials - physiology ; Analysis of Variance ; Animals ; Auditory Cortex - physiology ; Auditory Pathways - physiology ; Electric Stimulation - methods ; Female ; Geniculate Bodies - cytology ; Intralaminar Thalamic Nuclei - cytology ; Male ; Neurons - physiology ; Rats ; Rats, Wistar ; Reaction Time - physiology</subject><ispartof>Journal of neurophysiology, 2009-02, Vol.101 (2), p.980-987</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-34d93b7f97ec9e3c8446bc3d4ad74289f019de2078e38df68a42f935a6c440fd3</citedby><cites>FETCH-LOGICAL-c433t-34d93b7f97ec9e3c8446bc3d4ad74289f019de2078e38df68a42f935a6c440fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3037,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19073800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Xiong-Jie</creatorcontrib><creatorcontrib>Xu, Xin-Xiu</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>He, Shigang</creatorcontrib><creatorcontrib>He, Jufang</creatorcontrib><title>Slow Recovery From Excitation of Thalamic Reticular Nucleus Neurons</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2 Graduate University of Chinese Academy of Sciences, Beijing, China; 3 CAS-Hong Kong Joint Laboratory for Visuo-Auditory Integration, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
Submitted 9 October 2008;
accepted in final form 8 December 2008
Responses to repeated auditory stimuli were examined in 103 neurons in the auditory region of the thalamic reticular nucleus (TRN) and in 20 medial geniculate (MGB) neurons of anesthetized rats. A further six TRN neurons were recorded from awake rats. The TRN neurons showed strong responses to the first trial and weak responses to the subsequent trials of repeated auditory stimuli and electrical stimulation of the MGB and auditory cortex when the interstimulus interval (ISI) was short (<3 s). They responded to the second trial when the interstimulus interval was lengthened to 3 s. These responses contrasted to those of MGB neurons, which responded to repeated auditory stimuli of different ISIs. The TRN neurons showed a significant increase in the onset auditory response from 9.5 to 76.5 Hz when the ISI was increased from 200 ms to 10 s ( P < 0.001, ANOVA). The duration of the auditory-evoked oscillation was longer when the ISI was lengthened. The slow recovery of the TRN neurons after oscillation of burst firings to fast repetitive stimulus was a reflection of a different role than that of the thalamocortical relay neurons. Supposedly the TRN is involved in the process of attention such as attention shift; the slow recovery of TRN neurons probably limits the frequent change of the attention in a fast rhythm.
Address for reprint requests and other correspondence: J. He, Dept. of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (E-mail: rsjufang{at}polyu.edu.hk )</description><subject>Acoustic Stimulation - methods</subject><subject>Action Potentials - physiology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Auditory Cortex - physiology</subject><subject>Auditory Pathways - physiology</subject><subject>Electric Stimulation - methods</subject><subject>Female</subject><subject>Geniculate Bodies - cytology</subject><subject>Intralaminar Thalamic Nuclei - cytology</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reaction Time - physiology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10D1PwzAQBmALgaB8jKwoE0wp59iN7RFVLSAhkKDMluvY1JUTFzsB-u9JaQUT051Oz73Di9A5hiHGo-J62QwFxgSGBQDfQ4P-VuR4JPg-GgD0OwHGjtBxSksAYCMoDtERFsAIBxig8YsPn9mz0eHDxHU2jaHOJl_atap1ocmCzWYL5VXtdI9apzuvYvbYaW-6lD2aLoYmnaIDq3wyZ7t5gl6nk9n4Ln94ur0f3zzkmhLS5oRWgsyZFcxoYYjmlJZzTSqqKkYLLixgUZkCGDeEV7bkihZWkJEqNaVgK3KCLre5qxjeO5NaWbukjfeqMaFLsiy5IJyxHuZbqGNIKRorV9HVKq4lBrlpTS4b-dOa3LTW-4tdcDevTfWndzX14GoLFu5t8emikavFOrngw9t6k4UBy0IKvpHkfzntvJ-Zr7Z_-f2Qq8qSbyATh9o</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Yu, Xiong-Jie</creator><creator>Xu, Xin-Xiu</creator><creator>Chen, Xi</creator><creator>He, Shigang</creator><creator>He, Jufang</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Slow Recovery From Excitation of Thalamic Reticular Nucleus Neurons</title><author>Yu, Xiong-Jie ; Xu, Xin-Xiu ; Chen, Xi ; He, Shigang ; He, Jufang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-34d93b7f97ec9e3c8446bc3d4ad74289f019de2078e38df68a42f935a6c440fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Action Potentials - physiology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Auditory Cortex - physiology</topic><topic>Auditory Pathways - physiology</topic><topic>Electric Stimulation - methods</topic><topic>Female</topic><topic>Geniculate Bodies - cytology</topic><topic>Intralaminar Thalamic Nuclei - cytology</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Xiong-Jie</creatorcontrib><creatorcontrib>Xu, Xin-Xiu</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>He, Shigang</creatorcontrib><creatorcontrib>He, Jufang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Xiong-Jie</au><au>Xu, Xin-Xiu</au><au>Chen, Xi</au><au>He, Shigang</au><au>He, Jufang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Slow Recovery From Excitation of Thalamic Reticular Nucleus Neurons</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>101</volume><issue>2</issue><spage>980</spage><epage>987</epage><pages>980-987</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2 Graduate University of Chinese Academy of Sciences, Beijing, China; 3 CAS-Hong Kong Joint Laboratory for Visuo-Auditory Integration, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
Submitted 9 October 2008;
accepted in final form 8 December 2008
Responses to repeated auditory stimuli were examined in 103 neurons in the auditory region of the thalamic reticular nucleus (TRN) and in 20 medial geniculate (MGB) neurons of anesthetized rats. A further six TRN neurons were recorded from awake rats. The TRN neurons showed strong responses to the first trial and weak responses to the subsequent trials of repeated auditory stimuli and electrical stimulation of the MGB and auditory cortex when the interstimulus interval (ISI) was short (<3 s). They responded to the second trial when the interstimulus interval was lengthened to 3 s. These responses contrasted to those of MGB neurons, which responded to repeated auditory stimuli of different ISIs. The TRN neurons showed a significant increase in the onset auditory response from 9.5 to 76.5 Hz when the ISI was increased from 200 ms to 10 s ( P < 0.001, ANOVA). The duration of the auditory-evoked oscillation was longer when the ISI was lengthened. The slow recovery of the TRN neurons after oscillation of burst firings to fast repetitive stimulus was a reflection of a different role than that of the thalamocortical relay neurons. Supposedly the TRN is involved in the process of attention such as attention shift; the slow recovery of TRN neurons probably limits the frequent change of the attention in a fast rhythm.
Address for reprint requests and other correspondence: J. He, Dept. of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (E-mail: rsjufang{at}polyu.edu.hk )</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>19073800</pmid><doi>10.1152/jn.91130.2008</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acoustic Stimulation - methods Action Potentials - physiology Analysis of Variance Animals Auditory Cortex - physiology Auditory Pathways - physiology Electric Stimulation - methods Female Geniculate Bodies - cytology Intralaminar Thalamic Nuclei - cytology Male Neurons - physiology Rats Rats, Wistar Reaction Time - physiology |
| title | Slow Recovery From Excitation of Thalamic Reticular Nucleus Neurons |
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