In vivo imaging of vesicular monoamine transporter 2 in pancreas using an (18)F epoxide derivative of tetrabenazine

Development of imaging agents for pancreatic beta cell mass may provide tools for studying insulin-secreting beta cells and their relationship with diabetes mellitus. In this paper, a new imaging agent, [(18)F](+)-2-oxiranyl-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido...

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Veröffentlicht in:	Nuclear medicine and biology 2008-11, Vol.35 (8), p.825
Hauptverfasser:	Kung, Hank F, Lieberman, Brian P, Zhuang, Zhi-Ping, Oya, Shunichi, Kung, Mei-Ping, Choi, Seok Rye, Poessl, Karl, Blankemeyer, Eric, Hou, Catherine, Skovronsky, Daniel, Kilbourn, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Fluorine Radioisotopes Insulin-Secreting Cells - diagnostic imaging Insulin-Secreting Cells - metabolism Male Positron-Emission Tomography Radiopharmaceuticals - metabolism Rats Rats, Sprague-Dawley Tetrabenazine - analogs & derivatives Tissue Distribution Vesicular Monoamine Transport Proteins - metabolism
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