Bile Acids Metabonomic Study on the CCl4- and α-Naphthylisothiocyanate-Induced Animal Models: Quantitative Analysis of 22 Bile Acids by Ultraperformance Liquid Chromatography−Mass Spectrometry

Bile acids (BAs) are crucial for the diagnosis, follow-up, and prognostics of liver and intestinal disorders and other diseases affecting BA metabolism. A rapid, simple, and sensitive analytical method is needed to demonstrate the full metabolic profile and simultaneously determine the individual BA...

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Veröffentlicht in:	Chemical research in toxicology 2008-12, Vol.21 (12), p.2280-2288
Hauptverfasser:	Yang, Li, Xiong, Aizhen, He, Yuqi, Wang, Zaiyong, Wang, Changhong, Wang, Zhengtao, Li, Wei, Yang, Ling, Hu, Zhibi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylisothiocyanate - metabolism 1-Naphthylisothiocyanate - toxicity Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Bile Acids and Salts - metabolism Carbon Tetrachloride - metabolism Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chromatography, High Pressure Liquid - methods Discriminant Analysis Disease Models, Animal Liver - drug effects Liver - metabolism Liver Failure - etiology Liver Failure - metabolism Male Metabolomics Principal Component Analysis Rats Rats, Sprague-Dawley Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods
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