Altered pore properties and kinetic changes in mutants of the Vibrio cholerae Porin OmpU

The electrophysiological technique of patch-clamp was used to characterize the pore properties of site-directed mutants in the Vibrio cholerae general diffusion porin OmpU. Changes in conductance and selectivity were observed, thus confirming the predicted pore location of these residues, based on h...

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Veröffentlicht in:	Molecular membrane biology 2008-01, Vol.25 (6-7), p.498-505
Hauptverfasser:	Lauman, Brian, Pagel, Melissa, Delcour, Anne H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - genetics Adhesins, Bacterial - pharmacology bacteria beta-Lactam Resistance channel Deoxycholic Acid - pharmacology Electrophysiology Kinetics Mutagenesis, Site-Directed mutant Mutation patch-clamp Patch-Clamp Techniques Permeability - drug effects Polysaccharides - pharmacology Porin Porosity Vibrio cholerae - chemistry Vibrio cholerae - pathogenicity
Online-Zugang:	Volltext
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