Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats
Effect of methanolic extract of fruits of P. longum (PLM) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (ADR) induced cardiotoxicity in Wistar rats was investigated. PLM was administered to Wistar albino rats in two different doses, by gastric g...
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| Veröffentlicht in: | Indian journal of experimental biology 2008-07, Vol.46 (7), p.528 |
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| creator | Wakade, Alok S Shah, Abhishek S Kulkarni, Mrugaya P Juvekar, Archana R |
| description | Effect of methanolic extract of fruits of P. longum (PLM) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (ADR) induced cardiotoxicity in Wistar rats was investigated. PLM was administered to Wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip ADR (15 mg/kg) on 21st day. ADR administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanine transaminase, lactate dehydrogenase and creatine kinase in heart with a concomitant increase in their activities in serum. A significant increase in lipid peroxide levels in heart of ADR treated rats was also observed. Pretreatment with PLM ameliorated the effect of ADR on lipid peroxide formation and restored activities of marker enzymes. Activities of myocardial antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase along with reduced glutathione were significantly lowered due to cardiotoxicity in rats administered with ADR. PLM pretreatment augmented these endogenous antioxidants. Histopathological studies of heart revealed degenerative changes and cellular infiltrations in rats administered with ADR and pretreatment with PLM reduced the intensity of such lesions. The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity. |
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PLM was administered to Wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip ADR (15 mg/kg) on 21st day. ADR administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanine transaminase, lactate dehydrogenase and creatine kinase in heart with a concomitant increase in their activities in serum. A significant increase in lipid peroxide levels in heart of ADR treated rats was also observed. Pretreatment with PLM ameliorated the effect of ADR on lipid peroxide formation and restored activities of marker enzymes. Activities of myocardial antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase along with reduced glutathione were significantly lowered due to cardiotoxicity in rats administered with ADR. PLM pretreatment augmented these endogenous antioxidants. Histopathological studies of heart revealed degenerative changes and cellular infiltrations in rats administered with ADR and pretreatment with PLM reduced the intensity of such lesions. The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity.</description><identifier>ISSN: 0019-5189</identifier><identifier>PMID: 18807757</identifier><language>eng</language><publisher>India</publisher><subject>Animals ; Biomarkers - metabolism ; Doxorubicin - pharmacology ; Doxorubicin - toxicity ; Glutathione - metabolism ; Heart Diseases - chemically induced ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Heart Diseases - prevention & control ; Male ; Malondialdehyde - metabolism ; Oxidative Stress - drug effects ; Phytotherapy ; Piper - chemistry ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar</subject><ispartof>Indian journal of experimental biology, 2008-07, Vol.46 (7), p.528</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18807757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wakade, Alok S</creatorcontrib><creatorcontrib>Shah, Abhishek S</creatorcontrib><creatorcontrib>Kulkarni, Mrugaya P</creatorcontrib><creatorcontrib>Juvekar, Archana R</creatorcontrib><title>Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats</title><title>Indian journal of experimental biology</title><addtitle>Indian J Exp Biol</addtitle><description>Effect of methanolic extract of fruits of P. longum (PLM) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (ADR) induced cardiotoxicity in Wistar rats was investigated. PLM was administered to Wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip ADR (15 mg/kg) on 21st day. ADR administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanine transaminase, lactate dehydrogenase and creatine kinase in heart with a concomitant increase in their activities in serum. A significant increase in lipid peroxide levels in heart of ADR treated rats was also observed. Pretreatment with PLM ameliorated the effect of ADR on lipid peroxide formation and restored activities of marker enzymes. Activities of myocardial antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase along with reduced glutathione were significantly lowered due to cardiotoxicity in rats administered with ADR. PLM pretreatment augmented these endogenous antioxidants. Histopathological studies of heart revealed degenerative changes and cellular infiltrations in rats administered with ADR and pretreatment with PLM reduced the intensity of such lesions. The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity.</description><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Doxorubicin - pharmacology</subject><subject>Doxorubicin - toxicity</subject><subject>Glutathione - metabolism</subject><subject>Heart Diseases - chemically induced</subject><subject>Heart Diseases - metabolism</subject><subject>Heart Diseases - pathology</subject><subject>Heart Diseases - prevention & control</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Piper - chemistry</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0019-5189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UEtOwzAU9AJES-EKyBcIsp04jpeo4idVogtYVy_-IFdOHNkOIofgzljQrmY0v8VcoDUhVFacdnKFrlM6EtJyKckVWtGuI0JwsUY_-xiyUdl9GWysLQwHi_duMhH7MH7OA97d4zDi8O00_MVSjiYl7EY9K6MLHue4YBg1Vsb72UPE0I8hDuBdXoqPQUcHw6IKPbcURO1CLqvqFIqQ0w26tOCTuT3hBn08Pb5vX6rd2_Pr9mFXTYzIXLVKtITRVjMOLROS1wKAULCkabQyFIqtdMcUNdBIKrRtdBFFx0nPmFL1Bt39705zPxh9mKIbIC6H8y_1L8MDYWQ</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Wakade, Alok S</creator><creator>Shah, Abhishek S</creator><creator>Kulkarni, Mrugaya P</creator><creator>Juvekar, Archana R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200807</creationdate><title>Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats</title><author>Wakade, Alok S ; Shah, Abhishek S ; Kulkarni, Mrugaya P ; Juvekar, Archana R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-6c760216d25a6279537aa01af044dce1a760cd82c1ea4917df4d1a77850b22cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biomarkers - metabolism</topic><topic>Doxorubicin - pharmacology</topic><topic>Doxorubicin - toxicity</topic><topic>Glutathione - metabolism</topic><topic>Heart Diseases - chemically induced</topic><topic>Heart Diseases - metabolism</topic><topic>Heart Diseases - pathology</topic><topic>Heart Diseases - prevention & control</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy</topic><topic>Piper - chemistry</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wakade, Alok S</creatorcontrib><creatorcontrib>Shah, Abhishek S</creatorcontrib><creatorcontrib>Kulkarni, Mrugaya P</creatorcontrib><creatorcontrib>Juvekar, Archana R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Indian journal of experimental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakade, Alok S</au><au>Shah, Abhishek S</au><au>Kulkarni, Mrugaya P</au><au>Juvekar, Archana R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats</atitle><jtitle>Indian journal of experimental biology</jtitle><addtitle>Indian J Exp Biol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>46</volume><issue>7</issue><spage>528</spage><pages>528-</pages><issn>0019-5189</issn><abstract>Effect of methanolic extract of fruits of P. longum (PLM) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (ADR) induced cardiotoxicity in Wistar rats was investigated. PLM was administered to Wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip ADR (15 mg/kg) on 21st day. ADR administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanine transaminase, lactate dehydrogenase and creatine kinase in heart with a concomitant increase in their activities in serum. A significant increase in lipid peroxide levels in heart of ADR treated rats was also observed. Pretreatment with PLM ameliorated the effect of ADR on lipid peroxide formation and restored activities of marker enzymes. Activities of myocardial antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase along with reduced glutathione were significantly lowered due to cardiotoxicity in rats administered with ADR. PLM pretreatment augmented these endogenous antioxidants. Histopathological studies of heart revealed degenerative changes and cellular infiltrations in rats administered with ADR and pretreatment with PLM reduced the intensity of such lesions. The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity.</abstract><cop>India</cop><pmid>18807757</pmid></addata></record> |
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| subjects | Animals Biomarkers - metabolism Doxorubicin - pharmacology Doxorubicin - toxicity Glutathione - metabolism Heart Diseases - chemically induced Heart Diseases - metabolism Heart Diseases - pathology Heart Diseases - prevention & control Male Malondialdehyde - metabolism Oxidative Stress - drug effects Phytotherapy Piper - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Rats Rats, Wistar |
| title | Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats |
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