Carcinogenic Effects of Intragastric 3-Methylcholanthrene and 7,12-Dimethylbenz[a]anthracene in Wistar and Sprague-Dawley Rats
In 2 experiments involving 384 rats of the Wistar (W) and Sprague-Dawley (SD) strains, the carcinogenic effects of repeated intragastric instillations of 3-methylcholanthrene (MCA) were compared with those of single intragastric doses of 7,12-dimethylbenz[a]anthracene (DMBA). Mammary carcinomas appe...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1966-03, Vol.36 (3), p.483-502 |
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| creator | Gruenstein, M. Meranze, D. R. Thatcher, D. Shimkin, M. B. |
| description | In 2 experiments involving 384 rats of the Wistar (W) and Sprague-Dawley (SD) strains, the carcinogenic effects of repeated intragastric instillations of 3-methylcholanthrene (MCA) were compared with those of single intragastric doses of 7,12-dimethylbenz[a]anthracene (DMBA). Mammary carcinomas appeared in a higher proportion and earlier in SO than in W rats exposed to either carcinogen (during 36 weeks, 90 vs. 50% with MCA in SD and W rats, at an average of 12 and 15 weeks, respectively, and 80 vs. 64% with DMBA in SO and W rats, at an average of 16 and 22 weeks, respectively). Fibroadenomas of the breast were seen in 20 percent of SD rats by 36 weeks. In W rats observed for 1 year following DMBA administration, fibroadenomas occurred in 64 percent and adenosis in 49 percent, at an average of 45 to 51 weeks, whereas after MCA administration these reactions occurred in less than 10 percent. Intraluminal secretion indicative of lactation was noted in approximately 20 percent of Fibroadenomas and adenoses. Nine W rats developed lymphoma, 5 following DMBA and 4 following MCA administration. Uterine papillary formations were observed in 1 W and 2 SD rats, and uterine carcinomas in 2 SD rats; 3 animals had received DMBA and 2, MCA. |
| doi_str_mv | 10.1093/jnci/36.3.483 |
| format | Article |
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R. ; Thatcher, D. ; Shimkin, M. B.</creator><creatorcontrib>Gruenstein, M. ; Meranze, D. R. ; Thatcher, D. ; Shimkin, M. B.</creatorcontrib><description>In 2 experiments involving 384 rats of the Wistar (W) and Sprague-Dawley (SD) strains, the carcinogenic effects of repeated intragastric instillations of 3-methylcholanthrene (MCA) were compared with those of single intragastric doses of 7,12-dimethylbenz[a]anthracene (DMBA). Mammary carcinomas appeared in a higher proportion and earlier in SO than in W rats exposed to either carcinogen (during 36 weeks, 90 vs. 50% with MCA in SD and W rats, at an average of 12 and 15 weeks, respectively, and 80 vs. 64% with DMBA in SO and W rats, at an average of 16 and 22 weeks, respectively). Fibroadenomas of the breast were seen in 20 percent of SD rats by 36 weeks. In W rats observed for 1 year following DMBA administration, fibroadenomas occurred in 64 percent and adenosis in 49 percent, at an average of 45 to 51 weeks, whereas after MCA administration these reactions occurred in less than 10 percent. Intraluminal secretion indicative of lactation was noted in approximately 20 percent of Fibroadenomas and adenoses. Nine W rats developed lymphoma, 5 following DMBA and 4 following MCA administration. Uterine papillary formations were observed in 1 W and 2 SD rats, and uterine carcinomas in 2 SD rats; 3 animals had received DMBA and 2, MCA.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/36.3.483</identifier><identifier>PMID: 18630323</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage ; 9,10-Dimethyl-1,2-benzanthracene - toxicity ; Animals ; Carcinogens - administration & dosage ; Carcinogens - toxicity ; Female ; Fibroadenoma - chemically induced ; Fibroadenoma - pathology ; Fibrocystic Breast Disease - chemically induced ; Fibrocystic Breast Disease - pathology ; Male ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - pathology ; Methylcholanthrene - administration & dosage ; Methylcholanthrene - toxicity ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Stomach ; Time Factors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1966-03, Vol.36 (3), p.483-502</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18630323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruenstein, M.</creatorcontrib><creatorcontrib>Meranze, D. R.</creatorcontrib><creatorcontrib>Thatcher, D.</creatorcontrib><creatorcontrib>Shimkin, M. B.</creatorcontrib><title>Carcinogenic Effects of Intragastric 3-Methylcholanthrene and 7,12-Dimethylbenz[a]anthracene in Wistar and Sprague-Dawley Rats</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>In 2 experiments involving 384 rats of the Wistar (W) and Sprague-Dawley (SD) strains, the carcinogenic effects of repeated intragastric instillations of 3-methylcholanthrene (MCA) were compared with those of single intragastric doses of 7,12-dimethylbenz[a]anthracene (DMBA). Mammary carcinomas appeared in a higher proportion and earlier in SO than in W rats exposed to either carcinogen (during 36 weeks, 90 vs. 50% with MCA in SD and W rats, at an average of 12 and 15 weeks, respectively, and 80 vs. 64% with DMBA in SO and W rats, at an average of 16 and 22 weeks, respectively). Fibroadenomas of the breast were seen in 20 percent of SD rats by 36 weeks. In W rats observed for 1 year following DMBA administration, fibroadenomas occurred in 64 percent and adenosis in 49 percent, at an average of 45 to 51 weeks, whereas after MCA administration these reactions occurred in less than 10 percent. Intraluminal secretion indicative of lactation was noted in approximately 20 percent of Fibroadenomas and adenoses. Nine W rats developed lymphoma, 5 following DMBA and 4 following MCA administration. Uterine papillary formations were observed in 1 W and 2 SD rats, and uterine carcinomas in 2 SD rats; 3 animals had received DMBA and 2, MCA.</description><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</subject><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Animals</subject><subject>Carcinogens - administration & dosage</subject><subject>Carcinogens - toxicity</subject><subject>Female</subject><subject>Fibroadenoma - chemically induced</subject><subject>Fibroadenoma - pathology</subject><subject>Fibrocystic Breast Disease - chemically induced</subject><subject>Fibrocystic Breast Disease - pathology</subject><subject>Male</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Methylcholanthrene - administration & dosage</subject><subject>Methylcholanthrene - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>Stomach</subject><subject>Time Factors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OAjEUhRujEUSXbs08gIVO2-nPUgEFxZiARqIxk85MB4pQSKdEceGzW0G9m5vc8-XkngPAaYyaMZKkNbO5aRHWJE0qyB6ox5QhiGOU7IM6QphDITitgaOqmqEwEtNDUIsFI4hgUgdfbeVyY5cTbU0edctS576KlmXUt96piaq8C3cC77Sfbub5dDlX1k-dtjpStoj4eYxhxyy2aqbt54t63QIq_0GMjZ5M5ZXbwqNVcFxr2FHvc72JhspXx-CgVPNKn_zuBni86j60e3Bwf91vXwygwTTxIYMgFCOmQwKuJZWIEVlkBWKYUJ1lipRUcCQEypmQklKNC8oLTFgpExzkBjjb-a7W2UIX6cqZhXKb9K-IAMAdEN7VH_-6cm8p44QnaW_8nN4m45vh5QinlHwDN35vSw</recordid><startdate>196603</startdate><enddate>196603</enddate><creator>Gruenstein, M.</creator><creator>Meranze, D. 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B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i245t-88834206e0007e9490639dbd06234ebba3f4870880c689944e2d47d236f952ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</topic><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Animals</topic><topic>Carcinogens - administration & dosage</topic><topic>Carcinogens - toxicity</topic><topic>Female</topic><topic>Fibroadenoma - chemically induced</topic><topic>Fibroadenoma - pathology</topic><topic>Fibrocystic Breast Disease - chemically induced</topic><topic>Fibrocystic Breast Disease - pathology</topic><topic>Male</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>Methylcholanthrene - administration & dosage</topic><topic>Methylcholanthrene - toxicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>Stomach</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruenstein, M.</creatorcontrib><creatorcontrib>Meranze, D. R.</creatorcontrib><creatorcontrib>Thatcher, D.</creatorcontrib><creatorcontrib>Shimkin, M. B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruenstein, M.</au><au>Meranze, D. R.</au><au>Thatcher, D.</au><au>Shimkin, M. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinogenic Effects of Intragastric 3-Methylcholanthrene and 7,12-Dimethylbenz[a]anthracene in Wistar and Sprague-Dawley Rats</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1966-03</date><risdate>1966</risdate><volume>36</volume><issue>3</issue><spage>483</spage><epage>502</epage><pages>483-502</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>In 2 experiments involving 384 rats of the Wistar (W) and Sprague-Dawley (SD) strains, the carcinogenic effects of repeated intragastric instillations of 3-methylcholanthrene (MCA) were compared with those of single intragastric doses of 7,12-dimethylbenz[a]anthracene (DMBA). Mammary carcinomas appeared in a higher proportion and earlier in SO than in W rats exposed to either carcinogen (during 36 weeks, 90 vs. 50% with MCA in SD and W rats, at an average of 12 and 15 weeks, respectively, and 80 vs. 64% with DMBA in SO and W rats, at an average of 16 and 22 weeks, respectively). Fibroadenomas of the breast were seen in 20 percent of SD rats by 36 weeks. In W rats observed for 1 year following DMBA administration, fibroadenomas occurred in 64 percent and adenosis in 49 percent, at an average of 45 to 51 weeks, whereas after MCA administration these reactions occurred in less than 10 percent. Intraluminal secretion indicative of lactation was noted in approximately 20 percent of Fibroadenomas and adenoses. Nine W rats developed lymphoma, 5 following DMBA and 4 following MCA administration. Uterine papillary formations were observed in 1 W and 2 SD rats, and uterine carcinomas in 2 SD rats; 3 animals had received DMBA and 2, MCA.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>18630323</pmid><doi>10.1093/jnci/36.3.483</doi><tpages>20</tpages></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 1966-03, Vol.36 (3), p.483-502 |
| issn | 0027-8874 1460-2105 |
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| source | MEDLINE; Oxford Journals A-Z Collection |
| subjects | 9,10-Dimethyl-1,2-benzanthracene - administration & dosage 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Carcinogens - administration & dosage Carcinogens - toxicity Female Fibroadenoma - chemically induced Fibroadenoma - pathology Fibrocystic Breast Disease - chemically induced Fibrocystic Breast Disease - pathology Male Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - pathology Methylcholanthrene - administration & dosage Methylcholanthrene - toxicity Rats Rats, Sprague-Dawley Rats, Wistar Stomach Time Factors |
| title | Carcinogenic Effects of Intragastric 3-Methylcholanthrene and 7,12-Dimethylbenz[a]anthracene in Wistar and Sprague-Dawley Rats |
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