Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice

Department of Exercise Science, Skidmore College, Saratoga Springs, New York Submitted 16 May 2008 ; accepted in final form 25 August 2008 Studies of cultured cells have indicated that the mammalian target of rapamycin complex 1 (mTORC1) mediates the development of insulin resistance. Because a role...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2008-11, Vol.295 (5), p.R1431-R1438
Hauptverfasser:	Miller, Andrew M, Brestoff, Jonathan R, Phelps, Charles B, Berk, E. Zachary, Reynolds, Thomas H., IV
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Blood Glucose - metabolism Body Weight - drug effects Body Weight - physiology Cell culture Drugs Electrophoresis, Polyacrylamide Gel Endocrine Physiology and Metabolism Glucose Tolerance Test Insulin Insulin - physiology Insulin Receptor Substrate Proteins - biosynthesis Insulin Receptor Substrate Proteins - genetics Insulin Resistance - physiology Male Mammals Mice Mice, Obese Muscle, Skeletal - physiology Musculoskeletal system Phosphoproteins - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - metabolism Rodents Signal transduction Sirolimus - pharmacology Transcription Factors - biosynthesis Transcription Factors - physiology
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