The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation

Prostaglandin D(2) activation of the seven-transmembrane receptor CRTH2 regulates numerous cell functions that are important in inflammatory diseases, such as asthma. Despite its disease implication, no studies to date aimed at identifying receptor domains governing signaling and surface expression...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2009-01, Vol.284 (2), p.1324
Hauptverfasser:	Schröder, Ralf, Merten, Nicole, Mathiesen, Jesper Mosolff, Martini, Lene, Kruljac-Letunic, Anamarija, Krop, Friederike, Blaukat, Andree, Fang, Ye, Tran, Elizabeth, Ulven, Trond, Drewke, Christel, Whistler, Jennifer, Pardo, Leonardo, Gomeza, Jesús, Kostenis, Evi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arrestins - metabolism beta-Arrestins Cell Line Cyclic AMP - metabolism ErbB Receptors - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Humans Molecular Sequence Data Phosphorylation Prostaglandin D2 - pharmacology Protein Binding Receptors, Immunologic - chemistry Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Prostaglandin - chemistry Receptors, Prostaglandin - genetics Receptors, Prostaglandin - metabolism Sequence Alignment Signal Transduction Substrate Specificity Time Factors Transcriptional Activation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!