CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production

T helper 2 (Th2) cells are critical to the induction of IgE antibody and allergic inflammation, but how the pathological pathways are controlled in nonallergic individuals remains unclear. Here we report that glycosylation-inhibiting factor (GIF) suppresses Th2 effector generation. GIF is a cytokine...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (49), p.19402-19407
Hauptverfasser:	Kim-Saijo, Misa, Janssen, Edith M, Sugie, Katsuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals B lymphocytes Biological Sciences Bone marrow cells Bone Marrow Transplantation CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Communication - immunology Cell Differentiation - immunology Cell nucleus Cells, Cultured Cytokines Dendritic Cells - cytology Dendritic Cells - immunology Forkhead Transcription Factors - metabolism Hypersensitivity - immunology Inflammation Interleukin-2 Receptor alpha Subunit - metabolism Interleukin-4 - genetics Interleukin-4 - metabolism Lymph Nodes - cytology Lymphokines - genetics Lymphokines - immunology Lymphokines - metabolism Macrophages Messenger RNA Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Mutant Strains NFATC Transcription Factors - metabolism Ova Protein Processing, Post-Translational - immunology RNA, Messenger - metabolism Spleen - cytology T lymphocytes T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th2 Cells - cytology Th2 Cells - immunology Th2 Cells - metabolism
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