In vivo positron emission tomography (PET) imaging with an alphavbeta6 specific peptide radiolabeled using 18F-"click" chemistry: evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F]fluoropropionyl-peptides

Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [(18)F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-phase (18)F-"click" radiolabeling and sol...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-10, Vol.51 (19), p.5901
Hauptverfasser:	Hausner, Sven H, Marik, Jan, Gagnon, M Karen J, Sutcliffe, Julie L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - chemistry Antigens, Neoplasm - drug effects Antigens, Neoplasm - metabolism Benzoates - chemistry Cell Line, Tumor Fluorine Radioisotopes Humans Integrins - chemistry Integrins - drug effects Integrins - metabolism Male Mice Mice, Nude Molecular Structure Neoplasms - diagnosis Peptides - chemistry Peptides - pharmacokinetics Positron-Emission Tomography - methods Propionates - chemistry Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Sensitivity and Specificity Stereoisomerism Tissue Distribution Xenograft Model Antitumor Assays
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