Identifying critical residues in protein folding: Insights from phi-value and P(fold) analysis

We apply a simulational proxy of the phi-value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding "reactions" of two small lattice Go polymers with different native geometries. Our findings show that for the more complex native fold (i...

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Veröffentlicht in:	The Journal of chemical physics 2008-09, Vol.129 (9), p.095108
Hauptverfasser:	Faísca, P F N, Travasso, R D M, Ball, R C, Shakhnovich, E I
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Models, Chemical Mutagenesis, Site-Directed Protein Folding Proteins - chemistry Proteins - genetics Proteins - metabolism
Online-Zugang:	Volltext
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