Weak Functional Coupling of the Melanocortin-1 Receptor Expressed in Human Adipocytes

The melanocortin (MC) receptor type-1 (MC1-R) is the only one of the five MC receptor subtypes expressed in human adipose tissue explants, human mesenchymal stem cells (MSCs), and MSC-derived adipocytes. Following our recent expression studies (Obesity 2007, 15, 40-49), we now investigated the funct...

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Veröffentlicht in:	Journal of receptors and signal transduction 2008-01, Vol.28 (5), p.485-504
Hauptverfasser:	Hoch, Matthias, Hirzel, Estelle, Lindinger, Peter, Eberle, Alex N., Linscheid, Philippe, Martin, Ivan, Peters, Thomas, Peterli, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocyte Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adolescent Adult Affinity Labels - pharmacology alpha-MSH - analogs & derivatives alpha-MSH - pharmacology Anticarcinogenic Agents - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Humans IL-6 Interleukin-10 - metabolism Interleukin-6 - metabolism Interleukin-8 - drug effects Interleukin-8 - metabolism Lipolysis - drug effects MC1-R Mesenchymal stem cell Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Middle Aged NDP-MSH Receptor, Melanocortin, Type 1 - drug effects Receptor, Melanocortin, Type 1 - metabolism Signal Transduction TNF-α Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism Young Adult
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