TRP channels as emerging targets for pain therapeutics
Background: The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest...
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| Veröffentlicht in: | Expert opinion on therapeutic targets 2009-01, Vol.13 (1), p.69-81 |
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| container_title | Expert opinion on therapeutic targets |
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| creator | Broad, Lisa M Mogg, Adrian J Beattie, Ruth E Ogden, Ann-Marie Blanco, Maria-Jesus Bleakman, David |
| description | Background: The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics. Objective/methods: We review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets. Results/conclusions: Vanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets. |
| doi_str_mv | 10.1517/14728220802616620 |
| format | Article |
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The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics. Objective/methods: We review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets. Results/conclusions: Vanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets.</description><identifier>ISSN: 1472-8222</identifier><identifier>EISSN: 1744-7631</identifier><identifier>DOI: 10.1517/14728220802616620</identifier><identifier>PMID: 19063707</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Humans ; nociception ; pain ; Pain - drug therapy ; pain therapeutics ; thermo-TRP ; TRP channels ; TRPC Cation Channels - drug effects ; TRPC Cation Channels - physiology</subject><ispartof>Expert opinion on therapeutic targets, 2009-01, Vol.13 (1), p.69-81</ispartof><rights>Informa UK Ltd 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c3f2af5df4dd45a3a6602b334c899d13d7add51473a905b444202b20dadda2493</citedby><cites>FETCH-LOGICAL-c429t-c3f2af5df4dd45a3a6602b334c899d13d7add51473a905b444202b20dadda2493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1517/14728220802616620$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1517/14728220802616620$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19063707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broad, Lisa M</creatorcontrib><creatorcontrib>Mogg, Adrian J</creatorcontrib><creatorcontrib>Beattie, Ruth E</creatorcontrib><creatorcontrib>Ogden, Ann-Marie</creatorcontrib><creatorcontrib>Blanco, Maria-Jesus</creatorcontrib><creatorcontrib>Bleakman, David</creatorcontrib><title>TRP channels as emerging targets for pain therapeutics</title><title>Expert opinion on therapeutic targets</title><addtitle>Expert Opin Ther Targets</addtitle><description>Background: The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics. Objective/methods: We review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets. Results/conclusions: Vanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets.</description><subject>Animals</subject><subject>Humans</subject><subject>nociception</subject><subject>pain</subject><subject>Pain - drug therapy</subject><subject>pain therapeutics</subject><subject>thermo-TRP</subject><subject>TRP channels</subject><subject>TRPC Cation Channels - drug effects</subject><subject>TRPC Cation Channels - physiology</subject><issn>1472-8222</issn><issn>1744-7631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoVqs_wIvsydtqvjbpohcpfkFBkXoO0yTb3bKbrUkW6b830oKI0NMMM-_7MvMgdEHwNSmIvCFc0gmleIKpIEJQfIBOiOQ8l4KRw9SnfZ4EdIROQ1hhTHFZiGM0IiUWTGJ5gsT8_S3TNThn25BByGxn_bJxyyyCX9oYsqr32Roal8XaeljbITY6nKGjCtpgz3d1jD4eH-bT53z2-vQyvZ_lmtMy5ppVFKrCVNwYXgADITBdMMb1pCwNYUaCMUU6k0GJiwXnnKY9xSaNgfKSjdHVNnft-8_Bhqi6JmjbtuBsPwQlhGScp2fGiGyF2vcheFuptW868BtFsPqBpf7BSp7LXfiw6Kz5dezoJMHdVtC4RKGDr963RkXYtL2vPDjdBMX25d_-sdcW2lhr8Fat-sG7BG7Pdd9REYig</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Broad, Lisa M</creator><creator>Mogg, Adrian J</creator><creator>Beattie, Ruth E</creator><creator>Ogden, Ann-Marie</creator><creator>Blanco, Maria-Jesus</creator><creator>Bleakman, David</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>TRP channels as emerging targets for pain therapeutics</title><author>Broad, Lisa M ; Mogg, Adrian J ; Beattie, Ruth E ; Ogden, Ann-Marie ; Blanco, Maria-Jesus ; Bleakman, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-c3f2af5df4dd45a3a6602b334c899d13d7add51473a905b444202b20dadda2493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Humans</topic><topic>nociception</topic><topic>pain</topic><topic>Pain - drug therapy</topic><topic>pain therapeutics</topic><topic>thermo-TRP</topic><topic>TRP channels</topic><topic>TRPC Cation Channels - drug effects</topic><topic>TRPC Cation Channels - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broad, Lisa M</creatorcontrib><creatorcontrib>Mogg, Adrian J</creatorcontrib><creatorcontrib>Beattie, Ruth E</creatorcontrib><creatorcontrib>Ogden, Ann-Marie</creatorcontrib><creatorcontrib>Blanco, Maria-Jesus</creatorcontrib><creatorcontrib>Bleakman, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Expert opinion on therapeutic targets</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broad, Lisa M</au><au>Mogg, Adrian J</au><au>Beattie, Ruth E</au><au>Ogden, Ann-Marie</au><au>Blanco, Maria-Jesus</au><au>Bleakman, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRP channels as emerging targets for pain therapeutics</atitle><jtitle>Expert opinion on therapeutic targets</jtitle><addtitle>Expert Opin Ther Targets</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>13</volume><issue>1</issue><spage>69</spage><epage>81</epage><pages>69-81</pages><issn>1472-8222</issn><eissn>1744-7631</eissn><abstract>Background: The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics. Objective/methods: We review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets. Results/conclusions: Vanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19063707</pmid><doi>10.1517/14728220802616620</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1472-8222 |
| ispartof | Expert opinion on therapeutic targets, 2009-01, Vol.13 (1), p.69-81 |
| issn | 1472-8222 1744-7631 |
| language | eng |
| recordid | cdi_pubmed_primary_19063707 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Humans nociception pain Pain - drug therapy pain therapeutics thermo-TRP TRP channels TRPC Cation Channels - drug effects TRPC Cation Channels - physiology |
| title | TRP channels as emerging targets for pain therapeutics |
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