Fine Structure of Pancreatic Adenocarcinoma Induced In Rats by 7,12-Dimethylbenz[a]anthracene

We induced pancreatic adenocarcinomas in LongEvans rats by placing crystals, 2–3 mg, of 7, 12-dimethylbenz[a]anthracene (DMBA) in a 2- to 3-mm incision in the “head” of the pancreas approximately 1 cm from the duodenum. The incisions were closed with one or two silk sutures. The animals were killed...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1976-10, Vol.57 (4), p.931-936
Hauptverfasser:	Bockman, Dale E., Black, Owen, Mills, Luther R., Mainz, David L., Webster, Paul D.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - administration & dosage Adenocarcinoma - chemically induced Adenocarcinoma - ultrastructure Animals Benz(a)Anthracenes Carcinoma - etiology Carcinoma, Intraductal, Noninfiltrating - etiology Cell Nucleus - ultrastructure Disease Models, Animal Drug Implants Endoplasmic Reticulum - ultrastructure Female Golgi Apparatus - ultrastructure Male Neoplasms, Experimental - chemically induced Neoplasms, Experimental - ultrastructure Pancreatic Neoplasms - chemically induced Pancreatic Neoplasms - etiology Pancreatic Neoplasms - ultrastructure Rats
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