Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits

: The aim of this study was to investigate the hypotensive effect of the melatonin analogue, N‐butanoyl‐2‐(2‐methoxy‐6H‐isoindolo[2,1‐a]indol‐11‐yl)ethanamine (IIK7), through MT2‐melatonin receptors and the involvement of the sympathetic nervous system in this action in New Zealand rabbit eyes. The...

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Veröffentlicht in:	Journal of pineal research 2008-11, Vol.45 (4), p.468-475
Hauptverfasser:	Alarma-Estrany, Pilar, Crooke, Almudena, Mediero, Aránzazu, Peláez, Teresa, Pintor, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine Administration, Topical Adrenergic beta-Agonists - pharmacology Albuterol - pharmacology Animals Aqueous Humor - physiology Biological and medical sciences Colforsin - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology IIK7 Intraocular pressure Intraocular Pressure - drug effects Isoindoles - pharmacology melatonin Melatonin - analogs & derivatives Melatonin - pharmacology MT2-melatonin receptors Ocular Hypertension - drug therapy Ocular Hypertension - metabolism Okadaic Acid - pharmacology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rabbits Receptor, Melatonin, MT2 - agonists Receptor, Melatonin, MT2 - antagonists & inhibitors Receptor, Melatonin, MT2 - physiology Sympathectomy, Chemical sympathethic nervous system Sympathetic Nervous System - physiology Terbutaline - pharmacology Vertebrates: endocrinology Vertebrates: nervous system and sense organs
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