Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-kappaB/interleukin-6 pathway

Stromal cell-derived factor 1alpha (SDF-1alpha) (CXCL12) has been observed to enhance tumor angiogenesis. However, the comprehensive role of SDF-1alpha (CXCL12)-CXCR4 interaction, exerted during angiogenesis, has not been well understood. We have previously demonstrated that human basal cell carcino...

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Veröffentlicht in:	Carcinogenesis (New York) 2009-02, Vol.30 (2), p.205
Hauptverfasser:	Chu, Chia-Yu, Cha, Shih-Ting, Lin, Wan-Chi, Lu, Po-Hsuan, Tan, Ching-Ting, Chang, Cheng-Chi, Lin, Ben-Ren, Jee, Shiou-Hwa, Kuo, Min-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - metabolism Carcinoma, Basal Cell - blood supply Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Cell Line, Tumor Chemokine CXCL12 - physiology Humans Interleukin-6 - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology NF-kappa B - metabolism Phosphorylation Receptors, CXCR4 - metabolism Skin Neoplasms - blood supply Skin Neoplasms - metabolism Skin Neoplasms - pathology Up-Regulation
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