Transition State for Protein: DNA Recognition

We describe the formation of protein-DNA contacts in the two-state route for DNA sequence recognition by a transcriptional regulator. Surprisingly, direct sequence readout establishes in the transition state and constitutes the bottleneck of complex formation. Although a few nonspecific ionic intera...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-08, Vol.105 (31), p.10797-10802
Hauptverfasser:	Ferreiro, Diego U., Sánchez, Ignacio E., de Prat Gay, Gonzalo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bending Binding sites Biological Sciences Deoxyribonucleic acid DNA DNA - metabolism Genetic equilibrium Genetic mutation Kinetics Models, Molecular Molecules Oligonucleotides Papillomaviridae - metabolism Protein Binding Proteins Reagents Thermodynamic equilibrium Thermodynamics Transcription Factors - metabolism Viral Envelope Proteins - metabolism
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