Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappaB and AP-1 mediated transcription activation and as potential anti-inflammatory agents

A series of 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives were designed and synthesized. Synthesized molecules were further evaluated for their inhibitory activity towards transcription factors NF-kappaB and AP-1 mediated transcriptional activation in a cell line based...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-05, Vol.44 (5), p.2184
Hauptverfasser:	Giri, Rajan S, Thaker, Hardik M, Giordano, Tony, Williams, Jill, Rogers, Donna, Sudersanam, Vasudevan, Vasu, Kamala K
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Drug Design Humans Inflammation - drug therapy Inhibitory Concentration 50 NF-kappa B - antagonists & inhibitors Quinazolinones - chemical synthesis Quinazolinones - pharmacology Structure-Activity Relationship Transcription Factor AP-1 - antagonists & inhibitors Transcriptional Activation - drug effects
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